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Gene Transfer Strategies for Articular Cartilage Repair

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Cartilage

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Abstract

Gene therapy protocols are well suited to deliver genes coding for therapeutic factors over time in a spatially defined manner within sites of cartilage injury resulting from acute trauma or during osteoarthritis. The focus of this chapter is to examine the benefits of gene therapy to improve cartilage repair in such lesions, based on promising experimental and clinical evidence in relevant models in vivo using growth, transcription, and signalling factors capable of stimulating the chondrogenic and chondro-reparative processes locally. A continuous, combined effort between scientists and orthopaedic surgeons may allow to bring gene therapy from encouraging data at the bench to a successful, safe translation in the broadly affected human population.

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  1. Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr. Bldg 37, 66421, Homburg, Saar, Germany

    Magali Cucchiarini

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  1. Magali Cucchiarini
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Correspondence to Magali Cucchiarini .

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  1. Orthopädische Klinik für die Universität Regensburg, Universitätsklinikum Regensburg, Regensburg, Germany

    Susanne Grässel

  2. Department of General, Trauma, and Reconstruction Surgery, Ludwig-Maximilians-University, Munich, Germany

    Attila Aszódi

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Cucchiarini, M. (2017). Gene Transfer Strategies for Articular Cartilage Repair. In: Grässel, S., Aszódi, A. (eds) Cartilage. Springer, Cham. https://doi.org/10.1007/978-3-319-53316-2_9

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