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Mesothelioma Pathology

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Asbestos and Mesothelioma

Part of the book series: Current Cancer Research ((CUCR))

Abstract

Malignant mesothelioma can arise from pleura, peritoneum, pericardium, and the tunica vaginalis. It has the propensity to encase organs with rind-like growth over serosal surfaces and can demonstrate a variety of histomorphologic growth patterns ranging from epithelial to sarcomatoid. Given such, securing a diagnosis of malignant mesothelioma entails proper gross distribution of tumor in combination with histomorphology compatible with mesothelioma and exclusion of another primary source metastatic to the serosal cavity through immunohistochemistry. While employed less often, electron microscopy still holds value in distinguishing epithelioid malignancies from malignant epithelial mesothelioma. Recent studies have shown BAP1 immunohistochemistry in conjunction with fluorescence in-situ hybridization for homozygous loss of the gene encoding 16INK4A to be beneficial in separating benign/reactive from malignant mesothelial proliferations.

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Authors and Affiliations

  1. Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA

    Elizabeth N. Pavlisko, John M. Carney, Thomas A. Sporn & Victor L. Roggli

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  1. Elizabeth N. Pavlisko
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  2. John M. Carney
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  3. Thomas A. Sporn
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  4. Victor L. Roggli
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Correspondence to Victor L. Roggli .

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  1. Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Joseph R. Testa

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Pavlisko, E.N., Carney, J.M., Sporn, T.A., Roggli, V.L. (2017). Mesothelioma Pathology. In: Testa, J. (eds) Asbestos and Mesothelioma. Current Cancer Research. Springer, Cham. https://doi.org/10.1007/978-3-319-53560-9_6

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  • DOI: https://doi.org/10.1007/978-3-319-53560-9_6

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