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MIF Family Cytokines in Innate Immunity and Homeostasis pp 175–187Cite as

The MIF-CD74 Inflammatory Axis in Alphaviral Infection

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The expansion of mosquito-borne viral (arboviral) arthritis poses a significant threat to human health worldwide. Clinical reports show that arboviral arthritis can be persistent and debilitating, with evidence of bone pathology. As part of the Togaviridae family, alphaviruses are mosquito-borne viruses that are widely distributed throughout the globe causing extensive morbidity and mortality. Despite this, very little is known about the pathogenesis of disease caused by alphaviruses. It has been shown that macrophages play a crucial role in the development of alphaviral arthritis. Infection causes macrophage activation and the release of macrophage inhibitory factor (MIF), which subsequently plays a pivotal role in alphavirus-induced arthritis by regulating the expression of pro-inflammatory factors. This chapter discusses the role of the MIF-CD74 axis in the development of alphavirus arthritis and the therapeutic potential of antagonists in the treatment of alphaviral arthropathies.

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Author information

Authors and Affiliations

  1. Emerging Virus and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, QLD, 4222, Australia

    Lara J. Herrero, Ali Zaid, Margit Mutso & Suresh Mahalingam Ph.D.

Authors
  1. Lara J. Herrero
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  2. Ali Zaid
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  3. Margit Mutso
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  4. Suresh Mahalingam Ph.D.
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Corresponding author

Correspondence to Suresh Mahalingam Ph.D. .

Editor information

Editors and Affiliations

  1. The Anlyan Center, Yale School of Medicine, Yale University, New Haven, Connecticut, USA

    Richard Bucala

  2. Department of Vascular Biology, Institute for Stroke and Dementia Research, Ludwig-Maximilians-University (LMU), Munich, Germany

    Jürgen Bernhagen

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Herrero, L.J., Zaid, A., Mutso, M., Mahalingam, S. (2017). The MIF-CD74 Inflammatory Axis in Alphaviral Infection. In: Bucala, R., Bernhagen, J. (eds) MIF Family Cytokines in Innate Immunity and Homeostasis. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-52354-5_11

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  • DOI: https://doi.org/10.1007/978-3-319-52354-5_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52352-1

  • Online ISBN: 978-3-319-52354-5

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