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Cord Blood Transplantations pp 217–229Cite as

Cord Blood Therapies for Genetic and Acquired Brain Injuries

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Abstract

As the practice of umbilical cord blood transplantation (CBT) has evolved, outcomes in many indications are now comparable to hematopoietic cell transplantation (HCT) using other unrelated donor sources. The ability to quickly procure a suitable HLA-matched cord blood (CB) unit with a sufficient cell dose for pediatric patients has made CB a reliable, and even preferred, cell source for children with certain rapidly progressive diseases. In particular, CBT can favorably alter the clinical course of disease and increase survival in infants and children with neurologically devastating inherited metabolic disorders (IMDs). Based in part on observations of neurologic benefit in the IMDs and due to a dearth of available therapies for other neurologic conditions, interest has grown in developing cellular therapies for acquired brain injuries. Ease of access, a favorable safety profile, and mounting preclinical evidence of potential efficacy make CB an attractive cell source for such therapies. These concepts are reviewed and discussed in this chapter.

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Authors and Affiliations

  1. Pediatric Blood and Marrow Transplant Program and Robertson Clinical and Translational Cell Therapy Program, Duke University Medical Center, Durham, NC, USA

    Jessica M. Sun MD & Joanne Kurtzberg MD

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  1. Jessica M. Sun MD
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  2. Joanne Kurtzberg MD
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Correspondence to Jessica M. Sun MD .

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  1. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Mitchell Horwitz

  2. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Nelson Chao

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Sun, J.M., Kurtzberg, J. (2017). Cord Blood Therapies for Genetic and Acquired Brain Injuries. In: Horwitz, M., Chao, N. (eds) Cord Blood Transplantations. Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-53628-6_13

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  • DOI: https://doi.org/10.1007/978-3-319-53628-6_13

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