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Male Hypogonadism Due to Cancer and Cancer Treatments

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Male Hypogonadism

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Survival rates after cancer treatment have increased dramatically in recent decades, resulting in an increasing focus on the harmful effects of cancer treatment for these patients. One of the major long-term effects of cancer and its treatment is compromised reproductive function in both males and females. These effects may occur as a result of direct effects on the gonad or indirect effects via damage to the hypothalamus or pituitary. In males, there may be impairment of testicular function prior to the commencement of treatment while the direct effects of exposure to cytotoxic therapies may also damage the seminiferous epithelium leading to oligo- or azoospermia. In addition to effects on the germ cells, Leydig cell dysfunction may occur, resulting in impaired testosterone production. This chapter describes the effects of cancer and its treatment on male reproductive function in terms of damage to the seminiferous epithelium and testosterone production. We also discuss the options, both established and experimental, for fertility preservation in these patients.

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Authors and Affiliations

  1. MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, Lothian, EH164TJ, Scotland, UK

    Rod T. Mitchell BSc, MBChB, PhD

  2. Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Nordfertil Research Lab Stockholm, Pediatric Endocrinology Unit, Q2:08, Stockholm, 17176, Sweden

    Jan-Bernd Stukenborg MSc, PhD

  3. Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, Helsinki University Central Hospital, University of Helsinki, PL281, Helsinki, 00029, Finland

    Kirsi Jahnukainen MD, PhD

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  1. Rod T. Mitchell BSc, MBChB, PhD
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  2. Jan-Bernd Stukenborg MSc, PhD
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  3. Kirsi Jahnukainen MD, PhD
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Correspondence to Kirsi Jahnukainen MD, PhD .

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Editors and Affiliations

  1. Department of Medicine, Endocrinology, D, University of Louisville Health Sciences, Louisville, USA

    Stephen J. Winters

  2. Department of Surgery and Cancer, Imperial College London, London, United Kingdom

    Ilpo T. Huhtaniemi

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Mitchell, R.T., Stukenborg, JB., Jahnukainen, K. (2017). Male Hypogonadism Due to Cancer and Cancer Treatments. In: Winters, S., Huhtaniemi, I. (eds) Male Hypogonadism. Contemporary Endocrinology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-53298-1_12

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