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Direct Bacterial Infection of the Renal Parenchyma: Pyelonephritis in Native Kidneys

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Bacterial Infections and the Kidney

Abstract

Acute pyelonephritis is a common disorder prevalently affecting young women, that may be severe in the elderly, in diabetics, in pregnant women and in immunosuppressed patients. The aim of this chapter is to try to elucidate some nebulous points, also through our own experience, regarding the relationship with vesico-ureteral reflux in adults, the frequency of complication with abscesses, the need for CT or magnetic resonance imaging, the long-term evolution. Acute pyelonephritis (APN) in the native kidney is a common disorder prevalently affecting young women. It is responsible for more than 100,000 hospitalizations per year in the U.S. APN is usually a benign disease, but it may be severe in the elderly, in diabetics, in pregnant women, and in immunosuppressed patients. Complicated APN may present renal abscesses or transformation into emphysematous pyelonephritis (EP). A pathogenic role is played by sexual activity, genetic predisposition, and urinary instrumentation. The correlation between APN and vesicoureteral reflux (VUR) in adults has not been clearly determined. The most common etiologic agent both in adults and in children is Escherichia coli. Diagnosis of APN is mainly clinical, but only CT or magnetic resonance are able to establish the exact definition and extent of the renal parenchymal lesions and to detect abscesses. The frequency of abscesses is largely underestimated in the literature and in clinical practice. The most severe cases of APN should be treated, at least at the onset, with parenteral antibiotics, and the patients should be hospitalized. Antibiotic treatment should include fluoroquinolone or a broad spectrum cephalosporin associated or not with an aminoglycoside for 10–14 days. Abscesses require longer treatment, and drainage may be necessary in large ones. The long-term evolution of APN seems favorable, even though cortical scar formation, development of proteinuria, or renal failure have been reported.

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References

  1. http://cid.oxfordjournals.org/content/40/5/643.full.pdf+html.

  2. Hooton T. Acute complicated cystitis and pyelonephritis. Up-to-Date March 2016.

    Google Scholar 

  3. Hooton T, Gupta K. Recurrent urinary tract infection in women. Up-to-Date April 2016.

    Google Scholar 

  4. Ramakrishnan K, Scheid DC. Diagnosis and management of acute pyelonepritis in adult. Am Family Physician. 2005;71:933–42.

    Google Scholar 

  5. Brown P, Ki M, Foxman B. Acute pyelonephritis among adults: cost of illness and considerations for the economic evaluation of therapy. Pharmacoeconomics. 2005;23:1123–42.

    Article  PubMed  Google Scholar 

  6. McDonald H, Nitsch D, Millett ER, et al. New estimates of the burden of acute community-acquired infections among older people with diabetes mellitus: a retrospective cohort study using linked electronic health records. Diabet Med. 2014;31:606–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Wing DA, Fassett MJ, Getahun D. Acute pyelonephritis in pregnancy: an 18-year retrospective analysis. Am J Obstet Gynecol. 2014;210:219–25.

    Article  PubMed  Google Scholar 

  8. Yen DH, Hu SC, Tsai J, et al. Renal abscess: early diagnosis and treatment. Am J Emerg Med. 1999;17:192–8.

    Article  CAS  PubMed  Google Scholar 

  9. Fowler JE Jr, Perkins T. Presentation, diagnosis and treatment of renal abscesses: 1972–1988. J Urol. 1994;151:847–52.

    PubMed  Google Scholar 

  10. Sobel JD, Kaye D. Urinary tract infections. In: Churchill Livingstone Inc edited by Mandell Douglas and Bennett’s principles and practice of infectious diseases—fourth edition, 1995. p. 662–90.

    Google Scholar 

  11. Rollino C, Beltrame G, Ferro M, et al. Acute pyelonephritis in adults: a case series of 223 patients. Nephrol Dial Transplant. 2012;27:3488–93.

    Article  PubMed  Google Scholar 

  12. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European society for microbiology and infectious diseases. Clin Infect Dis. 2011;52:e103–20.

    Article  PubMed  Google Scholar 

  13. Hooton TM, Roberts PL, Cox M, et al. Voided midstream urine culture and acute cystitis in premenopausal women. N Engl J Med. 2013;14(369):1883–91.

    Article  Google Scholar 

  14. Scholes D, Hooton TM, Roberts PL, et al. Risk factors associated with acute pyelonephritis in healthy women. Ann Intern Med. 2005;142:20–7.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bass PF, Jarvis JA, Mitchell CK. Urinary tract infections. Prim Care. 2003;30:41–61.

    Article  PubMed  Google Scholar 

  16. Nahar A, Akom M, Hanes D, et al. Pyelonephritis and acute renal failure. Am J Med Sci. 2004;328:121–3.

    Article  PubMed  Google Scholar 

  17. Efstathiou SF, Pefanis AV, Tsioulos DI, et al. Acute pyelonephritis in adults: prediction of mortality and failure of treatment. Arch Int Med. 2003;163:1206–12.

    Article  Google Scholar 

  18. Chen Y, Nitzan O, Saliba W, et al. Are blood cultures necessary in the management of women with complicated pyelonephritis? J Infect. 2006;53:235–40.

    Article  PubMed  Google Scholar 

  19. Hooton TM. Clinical practice. Uncomplicated urinary tract infection. N Engl J Med. 2012;15:366–73.

    Google Scholar 

  20. Velasco M, Martinez JA, Moreno-Maretinez A, et al. Blood culture for women with uncomplicated acute pyelonephritis: are they necessary? Clin Infec Dis. 2003;37:1127–30.

    Article  Google Scholar 

  21. Rubini RH, Shapiro ED, Andriole VT, et al. Evaluation of new anti-infective drugs for the treatment of urinary tract infection. Infectious Disease Society of America and Food and Drug Administration. Clin Infec Dis. 1992;15:S216–227.

    Google Scholar 

  22. Kavashima A, Le Roy AJ. Radiologic evaluation of patients with renal infections. Infect Dis Clin North Am. 2003;17:433–56.

    Article  Google Scholar 

  23. Roberts KB. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics. 2011;128:595–610.

    Article  PubMed  Google Scholar 

  24. Majd M, Nussbaum Blask AR, Markle BM, et al. Acute pyelonephritis: comparison of diagnosis with 99mTc-DMSA, SPECT, spiral CT, MR imaging, and power Doppler US in an experimental pig model. Radiology. 2001;218:101–8.

    Article  CAS  PubMed  Google Scholar 

  25. Piccoli GB, Consiglio V, Deagostini MC, et al. The clinical and imaging presentation of acute “non complicated” pyelonephritis: a new profile for an ancient disease. BMC Nephrol. 2011;29:48–56.

    Article  Google Scholar 

  26. Mesiano P, Rollino C, Beltrame G, et al. Acute renal infarction: a single center experience. J Nephrol. 2016 Jan 7. [Epub ahead of print].

    Google Scholar 

  27. Piccoli GB, Priola AM, Vigotti FN, et al. Renal infarction versus pyelonephritis in a woman presenting with fever and flank pain. Am J Kidney Dis. 2014;64:311–4.

    Article  PubMed  Google Scholar 

  28. Smaill FM, Vazquez JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev. 2015 Aug 7;8:CD000490.

    Google Scholar 

  29. Boyko EJ, Fihn SD, Scholes D, et al. Risk of urinary tract infection and asymptomatic bacteriuria among diabetic and nondiabetic postmenopausal women. Am J Epidemiol. 2005;161:557–64.

    Article  PubMed  Google Scholar 

  30. Ronald A, Ludwig E. Urinary tract infections in adults with diabetes. Int J Antimicrob Agents. 2001;17:287–92.

    Article  CAS  PubMed  Google Scholar 

  31. Geerlings SE, Meiland R, van Lith EC, et al. Adherence of type 1-fimbriated Escherichia coli to uroepithelial cells: more in diabetic women than in control subjects. Diabetes Care. 2002;25:1405–9.

    Article  PubMed  Google Scholar 

  32. Kumar S, Ramachandran R, Mete U, et al. Acute pyelonephritis in diabetes mellitus: single center experience. Indian J Nephrol. 2014;24:367–71.

