Skip to main content
SpringerLink
Log in
Book cover

Cord Blood Transplantations pp 141–150Cite as

Cord Blood Transplants for Myeloid Malignancies in Children

  • Chapter
  • First Online:

  • 384 Accesses

Abstract

Pediatric myeloid malignancies include diagnoses such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), chronic myelogenous leukemia (CML), and juvenile myelomonocytic leukemia (JMML). While rare, they have been associated with poor outcomes and often require hematopoietic cell transplantation (HCT) for cure. In the effort to expand the donor pool and offer HCT to more patients, cord blood is being used more frequently in recent history. The role of cord blood HCT for each of these pediatric myeloid malignancies is reviewed as well as the advantages and disadvantages relative to other donor sources.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Anasetti C (2015) Use of alternative donors for allogeneic stem cell transplantation. Hematology Am Soc Hematol Educ Program 2015:220–224

    PubMed  Google Scholar 

  • Appelbaum FR, Thomas ED (2009) Thomas’ hematopoietic cell transplantation stem cell transplantation. In: Frederick RA (ed) 4th edn. Wiley-Blackwell, Chichester/Hoboken, pp xxx, 1718 p., 32 p. of plates ill. (some col.) 29 cm. + 1 CD-ROM

    Google Scholar 

  • Ballen KK (2015) Is there a best graft source of transplantation in acute myeloid leukemia? Best Pract Res Clin Haematol 28:147–154

    Article  PubMed  Google Scholar 

  • Ballen KK, Lazarus H (2016) Cord blood transplant for acute myeloid leukaemia. Br J Haematol 173:25–36

    Article  PubMed  Google Scholar 

  • Barker JN, Byam CE, Kernan NA et al (2010) Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities. Biol Blood Marrow Transplant 16:1541–1548

    Article  PubMed  PubMed Central  Google Scholar 

  • Brunstein CG, McKenna DH, DeFor TE et al (2013) Complement fragment 3a priming of umbilical cord blood progenitors: safety profile. Biol Blood Marrow Transplant 19:1474–1479

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brunstein CG, Miller JS, McKenna DH et al (2016) Umbilical cord blood-derived T regulatory cells to prevent GvHD: kinetics, toxicity profile, and clinical effect. Blood 127:1044–1051

    Google Scholar 

  • Cairo MS, Tarek N, Lee DA et al (2016) Cellular engineering and therapy in combination with cord blood allografting in pediatric recipients. Bone Marrow Transplant 51:27–33

    Article  CAS  PubMed  Google Scholar 

  • Carrancio S, Romo C, Ramos T et al (2013) Effects of MSC coadministration and route of delivery on cord blood hematopoietic stem cell engraftment. Cell Transplant 22:1171–1183

    Article  CAS  PubMed  Google Scholar 

  • Cutler C, Kim HT, Sun L et al (2011) Donor-specific anti-HLA antibodies predict outcome in double umbilical cord blood transplantation. Blood 118:6691–6697

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cutler C, Multani P, Robbins D et al (2013) Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood 122:3074–3081

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Delaney C, Heimfeld S, Brashem-Stein C et al (2010) Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 16:232–236

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eapen M, Rubinstein P, Zhang MJ et al (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 369:1947–1954

    Article  PubMed  Google Scholar 

  • Farag SS, Srivastava S, Messina-Graham S et al (2013) In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies. Stem Cells Dev 22:1007–1015

    Article  CAS  PubMed  Google Scholar 

  • Hanley PJ, Cruz CR, Savoldo B et al (2009) Functionally active virus-specific T-cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood 114:1958–1967

    Google Scholar 

  • Horwitz ME, Chao NJ, Rizzieri DA et al (2014) Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J Clin Invest 124:3121–3128

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kurtzberg J, Prasad VK, Carter SL et al (2008) Results of the cord blood transplantation study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood 112:4318–4327

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de Lima M, McNiece I, Robinson SN et al (2012) Cord-blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med 367:2305–2315

    Article  PubMed  PubMed Central  Google Scholar 

  • Locatelli F, Crotta A, Ruggeri A et al (2013) Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study. Blood 122:2135–2141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Locatelli F, Masetti R, Rondelli R et al (2015) Outcome of children with high-risk acute myeloid leukemia given autologous or allogeneic hematopoietic cell transplantation in the aieop AML-2002/01 study. Bone Marrow Transplant 50:181–188

