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Asbestos and Mesothelioma pp 161–174Cite as

Asbestos-Induced Inflammation in Malignant Mesothelioma and Other Lung Diseases

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

Asbestos exposure can lead to many lung and mesothelial cell diseases, including fibrosis and malignant mesothelioma. These are devastating diseases that are difficult to treat due to the long latency period and lack of predictive markers. Available literature shows that there is consensus among researchers that inflammation plays a significant role in the development of these diseases. Furthermore, there is a potential that early inflammatory signatures could be exploited as biomarkers for diagnosis and targets for treatment. This chapter reviews recent information, ranging from experimental disease models to asbestos-exposed individuals, that suggests a critical role for asbestos-induced inflammation in disease causation; this information has implications for the identification of novel predictive biomarkers and therapeutic targets to aid in early diagnosis and treatment of asbestos-associated diseases.

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Acknowledgements

This work is supported by a grant from NIEHS (RO1ES021110) and a Pathology and Laboratory Medicine fellowship.

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The authors have no conflicts of interest to disclose.

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  1. Department of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT, 05405, USA

    Joyce K. Thompson & Arti Shukla

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  1. Joyce K. Thompson
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  2. Arti Shukla
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Correspondence to Arti Shukla .

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  1. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Joseph R. Testa

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Thompson, J.K., Shukla, A. (2017). Asbestos-Induced Inflammation in Malignant Mesothelioma and Other Lung Diseases. In: Testa, J. (eds) Asbestos and Mesothelioma. Current Cancer Research. Springer, Cham. https://doi.org/10.1007/978-3-319-53560-9_7

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  • DOI: https://doi.org/10.1007/978-3-319-53560-9_7

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