Skip to main content

Directions for Future Research on ETAS Theory and Mental Health

  • Chapter
  • First Online:
  • 660 Accesses

Part of the book series: Religion, Spirituality and Health: A Social Scientific Approach ((RELSPHE,volume 1))

Abstract

This chapter proposes future research related to ETAS Theory’s four levels of analysis. Research at the behavioral level (Level I), particularly, psychological and sociological research, is proposed to test behavioral predictions from ETAS Theory about the association between mental health and beliefs, threats, and safety. Future Level I research should examine more beliefs and more classes of psychiatric symptoms, as well as their lifetime prevalence. The chapter notes that much more cognitive-affective neuroscience research (Level II) is needed to determine the association of many classes of psychiatric symptoms with brain structure and function, and the relationship between beliefs, brain function, and psychiatric symptoms, to test ETAS Theory predictions at this level of analysis. One section of the chapter describes the design of three experiments to test the effects of different religious beliefs on psychiatric symptoms and the activity of the ventromedial prefrontal cortex, the amygdala, and other brain structures implicated by ETAS Theory to be involved in processing beliefs and the threat assessments that underlie psychiatric symptoms. The studies contrast the effects of beliefs that should enhance or reduce the perceptions of threat. Level III involves detailed neuro-anatomical and neuro-physiological analyses to define the specific neural circuits or networks that comprise different ETAS and determine how they operate. Level IV is an evolutionary level of analysis that uses the methodology of comparative anatomy and comparative behavior to understand the evolutionary origins of psychiatric disorders as well as beliefs.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Notes

  1. 1.

    Technically, its name is the bed nucleus of the stria terminalis.

  2. 2.

    The “aversive amplification circuit” consists of the dorsomedial prefrontal cortex, anterior cingulated gyrus, and the amygdala.

References

  1. Flannelly, K.J., Galek, K., Ellison, C.G., & Koenig, H.G. (2010). Beliefs about God, psychiatric symptoms, and evolutionary psychiatry. Journal of Religion & Health, 49(2), 246–261.

    Article  Google Scholar 

  2. Silton, N.R., Flannelly, K.J., Galek, K., & Ellison, C.G. (2014). Beliefs about God and mental health among American adults. Journal of Religion and Health, 53(5), 1285–1296.

    Article  Google Scholar 

  3. Gaudette, H., & Jankowski, K.R. (2013). Spiritual coping and anxiety in palliative care patients: A pilot study. Journal of Health Care Chaplaincy, 19(4), 131–139.

    Article  Google Scholar 

  4. Gilbert, P. (1993). Defence and safety: Their function in social behaviour and psychopathology. British Journal of Clinical Psychology, 32(Pt 2), 131–153.

    Article  Google Scholar 

  5. Arndt, J., Routledge, C., Cox, C.R., & Goldenberg, J.L. (2005). The worm at the core: A terror management perspective on the roots of psychological dysfunction. Applied & Preventive Psychology, 11(3), 191.

    Article  Google Scholar 

  6. Dechesne, M., Arndt, J., Ransom, S., Sheldon, K.M., Pyszczynski, T., Van Knippenberg, A., et al. (2003). Literal and symbolic immortality: The effect of evidence of literal immortality on self-esteem striving in response to mortality salience. Journal of Personality & Social Psychology, 84(4), 722–737.

    Article  Google Scholar 

  7. Pyszczynsi, T., Greenberg, J., Solomon, S., Arndt, J., & Schimel, J. (2004). Why do people need self-esteem? A theoretical and empirical review. Psychological Bulletin, 130(3), 435–468.

    Article  Google Scholar 

  8. Martens, A., Greenberg, J., & Allen, J.J.B. (2008). Self-esteem and autonomic physiology: Parallels between self-esteem and cardiac vagal tone as buffers of threat. Personality and Social Psychology Review, 12(4), 370–389.

    Article  Google Scholar 

  9. Baldwin, M.W., & Wesley, R. (1996). Effects of existential anxiety and self-esteem on the perception of others. Basic and Applied Social Psychology, 18(1), 75–94.

    Article  Google Scholar 

  10. Karademas, E.C., Kafetsios, K., & Sideridis, G.D. (2007). Optimism, self-efficacy and information processing of threat- and well-being-related stimuli. Stress and Health, 23(5), 285–294.