    Article  CAS  PubMed  Google Scholar 

  • Madureira AB, Eapen M, Locatelli F et al (2011) Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation. Leukemia 25:449–454

    Article  CAS  PubMed  Google Scholar 

  • Michel G, Rocha V, Chevret S et al (2003) Unrelated cord blood transplantation for childhood acute myeloid leukemia: a Eurocord group analysis. Blood 102:4290–4297

    Article  CAS  PubMed  Google Scholar 

  • Micklethwaite KP, Savoldo B, Hanley PJ et al (2010) Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation. Blood 115:2695–2703

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nagamura-Inoue T, Kai S, Azuma H et al (2008) Unrelated cord blood transplantation in CML: Japan cord blood Bank network analysis. Bone Marrow Transplant 42:241–251

    Article  CAS  PubMed  Google Scholar 

  • Parikh SH, Mendizabal A, Martin PL et al (2009) Unrelated donor umbilical cord blood transplantation in pediatric myelodysplastic syndrome: a single-center experience. Biol Blood Marrow Transplant 15:948–955

    Article  PubMed  Google Scholar 

  • Popat U, Mehta RS, Rezvani K et al (2015) Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation. Blood 125:2885–2892

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Robinson SN, Simmons PJ, Thomas MW et al (2012) Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγ(null) mice. Exp Hematol 40:445–456

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rocha V, Kabbara N, Ionescu I et al (2009) Pediatric related and unrelated cord blood transplantation for malignant diseases. Bone Marrow Transplant 44:653–659

    Article  CAS  PubMed  Google Scholar 

  • Simula MP, Marktel S, Fozza C et al (2007) Response to donor lymphocyte infusions for chronic myeloid leukemia is dose-dependent: the importance of escalating the cell dose to maximize therapeutic efficacy. Leukemia 21:943–948

    CAS  PubMed  Google Scholar 

  • Smith AR, Christiansen EC, Wagner JE et al (2013) Early hematopoietic stem cell transplant is associated with favorable outcomes in children with MDS. Pediatr Blood Cancer 60:705–710

    Article  PubMed  Google Scholar 

  • Thompson PA, Rezvani K, Hosing CM et al (2015) Umbilical cord blood graft engineering: challenges and opportunities. Bone Marrow Transplant 50(Suppl 2):S55–S62

    Article  PubMed  Google Scholar 

  • Vardiman JW, Thiele J, Arber DA et al (2009) The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 114:937–951

    Article  CAS  PubMed  Google Scholar 

  • Venepalli N, Rezvani K, Mielke S et al (2010) Role of Allo-SCT for CML in 2010. Bone Marrow Transplant 45:1579–1586

    Article  CAS  PubMed  Google Scholar 

  • Wagner JE, Eapen M, Carter S et al (2014) One-unit versus two-unit cord-blood transplantation for hematologic cancers. N Engl J Med 371:1685–1694

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wagner JE, Brunstein CG, Boitano AE et al (2016) Phase I/II trial of stemregenin-1 expanded umbilical cord blood hematopoietic stem cells supports testing as a stand-alone graft. Cell Stem Cell 18:144–155

    Article  CAS  PubMed  Google Scholar 

  • Ward E, DeSantis C, Robbins A et al (2014) Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 64:83–103

    Article  PubMed  Google Scholar 

  • Zheng C, Tang B, Yao W et al (2013) Comparison of unrelated cord blood transplantation and HLA-matched sibling hematopoietic stem cell transplantation for patients with chronic myeloid leukemia in advanced stage. Biol Blood Marrow Transplant 19:1708–1712

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA

    Andrew C. Dietz MD, MSCR

  2. University of Colorado at Denver, Denver, CO, USA

    Michael R. Verneris MD

Authors
  1. Andrew C. Dietz MD, MSCR
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael R. Verneris MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrew C. Dietz MD, MSCR .

Editor information

Editors and Affiliations

  1. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Mitchell Horwitz

  2. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Nelson Chao

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Dietz, A.C., Verneris, M.R. (2017). Cord Blood Transplants for Myeloid Malignancies in Children. In: Horwitz, M., Chao, N. (eds) Cord Blood Transplantations. Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-53628-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-53628-6_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-53627-9

  • Online ISBN: 978-3-319-53628-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation