Skip to main content
SpringerLink
Log in

Historical Perspective and Current Trends of Umbilical Cord Blood Transplantation

  • Chapter
  • First Online:
Cord Blood Transplantations

  • 398 Accesses

Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment for patients with hematological diseases. HLA-matched donors could be either siblings or unrelated donors found in international registries for unrelated donors. Patients in need of allo-HCT may also benefit of a HLA-mismatched allo-HCT either from a haploidentical donor or from umbilical cord blood (UCB). Much has been learned about UCBT since the first human cord blood transplant (UCBT) was performed back in 1988. Cord blood banks have been established worldwide for the collection, cryopreservation, and distribution of UCB for allo-HCT. Today, a global network of cord blood banks and transplant centers has been established with a large common inventory of more than 650,000 UCB units available, allowing for more than 40,000 UCBT worldwide in children and adults with severe hematological diseases. Several studies have been published on UCBT, assessing risk factors such as cell dose and HLA mismatch. Outcomes of several retrospective comparative studies showed similar results using other graft sources both in pediatric and adult settings. New strategies are ongoing to facilitate engraftment and reduce transplant-related mortality.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Auerbach AD, Liu Q, Ghosh R, Pollack MS, Douglas GW, Broxmeyer HE (1990) Prenatal identification of potential donors for umbilical cord blood transplantation for Fanconi anemia. Transfusion 30(8):682–687

    Article  CAS  PubMed  Google Scholar 

  • Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, McGlave PB, Miller JS et al (2005) Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 105(3):1343–1347

    Article  CAS  PubMed  Google Scholar 

  • Barker JN, Scaradavou A, Stevens CE (2010) Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood 115(9):1843–1849

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Boitano AE, Wang J, Romeo R et al (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345–1348

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D et al (1989) Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A 86(10):3828–3832

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Broxmeyer HE, Hangoc G, Cooper S, Ribeiro RC, Graves V, Yoder M et al (1992) Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults. Proc Natl Acad Sci U S A 89(9):4109–4113

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brunstein CG, Barker JN, Weisdorf DJ, DeFor TE, Miller JS, Blazar BR et al (2007) Umbilical cord blood transplantation after non-myeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood 110(8):3064–3070

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brunstein CG, Gutman JA, Weisdorf DJ et al (2010) Allogeneic hematopoietic cell transplantation for hematologi malignancy: relative risks and benefits of double umbilical cord blood. Blood 116(22):4693–4699

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brunstein CG, Noreen H, DeFor TE, Maurer D, Miller JS, Wagner JE (2011) Anti-HLA antibodies in double umbilical cord blood transplantation. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl 17(11):1704–1708

    Article  CAS  Google Scholar 

  • Brunstein CG, Eapen M, Ahn KW et al (2012) Reduced intensity conditioning in acute leukemia: the effect of source of unrelated donor stem cells on outcome. Blood 119(23):5591–5598

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brunstein CG1, McKenna DH, DeFor TE, Sumstad D, Paul P, Weisdorf DJ, et al (2013)Complement fragment 3a priming of umbilical cord blood progenitors: safety profile. Biol Blood Marrow Transplant. 2013;19(10):1474–1479

    Google Scholar 

  • Cairo MS, Wagner JE (1997) Placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation. Blood 90(12):4665–4678

    CAS  PubMed  Google Scholar 

  • Cuttler C, Kim HT, Sun L, Sese D, Glotzbecker B, Armand P et al (2011) Donor-specific anti-HLA antibodies predict outcome in double umbilical cord blood transplantation. Blood 118(25):6691–6697

    Article  Google Scholar 

  • Cuttler C, Multani P, Robbins D et al (2013) Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood 122(17):3074–3081

    Article  Google Scholar 

  • Dahi PB, Barone J, Devlin SM, Byam C, Lubin M, Ponce DM, Giralt S, Kernan NA, Scaradavou A, Hsu SH, Barker JN (2014) Sustained donor engraftment in recipients of double-unit cord blood transplantation is possible despite donor-specific human leukocyte antigen antibodies. Biol Blood Marrow Transplant 20(5):735–739