    Google Scholar 

  33. Huang A, Palmer LS, Hom D, et al. Ibuprofen combined with antibiotics suppresses renal scarring due to ascending pyelonephritis in rats. J Urol. 1999;162:1396–8.

    Article  CAS  PubMed  Google Scholar 

  34. Somani BK, Nabi G, Thorpe P, et al. Is percutaneous drainage the new gold standard in the management of emphysematous pyelonephritis? Evidence from a systematic review. J Urol. 2008;179:1844–9.

    Article  PubMed  Google Scholar 

  35. Benson A, Kim ED. Medscape reference. Renal corticomedullary abscess. Clinical Presentation. Updated 22 October 2013.

    Google Scholar 

  36. Ko MC, Chiu AW, Liu CC, et al. Effect of diabetes on mortality and length of hospital stay in patients with renal or perinephric abscess. Clinics. 2013;68:1109–11.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Bammer R. Basic principles of diffusion-weighted imaging. Eur J Radiol. 2003;45:169–84.

    Article  PubMed  Google Scholar 

  38. Rathod SB, Kumbhar SS, Nanivadekar A, et al. Role of diffusion-weighted MRI in acute pyelonephritis: a prospective study. Acta Radiol. 2015;56:244–9.

    Article  PubMed  Google Scholar 

  39. Faletti R, Cassinis MC, Fonio P, et al. Diffusion-weighted imaging and apparent diffusion coefficient values versus contrast-enhanced MR imaging in the identification and characterisation of acute pyelonephritis. Eur Radiol. 2013;23:3501–8.

    Google Scholar 

  40. Jennette JC, Olson JL, Schwartz MM, et al. Primer of the pathologic diagnosis of renal disease. Heptinstall’s Pathology of the Kidney, Volume 1. Ed. Lippincott Williams and Wilkins. 2007; p. 117–9.

    Google Scholar 

  41. Choi YD, Yang WJ, Do SH, et al. Vesicoureteral reflux in adult women with uncomplicated acute pyelonephritis. Urology. 2005;66:55–8.

    Article  PubMed  Google Scholar 

  42. Manunta A, Patard JJ, Guillé F, et al. Recurrent pyelonephritis without vesicoureteral reflux: is there a role for an antireflux procedure? Endourol. 2001;15:707–10.

    Article  CAS  Google Scholar 

  43. Grabe M, Bjerklund-Johansen TE, Botto H. Guidelines on urological infections. European Association of Urology 2011. http://www.uroweb.org/gls/pdf/15_Urological_Infections.

  44. Scottish Intecollegiate Guidelines Network. Management of suspected bacterial urinary tract. http://www.sign.ac.uk/pdf/sign88.

  45. Rubinstein E, Keynan Y. Short-course therapy for severe infections. Int J Antimicrob Agents. 2013;42:S22–4.

    Article  CAS  PubMed  Google Scholar 

  46. Behr MA, Drummond R, Libman MD, et al. Fever duration in hospitalized acute pyelonephritis patients. Am J Med. 1996;101:277–80.

    Article  CAS  PubMed  Google Scholar 

  47. Prahbu A, Taylor P, Konecny P, et al. Pyelonephritis: what are the present day causative organisms and antibiotic susceptibilities? Nephrology. 2013;18:463–7.

    Article  Google Scholar 

  48. Korzets Z, Plotkin E, Bernheim J, et al. The clinical spectrum of acute renal infarction. Isr Med Assoc J. 2002;4:781–4.

    PubMed  Google Scholar 

  49. Bergeron MG. Treatment of pyelonephritis in adults. Med North Am. 1995;79:619–49.

    Article  CAS  Google Scholar 

  50. Sandberg T, Skoog G, Hermansson AB, et al. Ciprofloxacin for 7 days versus 14 days in women with acute pyelonephritis: a randomised, open-label and double-blind, placebo-controlled, non-inferiority trial. Lancet. 2012;4:484–90.

    Article  Google Scholar 

  51. Kyriakidou KG, Rafailidis P, Matthaiou DK. Short- versus long-course antibiotic therapy for acute pyelonephritis in adolescents and adults: a meta-analysis of randomized controlled trials. Clin Ther. 2008;30:1859–68.

    Article  CAS  PubMed  Google Scholar 

  52. Eliakim-Raz N, Yahav D, Paul M, et al. Duration of antibiotic treatment for acute pyelonephritis and septic urinary tract infection: 7 days or less versus longer treatment: systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother. 2013;68:2183–91.

    CAS  PubMed  Google Scholar 

  53. Graham JM, Oshiro BT, Blanco JD, et al. Uterine contractions after antibiotic therapy for pyelonephritis in pregnancy. Am J Obstet Gynecol. 1993;168:577–80.

    Article  CAS  PubMed  Google Scholar 

  54. Abdul-Halim H, Kehinde EO, Abdeen S, et al. Severe emphysematous pyelonephritis in diabetic patients: diagnosis and aspects of surgical management. Urol Int. 2005;75:123–8.

    Article  PubMed  Google Scholar 

  55. Dembry LM, Andriole VT. Renal and perirenal abscesses. Infect Dis Clin North Am. 1997;11:663–8.

    Article  CAS  PubMed  Google Scholar 

  56. Siegel JF, Smith A, Moldwin R. Minimally invasive treatment of renal abscess. J Urol. 1996;155:52–5.

    Article  CAS  PubMed  Google Scholar 

  57. Lipsky BA. Prostatitis and urinary tract infection in men: what’s new, what’s true? Am J Med. 1999;106:327–34.

    Article  CAS  PubMed  Google Scholar 

  58. Cotton SA, Gbadegesin RA, Williams S, et al. Role of TGF-beta1 in renal parenchymal scarring following childhood urinary tract infection. Kidney Int. 2002;61:61–7.

    Article  CAS  PubMed  Google Scholar 

  59. Gbadegesin RA, Cotton SA, Watson CJ, et al. Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection. Int J Immunogenet. 2006;33:49–53.

    Article  CAS  PubMed  Google Scholar 

  60. Saemann MD, Weichhart T, Horl WH, et al. Tamm-Horsfall protein: a multilayered defence molecule against urinary tract infection. Eur J Clin Invest. 2005;35:227–35.

    Article  CAS  PubMed  Google Scholar 

  61. Bates JM, Raffi HM, Prasadan L, et al. Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int. 2004;65:791–7.

    Article  CAS  PubMed  Google Scholar 

  62. Pohl HG, Rushton HG, Park JS, et al. Adjunctive oral corticosteroids reduce renal scarring: the piglet model of reflux and acute experimental pyelonephritis. J Urol. 1999;162:815–20.

    Article  CAS  PubMed  Google Scholar 

  63. Huang JJ, Tseng CC. Emphysematous pyelonephritis: Clinicoradiological classification, management, prognosis, and pathogenesis. Arch Intern Med. 2000;160:797–805.

    Article  CAS  PubMed  Google Scholar 

  64. Khalil A, Tullus K, Bakhiet M, et al. Angiotensin II type 1 receptor antagonist (losartan) down-regulates transforming growth factor-beta in experimental acute pyelonephritis. J Urol. 2000;164:186–91.

    Article  CAS  PubMed  Google Scholar 

  65. Raz R, Sakran W, Chazan B, et al. Long-term follow-up of women hospitalized for acute pyelonephritis. Clin Infec Dis. 2003;37:1014–20.

    Article  Google Scholar 

  66. Meyrier A, Guibert J. Diagnosis and drug treatment of acute pyelonephritis. Drugs. 1992;44:56–9.

    Article  Google Scholar 

  67. Mitterberger M, Pinggera GM, Feuchtner G. Acute pyelonephritis: comparison of diagnosis with CT and contrast enhanced ultrasound. BJU Int. 2008;101:341–4.

    Article  PubMed  Google Scholar 

  68. Granata L, Andrulli S, Fiorini F, et al. Diagnosis of APN by contrast-enhanced ultrasonography in kidney transplant patients. Nephrol Dial Transplant. 2011;26:715–20.

