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Markers and Immunoprofile of Endocrine and Neuroendocrine Tumors

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Immunohistochemistry in Tumor Diagnostics

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Abstract

Chromogranin, synaptophysin, NSE, S100, PGP9.5, CD56, PAX-6, and somatostatin receptor

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References

  1. Lee EB, Tihan T, Scheithauer BW, et al. Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker? J Neuropathol Exp Nerurol. 2009;68(5):482–8.

    Article  CAS  Google Scholar 

  2. Mete O, Lopes MB, Asa SL. Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. Am J Surg Pathol. 2013;37(11):1694–7.

    Article  PubMed  Google Scholar 

  3. Fischer S, Asa SL. Application of immunohistochemistry to thyroid neoplasms. Arch Pathol Lab Med. 2008;132:359–72.

    PubMed  Google Scholar 

  4. Nonaka D, Tang Y, Chiriboga L, et al. Diagnostic utility of thyroid transcription factors Pax8 and TTF2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol. 2008;21(2):192–200.

    CAS  PubMed  Google Scholar 

  5. Trerotola M, Cantanelli P, Guerra E, et al. Upregulation of trop-2 quantitatively stimulates human cancer. Oncogene. 2013;32(2):222–33.

    Article  CAS  PubMed  Google Scholar 

  6. El Demellawy D, Naser A, Babay S, Alowami S. Diagnostic utility of CD56 in papillary carcinoma of the thytoid. Pathol Res Pract. 2009;205(5):303–9.

    Article  CAS  PubMed  Google Scholar 

  7. Travis WD, Brambilla E, Noguchi M, et al. Diagnosis of lung adenocarcinoma in resected specimens. Arch Pathol Lab Med. 2012;136:1–23.

    Google Scholar 

  8. Roskams T, Willems M, Campos RV, et al. Parathyroid hormone-related peptide expression in primary and metastatic liver tumours. Histopathology. 1993;23:519–25.

    Article  CAS  PubMed  Google Scholar 

  9. Yamada M, Shiroeda H, Shiroeda S, et al. Cholangiocarcinoma producing parathyroid hormone related peptide treated with chemoradiation using gemcitabine and S1. Intern Med. 2009;48:2097–100.

    Article  PubMed  Google Scholar 

  10. Ordonez NG. Value of GATA3 Immunostaining in the diagnosis of parathyroid tumors. Appl Immunohistochem Mol Morphol. 2012;22(10):756–61.

    Article  Google Scholar 

  11. Weissfredt A, Phan A, Suster S, Moran CA. Adrenocortical carcinoma: a comprehensive immunohistochemical study of 40 cases. Appl Immunohistochem Mol Morphol. 2014;22(1):24–30.

    Article  Google Scholar 

  12. Chu PG, Lau SK, Weiss LM. Keratin expression in endocrine organs and their neoplasms. Endocr Pathol. 2009;20:1–10.

    Article  CAS  PubMed  Google Scholar 

  13. Sasano H, Suzuki T, Moriya T. Recent advances in histopathology and immunohistochemistry of adrenocortical carcinoma. Endocr Pathol. 2006;17:345–54.

    Article  CAS  PubMed  Google Scholar 

  14. Browning L, Bailey D, Parker A. D2-40 is a sensitive and specific marker in differentiating primary adrenal cortical tumours from both metastatic clear cell renal cell carcinoma and phaeochromocytoma. J Clin Pathol. 2008;61:293–6.

    Article  CAS  PubMed  Google Scholar 

  15. Xu B, Yang WH, Gerin I, et al. Dax-1and steroid receptor RNA activator (SRA) function as transcriptional coactivator for steroidogenic factor 1 in steroidogenesis. Mol Cell Biol. 2009;29(7):1719–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Suntharalingham JP, Buonocore F, Duncan AJ, et al. DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease. Best Pract Res Clin Endocrinol Metab. 2015;29(4):607–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Mendiola M, Carrillo J, Garcia E, et al. The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and highly expressed in Ewing tumors. Int J Cancer. 2006;118:1381–9.

    Article  CAS  PubMed  Google Scholar 

  18. Garcia-Aragoncillo E, Carrillo J, Lalli E, et al. DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing’s tumor cells. Oncogene. 2008;27:6034–43.

    Article  CAS  PubMed  Google Scholar 

  19. Arola J, Liu J, Heikkilä P, et al. Expression of inhibin alpha in the humal adrenal gland and adrenocortical tumors. Endocr Res. 1998;24(3–4):865–7.

    Article  CAS  PubMed  Google Scholar 

  20. de C Carvalho A, Parra ER, Zerbini MC, et al. Morphometric evaluation on NB84, Synaptophysin and AGNOR is useful for the histological diagnosis and prognosis in peripheral neuroblastic tumors (PNTS). Clinics. 2007;62:731–40.

    Article  Google Scholar 

  21. Miettinen M, Chatten J, Paetau A. Monoclonal antibody NB84 in the differential diagnosis of neuroblastoma and other small round cell tumors. Am J Surg Pathol. 1998;22:327–32.

    Article  CAS  PubMed  Google Scholar 

  22. Kontogianni K, Nicholson AG, Butcher D, Sheppard MN. CD56: a useful tool for the diagnosis of small cell lung carcinomas on biopsies with extensive crush artifact. J Clin Pathol. 2005;58:978–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Klimstra DS, Modlin IR, Adsay V, et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set. Am J Surg Pathol. 2010;34:300–13.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Carl-Thiem-Klinikum, Institut für Pathologie, Cottbus, Germany

    Muin S. A. Tuffaha

  2. Vivantes Klinikum Neukölln, Institut für Pathologie, Berlin, Germany

    Hans Guski

  3. Universität Bonn, UKB, Institut für Pathologie, Bonn, Germany

    Glen Kristiansen

Authors
  1. Muin S. A. Tuffaha
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  2. Hans Guski
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  3. Glen Kristiansen
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Tuffaha, M.S.A., Guski, H., Kristiansen, G. (2018). Markers and Immunoprofile of Endocrine and Neuroendocrine Tumors. In: Immunohistochemistry in Tumor Diagnostics. Springer, Cham. https://doi.org/10.1007/978-3-319-53577-7_14

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  • DOI: https://doi.org/10.1007/978-3-319-53577-7_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-53576-0

  • Online ISBN: 978-3-319-53577-7

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