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de Lima M, McMannis J, Gee A et al (2008) Transplantation of ex vivo expanded cord blood cells using the copper chelator tetra ethyelenepentamine: a phase I/II clinical trial. Bone Marrow Transplant 41(9):771–778

    Google Scholar 

  • de Lima M, McNiece I, Robinson SN, Munsell M, Eapen M, Horowitz M, Alousi A, Saliba R, McMannis JD, Kaur I, Kebriaei P, Parmar S, Popat U, Hosing C, Champlin R, Bollard C, Molldrem JJ, Jones RB, Nieto Y, Andersson BS, Shah N, Oran B, Cooper LJ, Worth L, Qazilbash MH, Korbling M, Rondon G, Ciurea S, Bosque D, Maewal I, Simmons PJ, Shpall EJ (2012) Cord-blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med 367(24):2305–2315

    Article  PubMed  PubMed Central  Google Scholar 

  • Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID (2010) Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 16(2):232–236

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A et al (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 369(9577):1947–1954

    Article  PubMed  Google Scholar 

  • Eapen M, Rocha V, Sanz G, Scaradavou A, Zhang MJ, Arcese W et al (2010) Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis. Lancet Oncol 11(7):653–660

    Article  PubMed  PubMed Central  Google Scholar 

  • Eapen M, Klein JP, Sanz GF, Spellman S, Ruggeri A, Anasetti C et al (2011) Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis. Lancet Oncol 12(13):1214–1221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eapen M, Klein JP, Ruggeri A, Spellman S, Lee SJ, Anasetti C, Arcese W, Barker JN, Baxter-Lowe LA, Brown M, Fernandez-Vina MA, Freeman J, He W, Iori AP, Horowitz MM, Locatelli F, Marino S, Maiers M, Michel G, Sanz GF, Gluckman E, Rocha V (2014) Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy. Blood 123(1):133–140

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Farag SS, Srivastava S, Messina-Graham S, Schwartz J, Robertson MJ, Abonour R, Cornetta K, Wood L, Secrest A, Strother RM, Jones DR, Broxmeyer HE (2013) In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies. Stem Cells Dev 22(7):1007–1015

    Article  CAS  PubMed  Google Scholar 

  • Gluckman E, Devergie A, Dutreix J (1983) Radiosensitivity in Fanconi anaemia: application to the conditioning regimen for bone marrow transplantation. Br J Haematol 54(3):431–440

    Article  CAS  PubMed  Google Scholar 

  • Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A et al (1989) Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 321(17):1174–1178

    Article  CAS  PubMed  Google Scholar 

  • Gluckman E, Rocha V, Boyer-Chammard A, Locatelli F, Arcese W, Pasquini R et al (1997) Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 337(6):373–381

    Article  CAS  PubMed  Google Scholar 

  • Gluckman E, Rocha V, Arcese W, Michel G, Sanz G, Chan KW et al (2004) Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol 32(4):397–407

    Article  CAS  PubMed  Google Scholar 

  • Horwitz ME, Chao NJ, Rizzieri DA, Long GD, Sullivan KM, Gasparetto C, Chute JP, Morris A, McDonald C, Waters-Pick B, Stiff P, Wease S, Peled A, Snyder D, Cohen EG, Shoham H, Landau E, Friend E, Peleg I, Aschengrau D, Yackoubov D, Kurtzberg J, Peled T (2014) Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J Clin Invest 124(7):3121–3128

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jaroscak J, Goltry K, Smith A et al (2003) Augmentation of umbilical cord blood (UCB) transplantation with ex-vivo expanded UCB cells: results of a phase 1 trial using the AastromReplicel System. Blood 101(12):5061–5067

    Article  CAS  PubMed  Google Scholar 

  • Komanduri KV, St John LS, de Lima M, McMannis J, Rosinski S, McNiece I et al (2007) Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood 110(13):4543–4551