    Google Scholar 

  69. Montini G, Tullus K, Hewitt I. Febrile urinary tract infections in children. N Engl J Med. 2011;365:239–50.

    Article  CAS  PubMed  Google Scholar 

  70. Mårild S, Jodal U. Incidence rate of first-time symptomatic urinary tract infection in children under 6 years of age. Acta Paediatr. 1998;87:549–52.

    Article  PubMed  Google Scholar 

  71. Alberici I, Bayazit AK, Drozdz D, et al. Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group. Eur J Pediatr. 2014;174:783–90.

    Article  PubMed  Google Scholar 

  72. Morello W, La Scola C, Alberici I, et al. Acute pyelonephritis in children. Pediatr Nephrol. 2016;31:1253–65.

    Article  PubMed  Google Scholar 

  73. National Institute for Health and Clinical Excellence Urinary tract infection in children: diagnosis, treatment and long-term management; 2007. Available at: https://www.nice.org.uk/Guidance/cg54.

  74. Vaillancourt S, McGillivray D, Zhang X, Kramer MS. To clean or not to clean: effect on contamination rates in midstream urine collections in toilet-trained children. Pediatrics. 2007;119:e1288–93.

    Article  PubMed  Google Scholar 

  75. Altuntas N, Celebi Tayfur A, Kocak M, et al. Midstream clean-catch urine collection in newborns: a randomized controlled study. Eur J Pediatr. 2014;174:577–82.

    Article  PubMed  Google Scholar 

  76. Stein R, Dogan HS, Hoebeke P, et al. Urinary tract infections in children: EAU/ESPU guidelines. Eur Urol. 2015;67:546–58.

    Article  PubMed  Google Scholar 

  77. Leroy S, Fernandez-Lopez A, Nikfar R, et al. Association of procalcitonin with acute pyelonephritis and renal scars in pediatric UTI. Pediatrics. 2013;131:870–9.

    Article  PubMed  Google Scholar 

  78. Pecile P, Miorin E, Romanello C, et al. Procalcitonin: a marker of severity of acute pyelonephritis among children. Pediatrics. 2004;114:e249–54.

    Article  PubMed  Google Scholar 

  79. Ardissino G, Daccò V, Testa S, et al. Epidemiology of chronic renal failure in children: data from the ItalKid project. Pediatrics. 2003;111:e382–7.

    Article  PubMed  Google Scholar 

  80. North American Pediatric Renal Trials and Collaborative Studies. Annual report, 2008. Available at: https://web.emmes.com/study/ped.

  81. Strohmeier Y, Hodson EM, Willis NS, Webster AC, Craig JC, Antibiotics for acute pyelonephritis in children. Cochrane Database Syst Rev. 2014;CD003772.

    Google Scholar 

  82. Ammenti A, Cataldi L, Chimenz R, et al. Febrile urinary tract infections in young children: recommendations for the diagnosis, treatment and follow-up. Acta Paediatr. 2012;101:451–7.

    Article  PubMed  Google Scholar 

  83. Hoberman A, Greenfield SP, Mattoo TK, et al. Antimicrobial prophylaxis for children with vesicoureteral reflux. NewEngland J med. 2014;370:2367–76.

    Google Scholar 

  84. López-Novoa JM, Rodríguez-Peña AB, Ortiz A, at al. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clin Impl J Transl Med. 2011;9:13–8.

    Google Scholar 

  85. Braden GL, O’Shea MH, Mulhern JG. Tubulointerstitial Diseases. AJKD. 2005;46:560–72.

    Article  PubMed  Google Scholar 

  86. Fogo AB. Causes and pathogenesis of focal segmental glomerulosclerosis. Nat Rev Nephrol. 2015;11:76–87.

    Article  CAS  PubMed  Google Scholar 

  87. Fogo A. Atlas of the Kidney. Am J Kidney Dis. 2000;35:E7–8.

    Article  Google Scholar 

  88. Meyrier A. Xanthogranulomatous pyelonephritis. Up-to-date 2015.

    Google Scholar 

  89. Rao AG, Eberts PT. Xanthogranulomatous pyelonephritis: an uncommon pediatric renal mass. Pediatr Radiol. 2011;41:671–9.

