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Haploidentical Transplants for Myeloproliferative Neoplasms

  • Monzr M. Al Malki
  • Stefan O. Ciurea
  • Richard E. Champlin
Chapter
Part of the Advances and Controversies in Hematopoietic Transplantation and Cell Therapy book series (ACHTCT)

Abstract

Allogeneic hematopoietic cell transplantation remains the only curative therapy available for patients with myeloproliferative neoplasms and is mostly performed for primary myelofibrosis or secondary myelofibrosis with high dynamic international scoring system-plus score, advanced (or refractory) chronic myelogenous leukemia, and chronic myelomonocytic leukemia, traditionally with HLA-matched donors. The outcomes for chronic myelogenous leukemia with HLA-matched unrelated donors may be similar with HLA-matched sibling donor transplants; outcomes for other MPNs may not be the same. In the setting of HLA-matched unrelated donors, the results with busulfan-based conditioning for patients with myelofibrosis are encouraging. Multiple single institution and registry studies have shown safety of haploidentical transplants with comparable outcomes as HLA-matched transplants. All studies so far have shown lower incidence of acute and chronic GvHD with comparable treatment-related mortality to HLA-matched unrelated transplants. In this chapter, we will review the strengths and weaknesses of different platforms using HLA-haploidentical-matched donors for chronic myelogenous leukemia and myelofibrosis.

Keywords

Haploidentical transplants Myelofibrosis (MPN) Myeloproliferative neoplasms GvHD Relapse Conditioning CML 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Monzr M. Al Malki
    • 1
  • Stefan O. Ciurea
    • 2
  • Richard E. Champlin
    • 2
  1. 1.City of Hope National Medical CenterDuarteUSA
  2. 2.Department of Stem cell Transplantation and Cellular TherapyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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