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kurtzberg J, Laughlin M, Graham ML, Smith C, Olson JF, Halperin EC et al (1996) Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med 335(3):157–166

    Article  CAS  PubMed  Google Scholar 

  • Kurtzberg J, Prasad VK, Carter SL, Wagner JE, Baxter-Lowe LA, Wall D, Kapoor N, Guinan EC, Feig SA, Wagner EL, Kernan NA, COBLT Steering Committee (2008) Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood 112(10):4318–4327

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Laughlin MJ, Barker J, Bambach B, Koc ON, Rizzieri DA, Wagner JE et al (2001) Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 344(24):1815–1822

    Article  CAS  PubMed  Google Scholar 

  • Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang MJ, Champlin RE et al (2004) Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 351(22):2265–2275

    Article  CAS  PubMed  Google Scholar 

  • Locatelli F, Rocha V, Chastang C, Arcese W, Michel G, Abecasis M et al (1999) Factors associated with outcome after cord blood transplantation in children with acute leukemia. Eurocord-Cord Blood Transplant Group. Blood 93(11):3662–3671

    CAS  PubMed  Google Scholar 

  • MacMillan ML, Weisdorf DJ, Brunstein CG, Cao Q, DeFor TE, Verneris MR et al (2009) Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors. Blood 113(11):2410–2415

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Malard F, Milpied N, Blaise D et al (2015) Effect of graft source on unrelated donor hematopoietic stem cell transplantation in adults with acute myeloid leukemia after reduced–intensity or non myeloablative conditioning: a study from the Société Francaise de Greffe de Moelle et de thérapie cellulaire. Biol Blood Marrow Transplant 21(6):1059–1067

    Google Scholar 

  • Michel G, Galambrun C, Sirvent A, Pochon C, Bruno B, Jubert C, Loundou A, Yakoub-Agha I, Milpied N, Lutz P, Marie-Cardine A, Gandemer V, Blaise D, Michallet M, Rialland F, Renard C, Oudin C, Esmiol S, Seux M, Baumstarck K, Mohty M, Rocha V, Dalle JH (2016) Single versus double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome. Blood 127:3450–3457. Pii: blood-2016-01-694349. [Epub ahead of print]

    Google Scholar 

  • Robinson SN, Thomas MW, Simmons PJ et al (2014) Fucolysation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment. Cytotherapy 16(1):84–89

    Google Scholar 

  • Rocha V, Wagner JE Jr, Sobocinski KA, Klein JP, Zhang MJ, Horowitz MM et al (2000) Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. N Engl J Med 342(25):1846–1854

    Google Scholar 

  • Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A et al (2004) Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 351(22):2276–2285

    Article  CAS  PubMed  Google Scholar 

  • Rubinstein P, Rosenfield RE, Adamson JW, Stevens CE (1993) Stored placental blood for unrelated bone marrow reconstitution. Blood 81(7):1679–1690

    CAS  PubMed  Google Scholar 

  • Rubinstein P, Dobrila L, Rosenfield RE, Adamson JW, Migliaccio G, Migliaccio AR et al (1995) Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci U S A 92(22):10119–10122

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rubinstein P, Carrier C, Scaradavou A, Kurtzberg J, Adamson J, Migliaccio AR et al (1998) Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 339(22):1565–1577

    Article  CAS  PubMed  Google Scholar 

  • Ruggeri A, Peffault de Latour R, Carmagnat M, Clave E, Douay C, Larghero J et al (2011) Outcomes, infections, and immune reconstitution after double cord blood transplantation in patients with high-risk hematological diseases. Transpl Infect Dis 13(5):456–465

    Article  CAS  PubMed  Google Scholar 

  • Ruggeri A, Rocha V, Masson E, Labopin M, Cunha R, Absi L, Boudifa A, Coeffic B, Devys A, De Matteis M, Dubois V, Hanau D, Hau F, Jollet I, Masson D, Pedron B, Perrier P, Picard C, Ramouneau-Pigot A, Volt F, Charron D, Gluckman E, Loiseau P (2013) Impact of donor-specific anti-HLA antibodies on graft failure and survival after reduced intensity conditioning-unrelated cord blood transplantation: a Eurocord, SFHI and SFGM-TC analysis. Haematologica 98(7):1154–1160

