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The Utility of Multiplex Assays for Identification of Proteomic Signatures in Psychiatry

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Proteomic Methods in Neuropsychiatric Research

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 974))

Abstract

As substantial efforts are being made to identify biological markers of psychiatric illnesses, it is becoming clear that clinically useful accuracy will require larger sets of readouts that potentially span different technological platforms. For discovery of proteomic biomarkers, simultaneous measurement of analytes in small sample quantities has developed into a widely used technology of similar quality as the respective single-plex assays. Multiplex assay systems therefore hold promise for biomarker discovery and development in many complex disease areas including psychiatry. However, analysis of the derived data is subject to substantial challenges that may impede the possibility of obtaining meaningful findings. This chapter discusses potential applications of multiplexed assay technologies during biomarker development and highlights potential challenges for machine learning analysis of derived data.

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Acknowledgments

This study was supported by the DFG Emmy-Noether-Program SCHW 1768/1-1.

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

    Junfang Chen & Emanuel Schwarz

  2. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Rua Monteiro Lobato 255 F/01, Cidade Universitária Zeferino Vaz, 13083-862, Campinas, Brazil

    Paul C. Guest

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  1. Junfang Chen
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  2. Paul C. Guest
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  3. Emanuel Schwarz
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Correspondence to Emanuel Schwarz .

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Editors and Affiliations

  1. Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Chen, J., Guest, P.C., Schwarz, E. (2017). The Utility of Multiplex Assays for Identification of Proteomic Signatures in Psychiatry. In: Guest, P. (eds) Proteomic Methods in Neuropsychiatric Research. Advances in Experimental Medicine and Biology(), vol 974. Springer, Cham. https://doi.org/10.1007/978-3-319-52479-5_8

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