    Article  PubMed  Google Scholar 

  90. Kim SW, Yoon BI, Ha US, et al. Xanthogranulomatous pyelonephritis: clinical experience with 21 cases. J Infect Chemother. 2013;19:1221–4.

    Article  CAS  PubMed  Google Scholar 

  91. Addison B, Zargar H, Lilic N, et al. Analysis of 35 cases of xanthogranulomatous pyelonephritis. ANZ J Surg. 2015;85:150–3.

    Article  PubMed  Google Scholar 

  92. Tan WP, Papagiannopoulos D, Elterman L. Bear’s paw sign: a classic presentation of xanthogranulomatous pyelonephritis. Urology. 2015;86:e5–6.

    Article  PubMed  Google Scholar 

  93. Chang CP, Wang SS, Wen MC, et al. Mucinous adenocarcinoma of the renal pelvis masquerading as xanthogranulomatous pyelonephritis. Urology. 2013;81:e40–1.

    Article  PubMed  Google Scholar 

  94. Purnell SD, Davis B, Burch-Smith R, et al. Renal malakoplakia mimicking a malignant renal carcinoma: a patient case with literature review. BMJ Case Rep 2015;15.

    Google Scholar 

  95. Kim J. Ultrasonographic features of focal xanthogranulomatous pyelonephritis. J Ultrasound Med. 2004;23:409–16.

    Article  PubMed  Google Scholar 

  96. Arrighi N, Antonelli A, Zani D, et al. Renal mass with caval thrombus as atypical presentation of xantogranulomatous pyelonephritis. A case report and literature review. Urologia. 2013;24;80 Suppl 22:44–7.

    Google Scholar 

  97. Taskinen S, Giordano S, Rintala R. Xanthogranulomatous pyelonephritis infiltrating the liver. J Pediatr Surg. 2008;43:e7–9.

    Article  PubMed  Google Scholar 

  98. Li L, Parwani AV. Xanthogranulomatous pyelonephritis. Arch Pathol Lab Med. 2011;135:671–4.

    PubMed  Google Scholar 

  99. Korkes F, Favoretto RL, Bróglio M, et al. Xanthogranulomatous pyelonephritis: clinical experience with 41 cases. Urology. 2008;71:178–80.

    Article  PubMed  Google Scholar 

  100. Guzzo TJ, Bivalacqua TJ, Pierorazio PM, et al. Xanthogranulomatous pyelonephritis: presentation and management in the era of laparoscopy. BJU Int. 2009;104:1265–9.

    Article  PubMed  Google Scholar 

  101. Daroux M, Frimat M, Mirault T, et al. Renal malakoplakia: an underestimate cause of renal failure. Nephrol Ther. 2011;7:111–6.

    Article  PubMed  Google Scholar 

  102. Purnell SD, Davis B, Burch-Smith R, et al. Renal malakoplakia mimicking a malignant renal carcinoma: a patient case with literature review. BMJ Case Rep. 2015;15:2015. pii: bcr2014208652.

    Google Scholar 

  103. Warren JW, Abrutyn E, Hebel JR, et al. Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Clin Infect Dis. 1999;29:745–58.

    Article  CAS  PubMed  Google Scholar 

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  1. Nephrology and Dialysis, S. Giovanni Bosco Hospital, Piazza Donatore di Sangue 3, 10154, Turin, Italy

    Cristiana Rollino, Giulietta Beltrame, Michela Ferro, Giacomo Quattrocchio & Dario Roccatello

  2. Radiology, S. Giovanni Bosco Hospital, Turin, Italy

    Manuela Sandrone

  3. Nephrology Dialysis Transplantation, Regina Margherita Children’s Hospital, Turin, Italy

    Licia Peruzzi, Roberta Camilla, Francesca Mattozzi & Bruno Gianoglio

  4. Division of Pathology, S. Giovanni Bosco Hospital, Turin, Italy

    Andrea De Marchi

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    Tibor Nadasdy

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Rollino, C. et al. (2017). Direct Bacterial Infection of the Renal Parenchyma: Pyelonephritis in Native Kidneys. In: Satoskar, A., Nadasdy, T. (eds) Bacterial Infections and the Kidney. Springer, Cham. https://doi.org/10.1007/978-3-319-52792-5_7

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