Skip to main content

Infection-Related Cancers in Sub-Saharan Africa

  • Chapter
  • First Online:
Cancer in Sub-Saharan Africa

Abstract

Despite the increasing effects of regional urbanisation in most of sub-Saharan Africa, infection still remains a leading cause of morbidity and mortality, and it accounts for 30% of all cancers in the region. The young are more commonly affected compared to the older age group in developed countries. Viruses are the most implicated organisms, and the prevalence of HIV in the sub-region has emerged as a major co-factor in cancer development. As most of these infections are preventable, the use of vaccines against carcinogenic infections has proven to be effective in reducing the incidence of majority of these group of cancers. Additionally, early detection and targeted intervention have significantly reduced the burden of infection-related cancers worldwide. While these programs have been successfully incorporated into the health care systems of industrialised nations, limited resources and a lack of tangible indicators of success have limited their effective implementation in sub-Saharan Africa. Measures aimed at increasing awareness of these cancers, effective progress evaluation, and policy-driven prioritisation of cancer prevention and treatment in the sub-region will effectively reduce their incidence and associated morbidity and mortality.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Allain J. Screen and treat for chronic hepatitis B: an overdue issue for sub-Saharan Africa. Lancet. 2016;4(8):e507–8.

    PubMed  Google Scholar 

  • Bayo S, Bosch FX, de Sanjose S, et al. Risk factors of invasive cervical cancer in Mali. Int J Epidemiol. 2002;31:202–9.

    Article  PubMed  Google Scholar 

  • Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the human development index (2008–2030): a population-based study. Lancet Oncol. 2012;13(8):790–801.

    Article  PubMed  Google Scholar 

  • Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132(5):1133–45.

    Article  CAS  PubMed  Google Scholar 

  • Butel J. Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease. Carcinogenesis. 2000;21(3):405–26.

    Article  CAS  PubMed  Google Scholar 

  • Cancian L, Hansen A, Boshoff C. Cellular origin of Kaposi’s sarcoma and Kaposi’s sarcoma-associated herpesvirus-induced cell reprogramming. Trends Cell Biol. 2013;23:421–32.

    Article  CAS  PubMed  Google Scholar 

  • Carpenter LM, Newton R, Casabonne D, et al. Antibodies against malaria and Epstein-Barr virus in childhood Burkitt lymphoma: a case-control study in Uganda. Int J Cancer. 2008;122(6):1319–23.

    Article  CAS  PubMed  Google Scholar 

  • Casper C. The increasing burden of HIV-associated malignancies in resource-limited regions. Annu Rev Med. 2011;62:157–70.

    Article  CAS  PubMed  Google Scholar 

  • Chene A, Donati D, Guerreiro-Cacais AO, et al. A molecular link between malaria and Epstein-Barr virus reactivation. PLoS Pathog. 2007;3(6):e80.

    Article  PubMed  PubMed Central  Google Scholar 

  • Clifford GM, Gallus S, Herrero R, et al. Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis. Lancet. 2005;366:991–8.

    Article  CAS  PubMed  Google Scholar 

  • Colley DG, Bustinduy AL, Secor WE, King CH. Human schistosomiasis. Lancet. 2014;383:2253–64.

    Article  PubMed  PubMed Central  Google Scholar 

  • de Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13(6):607–15.

    Article  PubMed  Google Scholar 

  • de-The G. Is Burkitt’s lymphoma related to perinatal infection by Epstein-Barr virus? Lancet. 1977;1(8007):335–8.

    Article  CAS  PubMed  Google Scholar 

  • Ferlay J, Shin HR, Bray F, Forman D, Mathers CD, Parkin D. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.

    Article  CAS  PubMed  Google Scholar 

  • Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.

    Article  CAS  PubMed  Google Scholar 

  • Finocchario-Kessler S, Wexler C, Maloba M, et al. Cervical cancer prevention and treatment research in Africa: a systematic review from a public health perspective. BMC Women’s Health. 2016;16(1):29.

    Google Scholar 

  • Flint JS, Enquist LW, Racaniello VR, Skalka AM, editors. Principles of virology: infection of a susceptible host. Washington, DC: American Society of Microbiology; 2009. p. 191.

    Google Scholar 

  • Fulford AJ, Ouma JH, Kimani G, Dunne DW. Puberty and age-related changes in susceptibility to schistosome infection. Parasitol Today. 1998;14(1):23–6. doi:10.1016/S0169-4758(97)01168-X.

    Article  CAS  PubMed  Google Scholar 

  • Ganem D. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J Clin Invest. 2010;120:939–49.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Halec G, Alemany L, Lloveras B, Schmitt M, Alejo M, Bosch FX, et al. Pathogenic role of the eight probably/possibly carcinogenic HPV types 26, 53, 66, 67, 68, 70, 73 and 82 in cervical cancer. J Pathol. 2014;234(4):441–51.

    Article  CAS  PubMed  Google Scholar 

  • Herrero R, Franceschi S. Vaccination. In: Stewart BW, Wild C, editors. World cancer report. Lyon: International Agency for Research on Cancer; 2014. p. 314–21.

    Google Scholar 

  • Hjalgrim H, Friborg J, Melbye M. The epidemiology of EBV and its association with malignant disease. In: CBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health, Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors. Human herpesviruses: biology, therapy, and immunoprophylaxis. Cambridge: Cambridge University Press; 2007.

    Google Scholar 

  • Howell J, Ladep NG, Lemoine M, et al. Hepatitis B in sub-Saharan Africa. S Sudan Med J. 2014;7(3):59–61.

    Google Scholar 

  • Jemal A, Bray F, Forman D, O’Brien M, Ferlay J, Center M, et al. Cancer burden in Africa and opportunities for prevention. Cancer. 2012;118(18):4372–84.

    Article  PubMed  Google Scholar 

  • Kamal SM, El Sayed Khalifa K. Immune modulation by helminthic infections: worms and viral infections. Parasite Immunol. 2006;28:483–96.

    Article  CAS  PubMed  Google Scholar 

  • Lancet Editorial. HPV vaccination: a decade on. Lancet. 2016;388(10043):438.

    Google Scholar 

  • Lemoine M, Shimakawa Y, Njie R, et al. Acceptability and feasibility of screen-and-treat program for hepatitis B virus infection in the Gambia: the prevention of liver fibrosis and cancer in Africa (PROLIFICA) study. Lancet Glob Health. 2016;4(8):e559–67.

    Article  PubMed  Google Scholar 

  • Lewis N, Young J, Hesseling PB, McCormick P, Wright N. Epidemiology of Burkitt’s lymphoma in Northwest Province, Cameroon, 2003–2010. Paediatr Int Child Health. 2012;32(2):82–5.

    Article  CAS  PubMed  Google Scholar 

  • Liao JB. Viruses and human cancer. Yale J Biol Med. 2006;79:115–22.

    CAS  PubMed  Google Scholar 

  • Mabula JB, McHembe MD, Koy M, Chalya PL, Massaga F, Rambau PF, et al. Gastric cancer at a university teaching hospital in northwestern Tanzania: a retrospective review of 232 cases. World J Surg Oncol. 2012;10:257.

    Article  PubMed  PubMed Central  Google Scholar 

  • Martin JN. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and Kaposi sarcoma. Adv Dent Res. 2011;23:76–8.

    Article  CAS  PubMed  Google Scholar 

  • Mbulaiteye SM, Bhatia K, Adebamowo C, Sasco AJ. HIV and cancer in Africa: mutual collaboration between HIV and cancer programs may provide timely research and public health data. Infect Agents Cancer. 2011;6:16.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mendy M, Peterson I, Hossin S, et al. Observational study of vaccine efficacy 24 years after the start of hepatitis B vaccination in two Gambian villages: no need for a booster dose. PLoS One. 2013;8(3):e58029.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mesri EA, Cesarman E, Boshoff C. Kaposi’s sarcoma and its associated herpesvirus. Nat Rev Cancer. 2010;10:707–19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mesri EA, Feitelson MA, Munger K. Human viral oncogenesis: a cancer hallmarks analysis. Cell Host Microbe. 2014;15:266–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Miyahara R, Jasseh M, Gomez P, et al. Barriers to timely administration of birth doses vaccines in the Gambia, West Africa. Vaccine. 2016;34(29):3335–41.

    Article  PubMed  PubMed Central  Google Scholar 

  • Molyneux EM, Rochford R, Griffin B, et al. Burkitt’s lymphoma. Lancet. 2012;379(9822):1234–44.

    Article  PubMed  Google Scholar 

  • Munoz N, Bosch FX, De Sanjosé S, Tafur L, Izarzugaza I, Gili M, et al. The causal link between human papillomavirus and invasive cervical cancer: a population-based case-control study in Colombia and Spain. Int J Cancer. 1992;52(5):743–9.

    Article  CAS  PubMed  Google Scholar 

  • Okuku F, et al. Infection-related cancers in sub-Saharan Africa: a paradigm for cancer prevention and control. Oncology. 2013;84:75–80.

    Article  PubMed  Google Scholar 

  • Palacio-Mejía LS, Range-Gomez G, Hernandez Avila M, et al. Cervical cancer, a disease of poverty: mortality difference between urban and rural areas in Mexico. Salud Publica Mex. 2003;45(Suppl 3):S315–25.

    Article  PubMed  Google Scholar 

  • Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118(12):3030–44.

    Article  CAS  PubMed  Google Scholar 

  • Parkin DM, Bray F, Ferlay J, Jemal A. Cancer in Africa 2012. Cancer Epidemiol Biomarkers Prev. 2014;23(6):953–66.

    Article  PubMed  Google Scholar 

  • Plummer M, De Martel C, Ferlay J et al. Global burden of cancers attributable to infections in 2012: a synthentic analysis. Lancet Glob Health. 2016. doi:10.1016/S2214-109X(16)30143-7.

  • Sheweita SA, El-Shahat FG, Bazeed MA, Abu El-Maati MR, O’Connor PJ. Effects of schistosoma haematobium infection on drug-metabolizing enzymes in human bladder cancer tissues. Cancer Lett. 2004;205(1):15–21.

    Article  CAS  PubMed  Google Scholar 

  • Sixbey JW, Nedrud JG, Raab-Traub N, Hanes RA, Pagano JS. Epstein-Barr virus replication in oropharyngeal epithelial cells. N Engl J Med. 1984;310(19):1225–30.

    Article  CAS  PubMed  Google Scholar 

  • Smotkin D, Prokoph H, Wettstein FO. Oncogenic and nononcogenic human genital papillomaviruses generate the E7 mRNA by different mechanisms. J Virol. 1989;63(3):1441–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Teras LR, Rollison DE, Pawlita M, Michel A, Brozy J, de Sanjose S, Blase JL, Gapstur SM. Epstein-Barr virus and risk of non-Hodgkin lymphoma in the cancer prevention study-II and a meta-analysis of serologic studies. Int J Cancer. 2015;136(1):108–16.

    Article  CAS  PubMed  Google Scholar 

  • Thompson MP, Kurzrock R. Epstein-Barr virus and cancer. Clin Cancer Res. 2004;10(3):803–21.

    Article  CAS  PubMed  Google Scholar 

  • Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12–9.

    Article  CAS  PubMed  Google Scholar 

  • WHO Global Health Observation Data Repository. 2015. http://apps.who.int/gho/data/view.main.22100?lang=en

  • Yosry A. Schistosomiasis and neoplasia. Contrib Microbiol. 2006;13:81–100.

    Article  PubMed  Google Scholar 

  • Young LS, Rickinson AB. Epstein-Barr virus: 40 years on. Nat Rev Cancer. 2004;4(10):757–68.

    Article  CAS  PubMed  Google Scholar 

  • Zucca E, Rohatiner A, Magrath I, Cavalli F. Epidemiology and management of lymphoma in low-income countries. Hematol Oncol. 2011;29(1):1–4.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Martin Nnaji MBBS, FRCS .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Nnaji, M., Adedeji, O.A., Sule, O. (2017). Infection-Related Cancers in Sub-Saharan Africa. In: Adedeji, O. (eds) Cancer in Sub-Saharan Africa. Springer, Cham. https://doi.org/10.1007/978-3-319-52554-9_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-52554-9_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52553-2

  • Online ISBN: 978-3-319-52554-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics