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Genetic Influences on the Periodontal Microbial-Host Crosstalk

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Pathogenesis of Periodontal Diseases

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Abstract

Previous chapters of this book have discussed the importance of subgingival microbial colonization and of the inflammatory-immune response as triggers of periodontal tissue breakdown. In fact, it appears clear that periodontal health or pathology is the result of the interaction between the human host and its invading microbes. Or perhaps we should not define them as ‘invading’, since it is well known that microbes not only coexist with their human host, but also provide multiple vital functions for the survival of the host itself [1]. Compelling evidence has now emerged to suggest that host genetic variants have a fundamental effect in regulating the host’s relationships with the microbial ‘guests’ and a better knowledge of how these effects are implemented is crucial in the understanding of disease processes. This chapter will review the evidence on the effect of host genetic factors on periodontal microbial colonization and will provide examples of how this could have an impact in clinical practice.

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Author information

Authors and Affiliations

  1. Centre for Oral Clinical Research, Institute of Dentistry, Queen Mary University of London, Turner Street, London, E12AD, UK

    Luigi Nibali

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  1. Luigi Nibali
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Correspondence to Luigi Nibali .

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Editors and Affiliations

  1. Department of Dental Medicine, Karolinska Institute Department of Dental Medicine, Huddinge, Sweden

    Nagihan Bostanci

  2. Department of Dental Medicine, Karolinska Institute Department of Dental Medicine, Huddinge, Sweden

    Georgios N. Belibasakis

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Nibali, L. (2018). Genetic Influences on the Periodontal Microbial-Host Crosstalk. In: Bostanci, N., Belibasakis, G. (eds) Pathogenesis of Periodontal Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-53737-5_7

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  • DOI: https://doi.org/10.1007/978-3-319-53737-5_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-53735-1

  • Online ISBN: 978-3-319-53737-5

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