Skip to main content
SpringerLink
Log in
Book cover

Fertility Preservation and Restoration for Patients with Complex Medical Conditions pp 181–196Cite as

Chronic Kidney Disease

  • Chapter
  • First Online:

  • 554 Accesses

Abstract

There are many causes of chronic kidney disease. The end stage renal disease (ESRD) severely affects quality of life especially during the time patients need to go into dialyses. When young patients are affected by renal disease, their fertility is impaired because of physiologic changes, and usually fertility is recovered after kidney transplantation. This chapter reviews different causes of kidney failure, physiology and physiopathology of the kidney, risk factors, diagnosis techniques, and different kinds of treatments giving special importance to this section taking in account that some of these treatments have an important role on the impaired fertility that affects these patients.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Inker LA, Astor BC, Fox CH, Isakova T, Lash JP, Peralta CA, et al. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. Am J Kidney Dis Off J Nat Kidney Found. 2014;63(5):713–35.

    Article  Google Scholar 

  2. Piccoli GB, Cabiddu G, Attini R, Vigotti F, Fassio F, Rolfo A, et al. Pregnancy in chronic kidney disease: questions and answers in a changing panorama. Best Pract Res Clin Obstet Gynaecol. 2015;29(5):625–42.

    Article  PubMed  Google Scholar 

  3. Sherwood M, McCullough PA. Chronic kidney disease from screening, detection, and awareness, to prevention. Lancet Glob Health. 2016;4(5):e288–e9.

    Article  PubMed  Google Scholar 

  4. Himmelfarb J, Sayegh MHS. Chronic kidney disease: definition, epidemiology, cost, and outcomes. In: Chandraker A, Mehrotra R, O’Hare AM, Stivelman JC, Tuttle KR, Vella JP, et al., editors. Chronic kidney disease, dialysis, and transplantation. 3rd ed. Philadelphia: ELSEVIER; 2010.

    Google Scholar 

  5. Davison JM, Lindheimer MD. Pregnancy and chronic kidney disease. Semin Nephrol. 2011;31(1):86–99.

    Article  CAS  PubMed  Google Scholar 

  6. Tong A, Brown MA, Winkelmayer WC, Craig JC, Jesudason S. Perspectives on pregnancy in women with CKD: a semistructured interview study. Am J Kidney Dis Off J Nat Kidney Found. 2015;66(6):951–61.

    Article  Google Scholar 

  7. Holley JL, Schmidt RJ. Changes in fertility and hormone replacement therapy in kidney disease. Adv Chronic Kidney Dis. 2013;20(3):240–5.

    Article  PubMed  Google Scholar 

  8. McKay DB, Josephson MA. Pregnancy in recipients of solid organs--effects on mother and child. N Engl J Med. 2006;354(12):1281–93.

    Article  CAS  PubMed  Google Scholar 

  9. Williams D, Davison J. Chronic kidney disease in pregnancy. BMJ (Clin Res Ed). 2008;336(7637):211–5.

    Article  Google Scholar 

  10. Josephson MA, McKay DB. Women and transplantation: fertility, sexuality, pregnancy, contraception. Adv Chronic Kidney Dis. 2013;20(5):433–40.

    Article  PubMed  Google Scholar 

  11. Chakhtoura Z, Meunier M, Caby J, Mercadal L, Arzouk N, Barrou B, et al. Gynecologic follow up of 129 women on dialysis and after kidney transplantation: a retrospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2015;187:1–5.

    Article  PubMed  Google Scholar 

  12. Lim VS, Henriquez C, Sievertsen G, Frohman LA. Ovarian function in chronic renal failure: evidence suggesting hypothalamic anovulation. Ann Intern Med. 1980;93(1):21–7.

    Article  CAS  PubMed  Google Scholar 

  13. Lim VS, Kathpalia SC, Frohman LA. Hyperprolactinemia and impaired pituitary response to suppression and stimulation in chronic renal failure: reversal after transplantation. J Clin Endocrinol Metab. 1979;48(1):101–7.

    Article  CAS  PubMed  Google Scholar 

  14. Matuszkiewicz-Rowinska J, Skorzewska K, Radowicki S, Niemczyk S, Sokalski A, Przedlacki J, et al. Endometrial morphology and pituitary-gonadal axis dysfunction in women of reproductive age undergoing chronic haemodialysis--a multicentre study. Nephrol Dial Transplant Off Pub Eur Dial Transplant Assoc Eur Ren Assoc. 2004;19(8):2074–7.

    Google Scholar 

  15. Holley JL, Reddy SS. Pregnancy and CKD: lessons on communication from patients. Am J Kidney Dis Off J Nat Kidney Found. 2015;66(6):936–8.

    Article  Google Scholar 

  16. Framarino Dei Malatesta M, Rossi M, Rocca B, Iappelli M, Poli L, Piccioni MG, et al. Fertility following solid organ transplantation. Transplant Proc. 2007;39(6):2001–4.

    Article  CAS  PubMed  Google Scholar 

  17. Hladunewich M, Schatell D. Intensive dialysis and pregnancy: Hemodial Int. 2016;20(3):337–494, E1–E18.

    Google Scholar 

  18. Lopez LF, Martinez CJ, Castaneda DA, Hernandez AC, Perez HC, Lozano E. Pregnancy and kidney transplantation, triple hazard? Current concepts and algorithm for approach of preconception and perinatal care of the patient with kidney transplantation. Transplant Proc. 2014;46(9):3027–31.

    Article  CAS  PubMed  Google Scholar 

  19. ter Haar-van Eck SA, Rischen-Vos J, Chadha-Ajwani S, Huikeshoven FJ. The incidence of cervical intraepithelial neoplasia among women with renal transplant in relation to cyclosporine. Br J Obstet Gynaecol. 1995;102(1):58–61.

    Article  PubMed  Google Scholar 

  20. Brunner FP, Landais P, Selwood NH. Malignancies after renal transplantation: the EDTA-ERA registry experience. European Dialysis and Transplantation Association-European Renal Association. Nephrol Dial Transplant Off Publ Eur Dial Transplant Assoc Eur Ren Assoc. 1995;10 Suppl 1:74–80.

    CAS  Google Scholar 

  21. Filocamo MT, Zanazzi M, Li Marzi V, Lombardi G, Del Popolo G, Mancini G, et al. Sexual dysfunction in women during dialysis and after renal transplantation. J Sex Med. 2009;6(11):3125–31.

    Article  PubMed  Google Scholar 

  22. Pietrzak B, Wielgos M, Kaminski P, Jabiry-Zieniewicz Z, Bobrowska K. Menstrual cycle and sex hormone profile in kidney-transplanted women. Neuro Endocrinol Lett. 2006;27(1–2):198–202.

    CAS  PubMed  Google Scholar 

  23. Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis Off J Nat Kidney Found. 1998;32(5 Suppl 3):S112–9.

    Article  CAS  Google Scholar 

  24. Kim JH, Chun CJ, Kang CM, Kwak JY. Kidney transplantation and menstrual changes. Transplant Proc. 1998;30(7):3057–9.

    Article  CAS  PubMed  Google Scholar 

  25. Cochrane R, Regan L. Undetected gynaecological disorders in women with renal disease. Hum Reprod (Oxford, England). 1997;12(4):667–70.

    Article  CAS  Google Scholar 

  26. Cigni A, Faedda R, Atzeni MM, Pileri PV, Alagna S, Rovasio P, et al. Hormonal strategies for fertility preservation in patients receiving cyclophosphamide to treat glomerulonephritis: a nonrandomized trial and review of the literature. Am J Kidney Dis Off J Nat Kidney Found. 2008;52(5):887–96.

    Article  CAS  Google Scholar 

  27. Howell SJ, Shalet SM. Testicular function following chemotherapy. Hum Reprod Update. 2001;7(4):363–9.

    Article  CAS  PubMed  Google Scholar 

  28. Raptopoulou A, Sidiropoulos P, Boumpas D. Ovarian failure and strategies for fertility preservation in patients with systemic lupus erythematosus. Lupus. 2004;13(12):887–90.

    Article  PubMed  Google Scholar 

  29. Blumenfeld Z, Avivi I, Linn S, Epelbaum R, Ben-Shahar M, Haim N. Prevention of irreversible chemotherapy-induced ovarian damage in young women with lymphoma by a gonadotrophin-releasing hormone agonist in parallel to chemotherapy. Hum Reprod (Oxford, England). 1996;11(8):1620–6.

    Article  CAS  Google Scholar 

  30. Kreuser ED, Klingmuller D, Thiel E. The role of LHRH-analogues in protecting gonadal functions during chemotherapy and irradiation. Eur Urol. 1993;23(1):157–63. discussion 63-4

    CAS  PubMed  Google Scholar 

  31. Pendse S, Ginsburg E, Singh AK. Strategies for preservation of ovarian and testicular function after immunosuppression. Am J Kidney Dis Off J Nat Kidney Found. 2004;43(5):772–81.

    Article  Google Scholar 

  32. Somers EC, Marder W, Christman GM, Ognenovski V, McCune WJ. Use of a gonadotropin-releasing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus. Arthritis Rheum. 2005;52(9):2761–7.

    Article  CAS  PubMed  Google Scholar 

  33. Delesalle AS, Robin G, Provot F, Dewailly D, Leroy-Billiard M, Peigne M. Impact of end-stage renal disease and kidney transplantation on the reproductive system. Gynecol Obstet Fertil. 2015;43(1):33–40.

    Article  PubMed  Google Scholar 

  34. Kyrieleis HA, Levtchenko EN, Wetzels JF. Long-term outcome after cyclophosphamide treatment in children with steroid-dependent and frequently relapsing minimal change nephrotic syndrome. Am J Kidney Dis Off J Nat Kidney Found. 2007;49(5):592–7.

    Article  CAS  Google Scholar 

  35. White RH. Cytotoxic drug therapy in steroid-resistant glomerulonephritis. Proc R Soc Med. 1967;60(11 Part 1):1164–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Gajjar R, Miller SD, Meyers KE, Ginsberg JP. Fertility preservation in patients receiving cyclophosphamide therapy for renal disease. Pediatr Nephrol (Berlin, Germany). 2015;30(7):1099–106.

    Article  Google Scholar 

  37. Emadi A, Jones RJ, Brodsky RA. Cyclophosphamide and cancer: golden anniversary. Nat Rev Clin Oncol. 2009;6(11):638–47.

    Article  CAS  PubMed  Google Scholar 

  38. Boumpas DT, Austin 3rd HA, Vaughan EM, Yarboro CH, Klippel JH, Balow JE. Risk for sustained amenorrhea in patients with systemic lupus erythematosus receiving intermittent pulse cyclophosphamide therapy. Ann Intern Med. 1993;119(5):366–9.

    Article  CAS  PubMed  Google Scholar 

  39. Pravitsitthikul N, Willis NS, Hodson EM, Craig JC. Non-corticosteroid immunosuppressive medications for steroid-sensitive nephrotic syndrome in children. Cochrane Database Syst Rev. 2013;10:Cd002290.

    Google Scholar 

  40. Vaz-Carneiro A, Costa J. Analysis of the cochrane review: electronic cigarettes for smoking cessation and reduction. Cochrane Database Syst Rev. 2014,12: CD010216. Acta Med Port. 2015;28(2):145–7.

    Article  PubMed  Google Scholar 

  41. Hahn BH, McMahon MA, Wilkinson A, Wallace WD, Daikh DI, Fitzgerald JD, et al. American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis. Arthritis Care Res. 2012;64(6):797–808.

    Article  Google Scholar 

  42. Meistrich ML, Wilson G, Brown BW, da Cunha MF, Lipshultz LI. Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for Ewing and soft tissue sarcomas. Cancer. 1992;70(11):2703–12.

    Article  CAS  PubMed  Google Scholar 

  43. Ethics Committee of the American Society for Reproductive. Medicine Fertility preservation and reproduction in cancer patients. Fertil Steril. 2005;83(6):1622–8.

    Article  Google Scholar 

  44. Miller SD, Ginsberg JP, Caplan A, Meyers KE. Sperm banking in adolescent males with nephrotic syndrome: defining the limits of access to fertility preservation. Arch Dis Child. 2012;97(9):765–6.

    Article  PubMed  Google Scholar 

  45. Hodson EM, Willis NS, Craig JC. Interventions for idiopathic steroid-resistant nephrotic syndrome in children. Cochrane Database Syst Rev. 2010;11:cd003594.

    Google Scholar 

  46. Latta K, von Schnakenburg C, Ehrich JH. A meta-analysis of cytotoxic treatment for frequently relapsing nephrotic syndrome in children. Pediatr Nephrol (Berlin, Germany). 2001;16(3):271–82.

    Article  CAS  Google Scholar 

  47. Patrizio P, Butts S, Caplan A. Ovarian tissue preservation and future fertility: emerging technologies and ethical considerations. J Natl Cancer Inst Monogr. 2005;34:107–10.

    Article  Google Scholar 

  48. Ginsberg JP, Ogle SK, Tuchman LK, Carlson CA, Reilly MM, Hobbie WL, et al. Sperm banking for adolescent and young adult cancer patients: sperm quality, patient, and parent perspectives. Pediatr Blood Cancer. 2008;50(3):594–8.

    Article  PubMed  Google Scholar 

  49. Wyns C, Curaba M, Vanabelle B, Van Langendonckt A, Donnez J. Options for fertility preservation in prepubertal boys. Hum Reprod Update. 2010;16(3):312–28.

    Article  PubMed  Google Scholar 

  50. Diemont WL, Vruggink PA, Meuleman EJ, Doesburg WH, Lemmens WA, Berden JH. Sexual dysfunction after renal replacement therapy. Am J Kidney Dis Off J Nat Kidney Found. 2000;35(5):845–51.

    Article  CAS  Google Scholar 

  51. Raiz L, Davies EA, Ferguson RM. Sexual functioning following renal transplantation. Health Soc Work. 2003;28(4):264–72.

    Article  PubMed  Google Scholar 

  52. Muehrer RJ. Sexuality, an important component of the quality of life of the kidney transplant recipient. Transplant Rev (Orlando). 2009;23(4):214–23.

    Article  Google Scholar 

  53. Basok EK, Atsu N, Rifaioglu MM, Kantarci G, Yildirim A, Tokuc R. Assessment of female sexual function and quality of life in predialysis, peritoneal dialysis, hemodialysis, and renal transplant patients. Int Urol Nephrol. 2009;41(3):473–81.

    Article  PubMed  Google Scholar 

  54. Navaneethan SD, Vecchio M, Johnson DW, Saglimbene V, Graziano G, Pellegrini F, et al. Prevalence and correlates of self-reported sexual dysfunction in CKD: a meta-analysis of observational studies. Am J Kidney Dis Off J Nat Kidney Found. 2010;56(4):670–85.

    Article  Google Scholar 

  55. Noohi S, Azar M, Behzadi AH, Barbati ME, Haghshenas A, Amoozgar B, et al. Comparison of sexual function in females receiving haemodialysis and after renal transplantation. J Ren Care. 2010;36(4):212–7.

    Article  PubMed  Google Scholar 

  56. Hirshfeld-Cytron J, Gracia C, Woodruff TK. Nonmalignant diseases and treatments associated with primary ovarian failure: an expanded role for fertility preservation. J Womens Health (Larchmt). 2011;20(10):1467–77.

    Article  Google Scholar 

  57. Anantharaman P, Schmidt RJ. Sexual function in chronic kidney disease. Adv Chronic Kidney Dis. 2007;14(2):119–25.

    Article  PubMed  Google Scholar 

  58. Levy DP, Giatras I, Jungers P. Pregnancy and end-stage renal disease--past experience and new insights. Nephrol Dial Transplant Off Publ Eur Dial Transplant Assoc Eur Ren Assoc. 1998;13(12):3005–7.

    CAS  Google Scholar 

  59. Guazzelli CA, Torloni MR, Sanches TF, Barbieri M, Pestana JO. Contraceptive counseling and use among 197 female kidney transplant recipients. Transplantation. 2008;86(5):669–72.

    Article  PubMed  Google Scholar 

  60. Lim VS. Reproductive function in patients with renal insufficiency. Am J Kidney Dis Off J Nat Kidney Found. 1987;9(4):363–7.

    Article  CAS  Google Scholar 

  61. Handelsman DJ, Dong Q. Hypothalamo-pituitary gonadal axis in chronic renal failure. Endocrinol Metab Clin North Am. 1993;22(1):145–61.

    CAS  PubMed  Google Scholar 

  62. Akbari F, Alavi M, Esteghamati A, Mehrsai A, Djaladat H, Zohrevand R, et al. Effect of renal transplantation on sperm quality and sex hormone levels. BJU Int. 2003;92(3):281–3.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Ann and Robert Lurie Children’s Hospital, Chicago, Illinois, USA

    Allison L. Goetsch

  2. Northwestern University, Chicago, Illinois, USA

    Dana Kimelman & Teresa K. Woodruff

Authors
  1. Allison L. Goetsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dana Kimelman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Teresa K. Woodruff
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Goetsch, A.L., Kimelman, D., Woodruff, T.K. (2017). Chronic Kidney Disease. In: Fertility Preservation and Restoration for Patients with Complex Medical Conditions. Springer, Cham. https://doi.org/10.1007/978-3-319-52316-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-52316-3_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52315-6

  • Online ISBN: 978-3-319-52316-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation