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Manganese

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Metals and the Biology and Virulence of Brucella

Abstract

Brucella strains produce a single high affinity Mn transporter, MntH, and expression of the corresponding gene is regulated by the Mn-responsive transcriptional regulator Mur. Phenotypic analysis of a variety of mutants has shown that Mn-dependent enzymes play a crucial role in the basic physiology and virulence of Brucella strains, and suggest that these bacteria may also be modulate their cellular Mn content as a mechanism to resist oxidative stress.

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Acknowledgements

Work on Mn metabolism in Brucella in the laboratory of RMR has been funded by grants AI48499, AI63516 and AI112745 from the National Institute of Allergy and Infectious Disease and internal funding from the Office of Research and Graduate Studies, Brody School of Medicine, East Carolina University.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA

    R. Martin Roop II, Joshua E. Pitzer, John E. Baumgartner & Daniel W. Martin

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  1. R. Martin Roop II
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  2. Joshua E. Pitzer
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  3. John E. Baumgartner
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  4. Daniel W. Martin
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Correspondence to R. Martin Roop II .

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  1. Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA

    R. Martin Roop II

  2. Department of Biomedical Sciences and Pathobiology, Virginia–Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA

    Clayton C. Caswell

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Roop II, R.M., Pitzer, J.E., Baumgartner, J.E., Martin, D.W. (2017). Manganese. In: Roop II, R., Caswell, C. (eds) Metals and the Biology and Virulence of Brucella. Springer, Cham. https://doi.org/10.1007/978-3-319-53622-4_3

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