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MIF- and CD74-Dependent Mechanisms

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MIF Family Cytokines in Innate Immunity and Homeostasis

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

CD74 is a type II cell surface protein that was previously shown to play a role in antigen presentation and as a receptor for the cytokine macrophage migration inhibitory factor (MIF). Studies from recent years demonstrate an important role for CD74 in maintenance of innate and adaptive immune cells. This chapter discusses the MIF/CD74-dependent role in regulating cell survival, metabolism, adhesion, and response to hypoxia in health and disease.

This chapter discusses MIF’s receptor CD74 and their central position in linking innate and adaptive immune response in health and disease.

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Authors and Affiliations

  1. Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel

    Shirly Becker-Herman, Naama Gil, Lihi Radomir & Idit Shachar Ph.D.

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  1. Shirly Becker-Herman
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  2. Naama Gil
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  3. Lihi Radomir
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  4. Idit Shachar Ph.D.
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Correspondence to Idit Shachar Ph.D. .

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  1. The Anlyan Center, Yale School of Medicine, Yale University, New Haven, Connecticut, USA

    Richard Bucala

  2. Department of Vascular Biology, Institute for Stroke and Dementia Research, Ludwig-Maximilians-University (LMU), Munich, Germany

    Jürgen Bernhagen

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Becker-Herman, S., Gil, N., Radomir, L., Shachar, I. (2017). MIF- and CD74-Dependent Mechanisms. In: Bucala, R., Bernhagen, J. (eds) MIF Family Cytokines in Innate Immunity and Homeostasis. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-52354-5_1

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