Skip to main content
SpringerLink
Log in

Chronobiology of Polymyalgia Rheumatica and Giant Cell Arteritis

  • Chapter
  • First Online:
Polymyalgia Rheumatica and Giant Cell Arteritis

Abstract

Polymyalgia Rheumatica (PMR), amongst all rheumatic diseases, is characterized by a distinctive diurnal variation in symptoms. This is regulated both by endogenous cortisol and by cytokines so has implications for the dosing of exogenous steroids. A single morning dose of corticosteroid is therefore recommended.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cutolo M, Seriolo B, Craviotto C, Pizzorni C, Sulli A. Circadian rhythms in RA. Ann Rheum Dis. 2003;62:593–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Bellamy N, Sothern RB, Campbell J, Buchanan WW. Circadian rhythm in pain, stiffness, and manual dexterity in rheumatoid arthritis: relation between discomfort and disability. Ann Rheum Dis. 1991;50:243–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Bombardieri S, Clerico A, Riente L, Del Chicca MG, Vitali C. Circadian variations of serum myoglobin levels in normal subjects and patients with polymyositis. Arthritis Rheum. 1982;25:1419–24.

    Article  CAS  PubMed  Google Scholar 

  4. Bhalla AK. Hormones and the immune response. Ann Rheum Dis. 1989;48:1–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kirkham BW, Panayi GS. Diurnal periodicity of Cortisol secretion, immune reactivity and disease activity in rheumatoid arthritis: implications for steroid treatment. Br J Rheumatol. 1989;28:154–7.

    Article  CAS  PubMed  Google Scholar 

  6. Perry MG, Kirwan JR, Jessop DS, Hunt LP. Overnight variations in Cortisol, interleukin 6, tumour necrosis factor a and other cytokines in people with rheumatoid arthritis. Ann Rheum Dis. 2009;68:63–8.

    Google Scholar 

  7. Loubaris N, Cros G, Serrano JJ, Boucard M. Orcadian and circannual variation of the carregeenin inflammatory effect in the rat. Life Sci. 1983;32:1349–54.

    Article  CAS  PubMed  Google Scholar 

  8. Crofford LJ, Kalogeras KTRL. Circadian relationships between interleukin(IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercor-tisolism in patients with early untreated rheumatoid arthritis. J Clin Endocrinol Metab. 1997;82(4):1279–83.

    Article  CAS  PubMed  Google Scholar 

  9. Cutolo M, Maestroni GJM. The melatonin-cytokine connection in rheumatoid arthritis. Ann Rheum Dis. 2005;64:1109–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Bird HA, Esselinckx W, Dixon AS, Mowat AG, Wood PH. An evaluation of criteria for polymyalgia rheumatica. Ann Rheum Dis. 1979;38:434–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Chuang T-Y, Hunder GG, Ilstrup DM, Kurland LT. Polymyalgia rheumatica: a 10-year epidemiologic and clinical study. Ann Intern Med. 1982;97:672–80.

    Article  CAS  PubMed  Google Scholar 

  12. Healey LA. Long-term follow-up of polymyalgia rheumatica: evidence for synovitis. Semin Arthritis Rheum. 1984;13:322–8.

    Article  CAS  PubMed  Google Scholar 

  13. Leeb BF, Rintelen B, Sautner J, Fassl C, Bird HA. The polymyalgia rheumatica activity score in daily use: proposal for a definition of remission. Arthritis Care Res. 2007;57:810–5.

    Article  Google Scholar 

  14. Cutolo M, Montecucco CM, Cavagna L, Caporali R, Capellino S, Montagna P, Fazzuoli L, Villaggio B, Seriolo B, Sulli A. Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis. Ann Rheum Dis. 2006;65:1438–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Straub RH, Georgi J, Heimke K, Vaith P, Lang B. In polymayalgia rheumatica serum prolactin is positively correlated with the number of typical symptoms but not with typical inflammatory markers. Rheumatology. 2002;41:423–9.

    Article  CAS  PubMed  Google Scholar 

  16. Perfetto F, Moggi-Pignone A, Becucci A, Cantini F, Di Natale M, Livi R, Tempestini A, Matucci-Cerinic M. Seasonal pattern in the onset of polymyalgia rheumatica. Ann Rheum Dis. 2005;64:1662–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Buttgereit F, Da Silva JAP, Boers M, Burmester G-R, Cutolo M, Jacobs J, Kirwan J, Kôhler L, van Reil P, Vischer T, JWJ B. Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology. Ann Rheum Dis. 2002;61:718–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Straub RH, Cutolo M. Review: involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum. 2001;44:493–507.

    Article  CAS  PubMed  Google Scholar 

  19. Arvidson NG, Gudbjôrnsson B, Larsson A, Hällgren R. The timing of glucocorticoid administration in rheumatoid arthritis. Ann Rheum Dis. 1997;56:27–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Buttgereit F, Doering G, Schaeffler A, Witte S, Sierakowski S, Gromnica-Ihle E, Jeka S, Krueger K, Szechinski J, Alten R. Efficacy of modified-release versus standard prednisolone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind randomised controlled trial. Lancet. 2008;371:205–14.

    Article  CAS  PubMed  Google Scholar 

  21. Bijlsma JWJ, Jacobs JWG. Glucocorticoid chronotherapy in rheumatoid arthritis. Lancet. 2008;371:183–4.

    Article  PubMed  Google Scholar 

  22. Zakout SA, Clarke LL, Jessop D, Straub RA, Kiwan JR. Circadian variation in plasma IL-6 and the role of modified release prednisone in polymyalgia rheumatica. Int J Clin Rheumatol. 2014;9:431–9.

    Article  Google Scholar 

  23. Hunder GG, Sheps SG, Allen GL, Joyce JW. Daily and alternate-day corticosteroid regimens in treatment of giant cell arteritis: comparison in a prospective study. Ann Intern Med. 1975;82:613–8.

    Article  CAS  PubMed  Google Scholar 

  24. Reinberg A, Lévi F. Clinical chronopharmacology with special reference to NSAIDs. Scand J Rheumatol. 1987;16(Suppl 65):118–22.

    Article  Google Scholar 

  25. Dejaco C, Singh YP, Perel P, Hutchings A, Camellino D, Mackie S, Abril A, Bachta A, Balint P, Barraclough K, et al. 2015 recommendations for the management of Polymyalgia Rheumatica. Arthritis Rheum. 2015;67:2569–80.

    Article  Google Scholar 

  26. DeAndrade JR. Pituitary-adrenocortical reserve during cortico-steroid therapy: a report on the methopyrapone test in ten patients taking long-continued small doses. J Clin Endocrinol Metab. 1964;24:261–2.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Pharmacology Unit, Chapel Allerton Hospital, Leeds, UK

    Howard Bird M.D., F.R.C.P.

Authors
  1. Howard Bird M.D., F.R.C.P.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Howard Bird M.D., F.R.C.P. .

Editor information

Editors and Affiliations

  1. Department of Rheumatology, National Institute of Rheumatic Diseases, Piešťany, Slovakia

    Jozef Rovenský

  2. 2nd Department of Medicine, State Hospital of Stockerau, Stockerau, Austria

    Burkhard Leeb

  3. 2nd Internal Clinic Medical Faculty, Comenius University, Bratislava, Slovakia

    Viera Štvrtinová

  4. Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia

    Richard Imrich

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Bird, H. (2017). Chronobiology of Polymyalgia Rheumatica and Giant Cell Arteritis. In: Rovenský, J., Leeb, B., Štvrtinová, V., Imrich, R. (eds) Polymyalgia Rheumatica and Giant Cell Arteritis. Springer, Cham. https://doi.org/10.1007/978-3-319-52222-7_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-52222-7_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52221-0

  • Online ISBN: 978-3-319-52222-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation