Abstract
Autophagy, an evolutionarily conserved process, is crucial for survival, development, and homeostasis. It serves to remove damaged cellular components, such as mitochondria and long-lived proteins. Increased understanding of autophagy within liver cancer indicates that, in addition to the role of tumor promotion, autophagy also could suppress cancer progression by various cellular machineries. This chapter summarizes recent advances about dual roles of autophagy in tumor promotion and suppression, and discusses the intrinsic mechanism and application about autophagy inducers and inhibitors in clinical treatments with experimental results developed in vivo and in vitro systems.
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Abbreviations
- 3-MA:
-
3-methyladenine
- ATD:
-
Alpha1-antitrypsin deficiency
- ATG:
-
Autophagy-related gene
- CBZ:
-
Carbamazepine
- CQ:
-
Chloroquine
- HBV:
-
Hepatitis B virus
- HCC:
-
Hepatocellular carcinoma
- HCQ:
-
Hydroxychloroquine
- HCV:
-
Hepatitis C virus
- ICC:
-
Intrahepatic cholangiocarcinoma
- MDBs:
-
Mallory-denk bodies
- NAFLD:
-
Nonalcoholic fatty liver disease
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Tian, MX., Peng, YF., Wang, H., Fan, J., Shi, YH. (2017). Cell Death and Autophagy in Liver Tumorigenesis and Liver Cancer. In: Ding, WX., Yin, XM. (eds) Cellular Injury in Liver Diseases. Cell Death in Biology and Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-53774-0_11
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