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Treatment of Premature Ejaculation

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The Textbook of Clinical Sexual Medicine

Abstract

Oral drug treatment for PE has been available since 1932 when Bernard Schapiro developed Präjaculin for the treatment of lifelong PE, which was even more than a decade before the first review article on PE was published by Schapiro in 1943 and long before behavioral treatments were advocated as the first choice of treatment. However, it was only after the introduction of the selective serotonin reuptake inhibitors (SSRIs) in the early 1990s that drug treatment of PE became revolutionized. Lack of an operationalized definition of PE and the absence of an objective measure of the ejaculation time hampered a truly scientific approach to investigate the efficacy of drugs in delaying ejaculation. Waldinger et al. introduced in 1994 the intravaginal ejaculation latency time (IELT) as a standardized measure of the ejaculation time. Various drugs are currently available for the treatment of PE, but all of them, except dapoxetine, are off-label. This chapter will discuss current treatments of PE with their advantages and disadvantages including daily treatment with SSRIs, on-demand treatment with oral drugs and topical anesthetics, and psychosocial treatments.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA

    Marcel D. Waldinger

  2. Private Practice in Psychiatry and Neurosexology, De Schulp 4, 1181, NA, Amstelveen, The Netherlands

    Marcel D. Waldinger

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  1. Marcel D. Waldinger
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Correspondence to Marcel D. Waldinger .

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Editors and Affiliations

  1. Cedars-Sinai Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Waguih William IsHak

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Waldinger, M.D. (2017). Treatment of Premature Ejaculation. In: IsHak, W. (eds) The Textbook of Clinical Sexual Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-52539-6_19

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  • DOI: https://doi.org/10.1007/978-3-319-52539-6_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52538-9

  • Online ISBN: 978-3-319-52539-6

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