    Article  PubMed  PubMed Central  Google Scholar 

  • Ruggeri A, Labopin M, Sanz G, Piemontese S, Arcese W, Bacigalupo A, Blaise D, Bosi A, Huang H, Karakasis D, Koc Y, Michallet M, Picardi A, Sanz J, Santarone S, Sengelov H, Sierra J, Vincent L, Volt F, Nagler A, Gluckman E, Ciceri F, Rocha V, Mohty M (2015) Comparison of outcomes after unrelated cord blood and unmanipulated Haploidentical stem cell transplantation in adults with acute leukemia. Leukemia 29(9):1891–1900

    Article  CAS  PubMed  Google Scholar 

  • Sanz GF, Saavedra S, Planelles D, Senent L, Cervera J, Barragan E et al (2001) Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 98(8):2332–2338

    Article  CAS  PubMed  Google Scholar 

  • Scaradavou A, Brunstein CG, Eapen M, Le-Rademacher J, Barker JN, Chao N, Cuttler C, Delaney C, Kan F, Isola L, Karanes C, Laughlin MJ, Wagner JE, Shpall EJ (2013) Double unit grafts successfully extend the application of umbilical cord blood transplantation in adults with acute leukemia. Blood 121(5):752–758

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shpall EJ, Quinones R, Giller R et al (2002) Biol Blood Marrow Transplant 8(7):368–376

    Article  PubMed  Google Scholar 

  • Takanashi M, Atsuta Y, Fujiwara K, Kodo H, Kai S, Sato H et al (2010) The impact of anti-HLA antibodies on unrelated cord blood transplantations. Blood 116(15):2839–2846

    Article  CAS  PubMed  Google Scholar 

  • Verneris MR, Brunstein CG, Barker J, MacMillan ML, DeFor T, McKenna DH et al (2009) Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units. Blood 114(19):4293–4299

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wagner JE, Rosenthal J, Sweetman R, Shu XO, Davies SM, Ramsay NK et al (1996) Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood 88(3):795–802

    CAS  PubMed  Google Scholar 

  • Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C et al (2002) Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 100(5):1611–1618

    CAS  PubMed  Google Scholar 

  • Wagner JE Jr, Eapen M, Carter S, Wang Y, Schultz KR, Wall DA, Bunin N, Delaney C, Haut P, Margolis D, Peres E, Verneris MR, Walters M, Horowitz MM, Kurtzberg J, Blood and Marrow Transplant Clinical Trials Network (2014) One-unit versus two-unit cord-blood transplantation for hematologic cancers. N Engl J Med 371(18):1685–1694

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xia D, He HY, Lei ZM et al (2004) Surface fucolysation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrow. Blood 104(10):3091–3096

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eurocord, Hopital Saint Louis, 1 Avenue Claude Vellefaux 75475, Paris Cedex 10, France

    Eliane Gluckman MD, FRCP & Annalisa Ruggeri MD, PhD

  2. Monacord, Centre scientifique de Monaco, Monaco, France

    Eliane Gluckman MD, FRCP

  3. Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France

    Annalisa Ruggeri MD, PhD

Authors
  1. Eliane Gluckman MD, FRCP
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Annalisa Ruggeri MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eliane Gluckman MD, FRCP .

Editor information

Editors and Affiliations

  1. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Mitchell Horwitz

  2. Duke Cancer Center, Duke University, Durham, North Carolina, USA

    Nelson Chao

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Gluckman, E., Ruggeri, A. (2017). Historical Perspective and Current Trends of Umbilical Cord Blood Transplantation. In: Horwitz, M., Chao, N. (eds) Cord Blood Transplantations. Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-53628-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-53628-6_1

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-53627-9

  • Online ISBN: 978-3-319-53628-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation