Abstract
Melanoma is a high malignant tumor with exceptionally variable morphologic appearance that can mimic different epithelioid and sarcomatoid tumors. Generally, the diagnosis of malignant melanoma must be based on the morphology, immunoprofile, and clinical data. In metastatic tumors with ambiguous morphology, it is always advisable to rule out melanoma.
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References
Karamchandani JR, Nielsen TO, van de Rijn M, West RB. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012;20(5):445–50.
Kang Y, Pekmezci M, Flope AL, et al. Diagnostic utility of SOX10 to distinguish malignant peripheral nerve sheath tumor from synovial sarcoma, including intraneural synovial sarcoma. Mod Pathol. 2014;27(1):55–61.
Cimino-Mathews A, Subhauwong AP, ALwood H, et al. Neural crest transcription factor Sox10 is preferentially expressed in triple-negative and metaplastic breast carcinomas. Hum Pathol. 2013;44(6):959–65.
Miettinen M, McCue PA, Sarlomo-Rikala M. Sox10- a marker for not only Schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue. Am J Surg Pathol. 2015;39:826–35.
Hseih M-S, Lee Y-H, Chang Y-L. Sox10 positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/carcinoma, and subgroup of mucoepidermoid carcinoma. Hum Pathol. 2016;56:134–42.
Perry B, Cohen C, Govindarajan B, et al. Wilms tumor 1 expression present in most melanomas but nearly absent in nevi. Arch Dermatol. 2006;142:1031–4.
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Tuffaha, M.S.A., Guski, H., Kristiansen, G. (2018). Markers and Immunoprofile of Melanocytic Tumors. In: Immunohistochemistry in Tumor Diagnostics. Springer, Cham. https://doi.org/10.1007/978-3-319-53577-7_21
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DOI: https://doi.org/10.1007/978-3-319-53577-7_21
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