    Article  Google Scholar 

  11. Gruenewald, T.L., Aziz, N., Fahey, J.L., & Kemeny, M.E. (2004). Acute threat to the social self: Shame, social self-esteem, and cortisol activity. Psychosomatic Medicine, 66(6), 915–924.

    Article  Google Scholar 

  12. Houston, B.K., Olson, M., & Botkin, A. (1972). Trait anxiety and beliefs regarding danger and threat to self-esteem. Journal of Consulting and Clinical Psychology, 38(1), 152.

    Article  Google Scholar 

  13. van Dellen, M.R., Campbell, W.K., Hoyle, R.H., & Bradfield, E.K. (2001). Compensating, resisting, and breaking: A meta-analytic examination of reactions to self-esteem threat. Personality and Social Psychology Review, 15(1), 51–74.

    Google Scholar 

  14. Leary, M.R., Barnes, B.D., & Griebel, C. (1986). Cognitive, affective, and attributional effects of potential threats to self-esteem. Journal of Social & Clinical Psychology, 4(4), 461.

    Article  Google Scholar 

  15. Elllison, C.G., Flannelly, K.J., & Barrie, C.K. (2014, November 1). Do afterlife beliefs moderate the association between recent serious illness and symptoms of anxiety-related disorders? Paper presented at the National Meeting of the Society for the Scientific Study of Religion, Indianapolis, IN.

    Google Scholar 

  16. Nesse, R. (1998). Emotional disorders in evolutionary perspective. British Journal of Medical Psychology, 71(4), 397–415.

    Article  Google Scholar 

  17. Nesse, R.M. (1984). An evolutionary perspective on psychiatry. Comprehensive Psychiatry, 25(6), 575–580.

    Article  Google Scholar 

  18. Nesse, R.M. (1987). An evolutionary perspective on panic disorder and agoraphobia. Ethology & Sociobiology, 8, 73S–83S.

    Article  Google Scholar 

  19. Nesse, R.M. (1990). Evolutionary explanations of emotions. Human Nature, 1(3), 261–289.

    Article  Google Scholar 

  20. Grillon, C. (2008). Models and mechanisms of anxiety: Evidence from startle studies. Psychopharmacology, 199(3), 421–437.

    Article  Google Scholar 

  21. Walker, D.L., Toufexis, D.J., & Davis, M. (2003). Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. European Journal of Pharmacology, 463(1), 199–216.

    Article  Google Scholar 

  22. Munsterkotter, A.L., Notzon, S., Redlich, R., Grotegerd, D., Dohm, K., Arolt, V., et al. (2015). Spider or no spider? Neural correlates of sustained and phasic fear in spider phobia. Depression and Anxiety, 32(9), 656–663.

    Article  Google Scholar 

  23. Robinson, O.J., Krimsky, M., Lieberman, L., Allen, P., Vytal, K., & Grillon, C. (2014). Towards a mechanistic understanding of pathological anxiety: The dorsal medial prefrontal-amygdala “aversive amplification” circuit in unmedicated generalized and social anxiety disorders. The Lancet. Psychiatry, 1(4), 294.

    Article  Google Scholar 

  24. Ochsner, K.N., Bunge, S.A., Gross, J.J., & Gabrieli, J.D. (2002). Rethinking feelings: An fMRI study of the cognitive regulation of emotion. Journal of Cognitive Neuroscience, 14(8), 1215–1229.

    Article  Google Scholar 

  25. Ochsner, K.N., & Gross, J.J. (2005). The cognitive control of emotion. Trends in Cognitive Science, 9(5), 242–249.

    Article  Google Scholar 

  26. Ochsner, K.N., Knierim, K., Ludlow, D.H., Hanelin, J., Ramachandran, T., Glover, G., et al. (2004). Reflecting upon feelings: An fMRI study of neural systems supporting the attribution of emotion to self and other. Journal of Cognitive Neuroscience, 16(10), 1746–1772.

    Article  Google Scholar 

  27. Ochsner, K.N., Ray, R.D., Cooper, J.C., Robertson, E.R., Chopra, S., Gabrieli, J.D., et al. (2004). For better or for worse: Neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage, 23(2), 483–499.

    Article  Google Scholar 

  28. Greenberg, T., Carlson, J.M., Cha, J., Hajcak, G., & Mujica-Parodi, L.R. (2013). Ventromedial prefrontal cortex reactivity is altered in generalized anxiety disorder during fear generalization. Depression and Anxiety, 30(3), 242–250.

