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Congenital Zika Syndrome: Clinical Aspects

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Zika in Focus

Abstract

Microcephaly is a condition in which a baby has a smaller head compared to other babies of the same sex and age. An infant is considered to have microcephaly when the head circumference (also known as occipitofrontal circumference) is less than a specific cutoff value compared to head circumference reference standards for boys or girls of equivalent gestational or postnatal age. Head circumference reflects intracranial volume, and it is an important measurement to monitor a child’s brain growth.

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References

  1. World Health Organization. Screening, assessment and management of neonates and infants with complications associated with Zika virus exposure in utero. Updated 30 Aug 2016, WHO reference number: WHO/ZIKV/MOC/16.3 Rev.3.

    Google Scholar 

  2. World Health Organization. WHO statement on the first meeting of the International Health Regulations (2005) (IHR 2005) Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations. http://www.who.int/mediacentre/news/statements/2016/1st-emergency-committee-zika/en/. Accessed 01 Feb 2016.

  3. Costello A, Dua T, Duran P, et al. Defining the syndrome associated with congenital Zika virus infection. Bull World Health Organ. 2016;94(6):406–406A.

    Article  PubMed  PubMed Central  Google Scholar 

  4. van der Linden V, Pessoa A, Dobyns W, et al. Description of 13 infants born during October 2015–January 2016 with congenital Zika virus infection without microcephaly at birth—Brazil. http://www.cdc.gov/mmwr/volumes/65/wr/mm6547e2.htm?s_cid=mm6547e2_e. Accessed 22 Nov 2016.

  5. Moore CA, Staples EJ, Dobyns WB, et al. Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians. JAMA Pediatr. Published online 3 Nov 2016.

    Google Scholar 

  6. Russell LJ, Weaver DD, Bull MJ, Weinbaum M. In utero brain destruction resulting in collapse of the fetal skull, microcephaly, scalp rugae, and neurologic impairment: the fetal brain disruption sequence. Am J Med Genet. 1984;17(2):50.

    Article  Google Scholar 

  7. van der Linden V, Filho ER, Lins OG, van der Linden A, Aragão Mde F, Brainer-Lima AM, et al. Congenital Zika syndrome with arthrogryposis: retrospective case series study. BMJ. 2016;354:i3899.

    Google Scholar 

  8. Leal MC, Muniz LF, Ferreira TS, et al. Hearing loss in infants with microcephaly and evidence of congenital Zika virus infection—Brazil, November 2015–May 2016. MMWR Morb Mortal Wkly Rep. 2016.

    Google Scholar 

  9. Ventura CV, Maia M, Ventura BV, et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol. 2016;79:1.

    PubMed  Google Scholar 

  10. de Fátima Vasco Aragão M, van der Linden V, Brainer-Lima AM, Coeli RR, Rocha MA, Sobral da Silva P, et al. Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. BMJ. 2016;353:i1901.

    Google Scholar 

  11. Alves LV, Cruz DDCS, van der Linden A, et al. Epileptic seizures in children with congenital Zika virus syndrome. Rev Bras Saúde Matern Infant Recife. 2016;16(1):S27–31.

    Article  Google Scholar 

  12. Bamshad M, Heest AE, Pleasure D. Arthrogryposis: a review and update. J Bone Joint Surg Am. 2009;91(Suppl 4):40–6.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kalampokas E, Kalampokas T, Sofoudis C, Deligeoroglou E, Botsis D. Diagnosing arthrogryposis multiplex congenita: a review. ISRN Obstet Gynecol. 2012;2012:264918.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, et al. Possible association between Zika virus infection and microcephaly—Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65(3):59–62.

    Article  PubMed  Google Scholar 

  15. Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo de Filippis AM. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol. 2016;47(1):6–7.

    Article  CAS  PubMed  Google Scholar 

  16. de Fátima Vasco Aragão M, Brainer-Lima AM, Holanda AC, van der Linden V, Aragão LV, Silva Júnior MLM, Sarteschi C, Petribu NCL, van der Linden A, Valença MM. (IN PRESS) Spectrum of spinal cord, spinal roots and brain MRI abnormalities in congenital Zika syndrome with and without arthrogryposis. AJNR. 2017.

    Google Scholar 

  17. Li C, Xu D, Ye Q, et al. Zika virus disrupts neural progenitor development and leads to microcephaly in mice. Cell Stem Cell. 2016;19:1–7. doi:10.1016/j.stem.2016.04.017.

    Article  CAS  Google Scholar 

  18. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, et al. Zika virus associated with microcephaly. N Engl J Med. 2016. doi:10.1056/NEJMoa1600651.

    PubMed  Google Scholar 

  19. Garcez PP, Loiola EC, Madeiro da Costa R, et al. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016;352:816.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Hospital Barão de Lucena, Recife, PE, Brazil

    Vanessa van der Linden

  2. Universidade Federal de Pernambuco, Recife, PE, Brazil

    Epitacio Leite Rolim Filho

  3. IMIP—Instituto Materno Infantil Prof. Fernando Figueira, Recife, PE, Brazil

    Ana van der Linden

Authors
  1. Vanessa van der Linden
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  2. Epitacio Leite Rolim Filho
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  3. Ana van der Linden
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Corresponding author

Correspondence to Vanessa van der Linden .

Editor information

Editors and Affiliations

  1. Centro Diagnóstico Multimagem, Mauricio de Nassau University, Recife, Pernambuco, Brazil

    Maria de Fátima Viana Vasco Aragão

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van der Linden, V., Filho, E.L.R., van der Linden, A. (2017). Congenital Zika Syndrome: Clinical Aspects. In: Vasco Aragão, M. (eds) Zika in Focus. Springer, Cham. https://doi.org/10.1007/978-3-319-53643-9_3

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  • DOI: https://doi.org/10.1007/978-3-319-53643-9_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-53642-2

  • Online ISBN: 978-3-319-53643-9

  • eBook Packages: MedicineMedicine (R0)

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