Skip to main content

Markers and Immunoprofile of Renal and Urinary Tract Tumors

  • Chapter
  • First Online:
Immunohistochemistry in Tumor Diagnostics

Abstract

RCC, PAX-8, PAX-2, GATA-3, CD10, CD117, AMACR, human kidney injury molecule-1 (KIM-1), carbonic anhydrase IX (CAIX), TFE-3, DOG-1, cytokeratin profile, and vimentin [1, 2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mc G, David K, Khurana K, et al. Diagnosing primary and metastatic renal cell carcinoma. Am J Surg Pathol. 2001;25:1485–92.

    Article  Google Scholar 

  2. Zhao W, Tian B, Wu C, et al. DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. Pathol Res Pract. 2015;211(4):303–7.

    Article  CAS  PubMed  Google Scholar 

  3. Ordóñez NG. Value of PAX 8 immunostaining in tumor diagnosis: a review and update. Adv Anat Pathol. 2012;19(3):140–51.

    Article  PubMed  Google Scholar 

  4. Sangoi AR, Ohgami RS, Pai RK, et al. PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. Mod Pathol. 2011;24:412–24.

    Article  CAS  PubMed  Google Scholar 

  5. Tong G-X, Woojin MY, Beaubier NT, et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 2009;22:1218–12227.

    Article  CAS  PubMed  Google Scholar 

  6. Wang H-Y, Mills SE. KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. Am J Surg Pathol. 2005;29:640–6.

    Article  PubMed  Google Scholar 

  7. Avery AK, Beckstead J, Renshaw AA, et al. Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol. 2000;24:203–10.

    Article  CAS  PubMed  Google Scholar 

  8. Ordi J, Romagosa C. F A Tavassoli, et al. CD10 expression in epithelial tissues and tumors of the gynecologic tract. A useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol. 2003;2:178–86.

    Article  Google Scholar 

  9. Kuroda N, Guo L, Toi M, et al. Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma. Appl Immunohistochem Mol Morphol. 2001;9(4):315–8.

    CAS  PubMed  Google Scholar 

  10. Li G, Bilal I, Gentil-perret A, et al. CA9 as a molecular marker for differential diagnosis of cystic renal tumors. Urol Oncol. 2012;30(4):463–8.

    Article  PubMed  Google Scholar 

  11. Donato DPI, Johnson MT, Yang XJ, et al. Expression of carbonic anhydrase IX in genitourinary and adrenal tumours. Histopathology. 2011;59(6):1229–39.

    Article  PubMed  Google Scholar 

  12. Sangoi AR, Karamchandani J, Kim J, et al. The use of immunohistochemistry in the diagnosis of metastatic clear cell renal cell carcinoma: a review of PAX-8, PAX-2, hKIN-1, RCCma, CD10. Adv Anat Pathol. 2010;17(6):377–93.

    Article  CAS  PubMed  Google Scholar 

  13. Lin F, Zhang PL, Yang XJ, et al. Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma. Am J Surg Pathol. 2007;31(3):371–81.

    Article  PubMed  Google Scholar 

  14. Alexiev BA. Renal cell carcinoma associated with Xp11.2 translocation/transcription factor E3 (TFE3) fusion. J Cytol Histol. 2013;4(2):173.

    Article  Google Scholar 

  15. Wu X-R, Lin J-H, Walzg T, et al. Mammalian uroplakins: a group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem. 1994;269:13716–24.

    CAS  PubMed  Google Scholar 

  16. Lobban ED, Smith BA, Hall GD, et al. Uroplakin gene expression by normal and neoplastic human urothelium. Am J Pathol. 1998;153:1957–67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Yuasa T, Yoshiki T, Isono T, et al. Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. Int J Urol. 1999;6:286–92.

    Article  CAS  PubMed  Google Scholar 

  18. Kaufmann JV, Dietel M. Uroplakin III is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Am J Clin Pathol. 2000;113:683–7.

    Article  CAS  PubMed  Google Scholar 

  19. Higgs JP, Kaygusuz G, Wang L, et al. Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007;31(5):673–80.

    Article  Google Scholar 

  20. Esheba GE, Longacre TA, Atkins KA, et al. Expression of the urothelial differentiation markers GATA3 and Placental S100 (S100P) in female genital tract transitional cell proliferations. Am J Surg Pathol. 2009;33(3):347–53.

    Article  PubMed  Google Scholar 

  21. Ellis CL, Chang AG, Cimino-Mathews A, et al. GATA-3 expression in the differential diagnosis of adenocarcinoma of the urinary bladder. Am J Surg Pathol. 2013;37:1756–60.

    Article  PubMed  Google Scholar 

  22. Rao Q, Williamson SR, Lopez-Beltran A, et al. Distinguishing primary adenocarcinoma of the urinary bladder from secondary involvement by colorectal adenocarcinoma: extended immunohistochemical profiles emphasizing novel markers. Mod Pathol. 2013;26:725–32.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Tuffaha, M.S.A., Guski, H., Kristiansen, G. (2018). Markers and Immunoprofile of Renal and Urinary Tract Tumors. In: Immunohistochemistry in Tumor Diagnostics. Springer, Cham. https://doi.org/10.1007/978-3-319-53577-7_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-53577-7_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-53576-0

  • Online ISBN: 978-3-319-53577-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics