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Macrophages pp 365–376Cite as

Macrophages and RhoA Pathway in Transplanted Organs

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 62))

Abstract

RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also pivotal for proper functioning of immune cells including macrophages. By controlling actin cytoskeleton organization, RhoA pathway modulates macrophage’s polarity and basic functions: phagocytosis, migration, and extracellular matrix degradation. Numerous studies indicate that macrophages are very important effectors contributing to acute and chronic rejection of transplanted organs. In this review we discuss the role of RhoA pathway in governance of macrophage’s functions in terms of transplanted organs.

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Author information

Authors and Affiliations

  1. The Houston Methodist Research Institute, Houston, TX, USA

    Yianzhu Liu, Xian C. Li, Rafik M. Ghobrial & Malgorzata Kloc

  2. Department of Surgery, The Houston Methodist Hospital, 6550 Fannin St, Houston, TX, 77030, USA

    Yianzhu Liu, Xian C. Li, Rafik M. Ghobrial & Malgorzata Kloc

  3. Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China

    Yianzhu Liu

  4. CNRS UMR 6290, Institute of Genetics and Development of Rennes, Cell Cycle Group, IFR 140 GFAS, Rennes, France

    Jacek Z. Kubiak

  5. Faculty of Medicine, University of Rennes 1, 35043, Rennes, France

    Jacek Z. Kubiak

  6. Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology (WIHE), Warsaw, Poland

    Jacek Z. Kubiak

  7. Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston, TX, USA

    Rafik M. Ghobrial

Authors
  1. Yianzhu Liu
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  2. Jacek Z. Kubiak
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  3. Xian C. Li
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  4. Rafik M. Ghobrial
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  5. Malgorzata Kloc
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Corresponding author

Correspondence to Malgorzata Kloc .

Editor information

Editors and Affiliations

  1. Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA

    Malgorzata Kloc

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Liu, Y., Kubiak, J.Z., Li, X.C., Ghobrial, R.M., Kloc, M. (2017). Macrophages and RhoA Pathway in Transplanted Organs. In: Kloc, M. (eds) Macrophages. Results and Problems in Cell Differentiation, vol 62. Springer, Cham. https://doi.org/10.1007/978-3-319-54090-0_15

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