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Cord Blood Transplants Versus Other Sources of Allografts: Comparison of Data in Adult Setting

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Cord Blood Transplantations

Abstract

In the absence of a human leukocyte antigen (HLA)-matched related donor, umbilical cord blood (UCB) provides an excellent alternative graft source for hematopoietic cell transplantation. It is, however, associated with delayed neutrophil engraftment leading to a higher risk of graft failure and non-relapse mortality. On the other hand, despite HLA mismatch, the risk of acute or chronic graft-versus-host disease (GvHD) is significantly lower after UCB transplantation as compared with any other graft source with similar degree of mismatch. Moreover, the risk of relapse, disease-free survival, and overall survival after UCB transplantation is comparable to that of other graft types. Outcomes of UCB transplantation as compared with partially HLA-matched related donor (haploidentical) transplantation are currently being evaluated in a randomized clinical trial.

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Authors and Affiliations

  1. Division of Hematology, Oncology and Transplantation, University of Minnesota Medical School, 420 Delaware St SE, MMC 480, Minneapolis, MN, 55455, USA

    Rohtesh S. Mehta & Claudio G. Brunstein

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  1. Rohtesh S. Mehta
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  2. Claudio G. Brunstein
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Correspondence to Rohtesh S. Mehta .

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  1. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Mitchell Horwitz

  2. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Nelson Chao

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Mehta, R.S., Brunstein, C.G. (2017). Cord Blood Transplants Versus Other Sources of Allografts: Comparison of Data in Adult Setting. In: Horwitz, M., Chao, N. (eds) Cord Blood Transplantations. Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-53628-6_14

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  • DOI: https://doi.org/10.1007/978-3-319-53628-6_14

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