Abstract
Ionizing radiotherapy (RT) and non-ionizing radiotherapy (photodynamic therapy, PDT) play important roles in both the palliative and definitive treatment settings for patients with malignant pleural mesothelioma (MPM). As the technological sophistication of RT planning and delivery devices increases, the ability of RT to provide durable local control has become increasingly important. Similarly, PDT, which combines a photosensitizer, light, and molecular oxygen, is increasingly being used to treat thoracic malignancies, including MPM. This chapter discusses the mechanistic and logistical basics of RT and PDT and the use of these therapies in the increasingly multidisciplinary care of patients with MPM. In addition, the major clinical trials that support the use of RT and PDT in the care of patients with MPM are reviewed and discussed. Finally, the potential for future improvements and new directions for RT and PDT is described.
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Simone, C.B., Busch, T.M., Cengel, K.A. (2017). Radiotherapy and Photodynamic Therapy for Malignant Pleural Mesothelioma. In: Testa, J. (eds) Asbestos and Mesothelioma. Current Cancer Research. Springer, Cham. https://doi.org/10.1007/978-3-319-53560-9_14
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