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Brain Aging in the Dog

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Canine and Feline Dementia

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Abstract

Dogs develop behavioral and cognitive dysfunction with age. Interestingly, as with humans, not all aged dogs become impaired, and there can be significant individual variability. Studies of the brains of cognitively characterized aged dogs suggest several possible underlying neurobiological mechanisms for observed impairments. In this chapter, changes in canine brains associated with atrophy, neuron loss, accumulation of beta-amyloid (Aβ), mitochondrial dysfunction, and resulting accumulation of oxidative damage are described. There are many important features of brain aging in dogs that overlap significantly with human brain aging, suggesting they are a useful model system in which to test interventions that may lead to healthy aging.

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Acknowledgment

Funding provided by the NIH/NIA R01AG0031764.

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Authors and Affiliations

  1. Veterinary Emergency and Specialty Centers of New Mexico, Albuquerque, NM, 87109, USA

    Jeff Nichol

  2. Sanders-Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, 40536, USA

    Elizabeth Head

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  1. Jeff Nichol
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Correspondence to Elizabeth Head .

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Editors and Affiliations

  1. North Toronto Veterinary Behaviour, Specialty Clinic, Thornhill, Ontario, Canada

    Gary Landsberg

  2. Univ of Veterinary Medicine and Pharmacy, Small Animal Clinic, Košice, Slovakia

    Aladár Maďari

  3. Slovak Academy of Sciences, Institute of Neuroimmunology, Bratislava, Slovakia

    Norbert Žilka

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Nichol, J., Head, E. (2017). Brain Aging in the Dog. In: Landsberg, G., Maďari, A., Žilka, N. (eds) Canine and Feline Dementia. Springer, Cham. https://doi.org/10.1007/978-3-319-53219-6_5

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