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Haploidentical Transplantation pp 111–125Cite as

Graft Source: Marrow or Peripheral Blood with Posttransplant Cyclophosphamide—What Matters?

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Abstract

The choice of bone marrow (BM) or G-CSF-mobilized peripheral blood (PB) as the source of CD34+ cells for transplantation from HLA-haploidentical, related donors is controversial. Short of a randomized clinical trial comparing these two graft sources (which is highly unlikely), it has been necessary to compare multicenter or single-center phase II data retrospectively using either of these two graft sources in the setting of ablative or non-myeloablative conditioning or by comparing registry data. This chapter will review the data and will discuss whether BM or PB as the source of graft for haploidentical transplantation using PTCy makes any difference in the transplant outcomes of engraftment/hematopoietic recovery, acute and chronic GvHD, NRM, relapse, or survival.

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Authors and Affiliations

  1. Massachusetts General Hospital Cancer Center, Boston, MA, USA

    Paul V. O’Donnell M.D., Ph.D., F.A.C.P.

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  1. Paul V. O’Donnell M.D., Ph.D., F.A.C.P.
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Correspondence to Paul V. O’Donnell M.D., Ph.D., F.A.C.P. .

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Editors and Affiliations

  1. Department of Stem Cell Transplantation, MD Anderson Cancer Center, Houston, Texas, USA

    Stefan O. Ciurea

  2. Department of General Pediatrics and Hematology/Oncology, University Children’s Hospital, Tübingen, Baden-Württemberg, Germany

    Rupert Handgretinger

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O’Donnell, P.V. (2018). Graft Source: Marrow or Peripheral Blood with Posttransplant Cyclophosphamide—What Matters?. In: Ciurea, S., Handgretinger, R. (eds) Haploidentical Transplantation. Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-54310-9_8

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  • DOI: https://doi.org/10.1007/978-3-319-54310-9_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-54309-3

  • Online ISBN: 978-3-319-54310-9

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