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Mechanisms of Molecular Carcinogenesis – Volume 2 pp 359–374Cite as

Modelling Molecular Mechanisms of Cancer Pathogenesis: Virtual Patients, Real Opportunities

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Abstract

A combination of decades of cancer research and trillions of dollars has helped to exponentially increase our understanding of the molecular processes involved in cancer pathogenesis [1, 2] and to develop new cancer drugs. However, despite progress in diagnosing and treating cancer, these diseases remain one of the leading causes of morbidity and mortality worldwide, responsible for millions of deaths each year [3]. Moreover, we are still faced, on average, with low drug response rates, very serious treatment side effects and questionable survival benefits. In Europe alone, cancer kills around 4000 people every day [4] and costs billions per year [5]. Worldwide, the number of new cancer cases is increasing every year [4], at least partly due to rapidly ageing populations [6], with the number of new cancer cases projected to reach 25 million per year by 2030, and cure rates for many common forms of cancer stagnating [4]. Due to the high number of nonresponders to existing drugs and spiralling costs of new cancer drugs—costs have almost doubled in the last decade, resulting in a dramatic decrease in the number of new drugs—an individualised approach to the diagnosis and treatment of cancer patients is desperately required.

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Acknowledgements

The authors would like to thank their colleagues at Alacris Theranostics GmbH and the Dahlem Centre for Genome Research and Medical Systems Biology (DCGMS), for fruitful discussions and constructive criticism.

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Authors and Affiliations

  1. Max Planck Institute for Molecular Genetics (MPIMG), Ihnestrasse 63-73, 14195, Berlin, Germany

    Hans Lehrach, Thomas Kessler & Christoph Wierling

  2. Dahlem Centre for Genome Research and Medical Systems Biology (DCGMS), Berlin, Germany

    Hans Lehrach

  3. Alacris Theranostics GmbH, Berlin, Germany

    Hans Lehrach, Thomas Kessler, Lesley Ogilvie, Moritz Schütte & Christoph Wierling

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Correspondence to Hans Lehrach .

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  1. Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany

    Johannes Haybaeck

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Lehrach, H., Kessler, T., Ogilvie, L., Schütte, M., Wierling, C. (2017). Modelling Molecular Mechanisms of Cancer Pathogenesis: Virtual Patients, Real Opportunities. In: Haybaeck, J. (eds) Mechanisms of Molecular Carcinogenesis – Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-319-53661-3_16

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