    Article  Google Scholar 

  29. Motzkin, J.C., Philippi, C.L., Wolf, R.C., Koenigs, M., & Baskaya, M.K. (2015). Ventromedial prefrontal cortex is critical for the regulation of amygdala activity in humans. Biological Psychiatry, 77(3), 276–284.

    Article  Google Scholar 

  30. Magee, W.J., Eaton, W.W., Wittchen, H.U., McGonagle, K.A., & Kessler, R.C. (1996). Agoraphobia, simple phobia, and social phobia in the national comorbidity survey. Archives of General Psychiatry, 53, 159–168.

    Article  Google Scholar 

  31. Kessler, R.C., McGonagle, K.A., Zhao, S., Nelson, C.B., Hughes, M., Eshleman, S., et al. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: Results from the National Comorbidity Study. Archives of General Psychiatry, 51(1), 8–19.

    Article  Google Scholar 

  32. Yang, J., Xu, X., Chen, Y., Shi, Z., & Han, S. (2016). Trait self-esteem and neural activities related to self-evaluation and social feedback. Scientific Reports, 6. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740758/pdf/srep20274.pdf

  33. Pan, W., Liu, C., Yang, Q., Gu, Y., Yin, S., & Chen, A. (2016). The neural basis of trait self-esteem revealed by the amplitude of low-frequency fluctuations and resting state functional connectivity. Social Cognitive and Affective Neuroscience, nsv119. Retrieved from http://scan.oxfordjournals.org/content/11/3/367.short

  34. Mulders, P.C., van Eijndhoven, P.F., Schene, A.H., Beckmann, C.F., & Tendolkar, I. (2015). Resting-state functional connectivity in major depressive disorder: A review. Neuroscience & Biobehavioral Reviews, 56, 330–344.

    Article  Google Scholar 

  35. Mochcovitch, M.D., da Rocha Freire, R.C., Garcia, R.F., & Nardi, A.E. (2014). A systematic review of fMRI studies in generalized anxiety disorder: Evaluating its neural and cognitive basis. Journal of Affective Disorders, 167, 336–342.

    Article  Google Scholar 

  36. Hilbert, K., Lueken, U., & Beesdo-Baum, K. (2014). Neural structures, functioning and connectivity in Generalized Anxiety Disorder and interaction with neuroendocrine systems: A systematic review. Journal of Affective Disorders, 158, 114–126.

    Article  Google Scholar 

  37. Bruhl, A.B., Delsignore, A., Komossa, K., & Weidt, S. (2014). Neuroimaging in social anxiety disorder – A meta-analytic review resulting in a new neurofunctional model. Neuroscience & Biobehavioral Reviews, 47, 260–280.

    Article  Google Scholar 

  38. Jang, J.H., Kim, J.-H., Jung, W.H., Choi, J.-S., Jung, M.H., Lee, J.-M., et al. (2010). Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder. Neuroscience Letters, 474(3), 158–162.

    Article  Google Scholar 

  39. Harrison, B.J., Soriano-Mas, C., Pujol, J., Ortiz, H., Lopez-Sola, M., Hernández-Ribas, R., et al. (2009). Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Archives of General Psychiatry, 66(11), 1189–1200.

    Article  Google Scholar 

  40. Kasper, S., Gryglewski, G., & Lanzenberger, R. (2014). Imaging brain circuits in anxiety disorders. The Lancet Psychiatry, 1(4), 251–252.

    Article  Google Scholar 

  41. Fiala, A., Suska, A., & Schluter, O.M. (2010). Optogenetic approaches in neuroscience. Current Biology, 20(20), R897-R903.

    Article  Google Scholar 

  42. Kravitz, A.V., & Kreitzer, A.C. (2011). Optogenetic manipulation of neural circuitry in vivo. Current Opinion in Neurobiology, 21(3), 433–439.

    Article  Google Scholar 

  43. Johansen, J.P., Wolff, S.B.E., Luthi, A., & LeDoux, J.E. (2012). Controlling the elements: An optogenetic approach to understanding the neural circuits of fear. Biological Psychiatry, 71(12), 1053–1060.

    Article  Google Scholar 

  44. LeDoux, J.E. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23(1), 155–184.

    Article  Google Scholar 

  45. Gold, J.I., & Shadlen, M.N. (2007). The neural basis of decision making. Annual Review of Neuroscience, 30, 535–574.

    Article  Google Scholar 

  46. Gold, J.I., & Shadlen, M.N. (2001). Neural computations that underlie decisions about sensory stimuli. Trends in Cognitive Sciences, 5(1), 10–16.

    Article  Google Scholar 

  47. Averbeck, B.B., & Lee, D. (2004). Coding and transmission of information by neural ensembles. Trends in Neuroscience, 27(4), 225–230.

    Article  Google Scholar 

  48. Winecoff, A., Clithero, J.A., Carter, R.M., Bergman, S.R., Wang, L.H., & Huettel, S.A. (2013). Ventromedial prefrontal cortex encodes emotional value. Journal of Neuroscience, 33(27), 11032–11039.

    Article  Google Scholar 

  49. Fellous, J.-M., Armony, J.L., & LeDoux, J.E. (2002). Emotional circuits and computational neuroscience. In M.A. Arbib (Ed.), The handbook of brain theory and neural networks. 2nd ed.). Cambridge, MA: MIT press.

    Google Scholar 

  50. LeDoux, J.E. (1995). Emotion: Clues from the brain. Annual Review of Psychology, 46, 209–235.

    Article  Google Scholar 

  51. Phelps, E. A., & LeDoux, J. E. (2005). Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron, 48, 175–187.

    Article  Google Scholar 

  52. Blanchard, D.C., Griebel, G., & Blanchard, R.J. (2001). Mouse defensive behaviors: Pharamacological and behavioral assays for anxiety and panic. Neuroscience and Behavioral Reviews, 25, 205–218.

    Article  Google Scholar 

  53. Blanchard, D.C., Griebel, G., & Blanchard, R.J. (2003). The mouse defense test battery: Pharmacological and behavioral assays for anxiety and panic. European Journal of Pharmacology, 463(1), 97–116.

    Article  Google Scholar 

  54. Blanchard, R.J., Flannelly, K.J., & Blanchard, D.C. (1986). Defensive behaviors of laboratory and wild Rattus norvegicus. Journal of Comparative Psychology, 100(2), 101–107.

    Article  Google Scholar 

  55. Flannelly, K., & Lore, R. (1977). The influence of females upon aggression in domesticated male rats (Rattus norvegicus). Animal Behaviour, 25, 654–659.

    Article  Google Scholar 

  56. Flannelly, K.J., & Thor, D.H. (1978). Territorial aggression of the rat to males castrated at various ages. Physiology & Behavior, 20(6), 785–789.

    Article  Google Scholar 

  57. Blanchard, R.J., Kleinschmidt, C.K., Flannelly, K.J., & Blanchard, D.C. (1984). Fear and aggression in the rat. Aggressive Behavior, 10(4), 309–315.

    Article  Google Scholar 

  58. Blanchard, D.C., Williams, G., Lee, E.M.C., & Blanchard, R.J. (1981). Taming of wild Rattus norvegicus by lesions of the mesencephalic central gray. Physiological Psychology, 9(2), 157–163.

    Article  Google Scholar 

  59. Grant, E.C., & Mackintosh, J.H. (1963). A comparison of the social postures of some common laboratory rodents. Behaviour, 21(3), 246–259.

    Article  Google Scholar 

  60. Liu, C., & Cerny, V. (1976). Release of grooming responses in basal ganglia and thalamic cats. Anatomical Record, 184(3), 464.

    Google Scholar 

  61. Strazielle, C., Lefevre, A., Jacquelin, C., & Lalonde, R. (2012). Abnormal grooming activity in Dab1 scm (scrambler) mutant mice. Behavioural Brain Research, 233(1), 24–28.

    Article  Google Scholar 

  62. Cromwell, H.C., & Berridge, K.C. (1996). Implementation of action sequences by a neostriatal site: A lesion mapping study of grooming syntax. Journal of Neuroscience, 16(10), 3444–3458.

    Google Scholar 

  63. Thompson, R., Huestis, P.W., Shea, C.N., Crinella, F.M., & Yu, Y. (1990). Brain structures important for solving a sawdust-digging problem in the rat. Physiology & Behavior, 48(1), 107–111.

    Article  Google Scholar 

  64. Aldridge, J.W., Berridge, K.C., & Rosen, A.R. (2004). Basal ganglia neural mechanisms of natural movement sequences. Canadian Journal of Physiological Pharmacology, 82, 732–739.

    Article  Google Scholar 

  65. Langen, M., Durston, S., Kas, M.J.H., van Engeland, H., & Staal, W.G. (2010). The neurobiology of repetitive behavior: And men. Neuroscience & Biobehavioral Reviews, 35(3), 356–365.

    Article  Google Scholar 

  66. Langen, M., Kas, M.J.H., Staal, W.G., van Engeland, H., & Durston, S. (2010). The neurobiology of repetitive behavior: Of mice. Neuroscience & Biobehavioral Reviews, 35(3), 345–355.

    Article  Google Scholar 

  67. Baxter Jr, L.R., Clark, E.C., Ackermann, R.F., Lacan, G., & Melega, W.P. (2001). Brain mediation of Anolis social dominance displays. Brain, Behavior and Evolution, 57(4), 184–201.

    Article  Google Scholar 

  68. Baxter, L.R. (2003). Basal ganglia systems in ritualistic social displays: Reptiles and humans; function and illness. Physiology & Behavior, 79, 451–460.

    Article  Google Scholar 

  69. Baxter, L.R., Jr., Ackermann, R.F., Clark, E.C., & Baxter, J.E. (2001). Brain mediation of Anolis social dominance displays. I. Differential basal ganglia activation. Brain, Behavior and Evolution, 57(4), 169–183.

    Article  Google Scholar 

  70. MacLean, P.D. (1977). The Triune brain in conflict. Psychotherapy and Psychosomatics, 28, 207–220.

    Article  Google Scholar 

  71. Baxter Jr, L.R. (2001). Brain mediation of Anolis social dominance displays: III. Differential forebrain (3) H-sumatriptan binding to dominant vs. submissive males. Brain, Behavior and Evolution, 57(4), 202–213.

    Article  Google Scholar 

  72. Gorlick, D.L. (1990). Neural pathway for aggressive display in Betta splendens: Midbrain and hindbrain control of gill-cover erection display. Brain, Behavior and Evolution, 36(4), 227–236.

    Article  Google Scholar 

  73. Winberg, S., & Nilsson, G.E. (1993). Roles of brain monoamine neurotransmitters in agonistic behaviour and stress reactions, with particular reference to fish. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 106(3), 597–614.

    Google Scholar 

  74. Winberg, S., Myrberg Jr, A.A., & Nilsson, G.E. (1996). Agonistic interactions affect brain serotonergic activity in an acanthopterygiian fish: The bicolor damselfish (Pomacentrus partitus). Brain, Behavior and Evolution, 48(4), 213–220.

    Article  Google Scholar 

  75. Anderson, J.J. (1988). A neural model for visual activation of startle behavior in fish. Journal of Theoretical Biology, 131(3), 279–288.

    Article  Google Scholar 

  76. Yasargil, G.M., & Diamond, J. (1968). Startle-response in teleost fish: An elementary circuit for neural discrimination. Nature, 220(October 18), 241–243.

    Article  Google Scholar 

  77. Goodson, J.L. (2005). The vertebrate social behavior network: Evolutionary themes and variations. Hormones and Behavior, 48(1), 11–22.

    Article  Google Scholar 

  78. Maximino, C., Lima, M.G., Oliveira, K.R.M., de Batista, E.J.O., & Herculano, A.M. (2013). “Limbic associative” and “autonomic” amygdala in teleosts: A review of the evidence. Journal of Chemical Neuroanatomy, 48, 1–13.

    Article  Google Scholar 

  79. Martin, A., & Santos, L.R. (2014). The origins of belief representation: Monkeys fail to automatically represent others’ beliefs. Cognition, 130(3), 300–308.

    Article  Google Scholar 

  80. Povinelli, D.J., & Giambrone, S. (2001). Reasoning about beliefs: A human specialization? Child Development, 72(3), 691–695.

    Article  Google Scholar 

  81. Wolpert, L. (2007). Six impossible things before breakfast: The evolutionary origins of beliefs. New York: W.W. Norton & Co.

    Google Scholar 

  82. Flannelly, K.J. (2008). Review of the book Six impossible things before breakfast: The evolutionary origins of beliefs by L. Wolpert. Journal of Nervous & Mental Disease, 196(7), 581–582.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Flannelly, K.J. (2017). Directions for Future Research on ETAS Theory and Mental Health. In: Religious Beliefs, Evolutionary Psychiatry, and Mental Health in America. Religion, Spirituality and Health: A Social Scientific Approach, vol 1. Springer, Cham. https://doi.org/10.1007/978-3-319-52488-7_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-52488-7_31

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52487-0

  • Online ISBN: 978-3-319-52488-7

  • eBook Packages: Social SciencesSocial Sciences (R0)

Publish with us

Policies and ethics