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Involvement of the Aorta in GCA

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Polymyalgia Rheumatica and Giant Cell Arteritis

Abstract

Giant cell arteritis involving aorta, can be a lethal disease and it is often manifested in a dramatic way in the elderly: by dissection or rupture of aorta. Early diagnostics, correct treatment and life-long checks of patients in whom GCA was diagnosed can prevent them from development of such a severe complication as aortic aneurysm. That is why it is necessary to actively seek aneurysms in all GCA patients - make regular duplex ultrasonography examinations, CT or MR examinations if possible, too. Patients with diagnosed GCA shall be carefully and properly treated, since in most of the patients in which aortal dissection developed the treatment was not adequate.

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References

  1. Lie IT. Coronary vasculitis. A review in the current scheme of classification of vasculitis. Arch Pathol Lab Med. 1987;111(3):224–33.

    CAS  PubMed  Google Scholar 

  2. Evans JM, O’Fallon WM, Hunder GG. Increased incidence of aortic aneurysm and dissection in giant cell (temporal) arteritis: a population based study. Ann Intern Med. 1995;122:502–7.

    Article  CAS  PubMed  Google Scholar 

  3. Nuenninghoff DM, Hunder GG, Christianson TJH, et al. Incidence and predictors of a large-artery complication (aortic aneurysm, aortic dissection, and/or large-artery stenosis) in patients with giant cell arteritis. Arthritis Rheum. 2003;48:3522–31.

    Article  PubMed  Google Scholar 

  4. Nuenninghoff DM, Warrington KJ, Matteson EL. Concomitant giant cell aortitis, thoracic aortic aneurysm, an aortic arch syndrome: occurrence in a patient and significance. Arthritis Rheum. 2004;49:858–61.

    Article  Google Scholar 

  5. Weyand CM, Goronzy JJ. Pathogenetic principles in giant cell arteritis. Int J Cardiol. 2000;75(Suppl 1):S9–S15.

    Article  PubMed  Google Scholar 

  6. Ungprasert P, Thongprayoon C, Kittanamongkolchal W, Srivali N, Cheungpasitporn W. Peripheral arterial disease in patients with giant cell arteritis: a meta-analysis. Int J Rheum Dis. 2016;19(8):819–25. doi:10.1111/1756-185X.12631. Epub 2015 Jul 28. [Epub ahead of print].

    Article  PubMed  Google Scholar 

  7. Martínez-Valle F, Solans-Laqué R, Bosch-Gil J, Vilardell-Tarrés M. Aortic involvement in giant cell arteritis. Autoimmun Rev. 2010;9(7):521–4.

    Article  PubMed  Google Scholar 

  8. Gonzalez-Gay MA, Garcia-Porrua C, Gonzalez-Juanatey C, Miranda-Filloy JA, Blanco R, Llorca J. Biopsy-proven giant cell arteritis patients with coronary artery disease have increased risk of aortic aneurysmal disease and arterial thrombosis. Clin Exp Rheumatol. 2013;31(1 Suppl 75):S94.

    CAS  PubMed  Google Scholar 

  9. Meisner RJ, Labropoulos N, Gasparis AP, Tassiopoulos AK. How to diagnose giant cell arteritis. Int Angiol. 2011;30:58–63.

    CAS  PubMed  Google Scholar 

  10. Lie IT. Aortic and extracranial large vessel giant eel arteritis: a review of 72 cases with histopathologic documentation. Semin Arthritis Rheum. 1995;24(6):422–31.

    Article  CAS  PubMed  Google Scholar 

  11. Marie I, Proux A, Duhaut P, et al. Long-term follow-up of aortic involvement in giant cell arteritis: a series of 48 patients. Medicine. 2009;88(3):182–92.

    Article  PubMed  Google Scholar 

  12. Nayar AK, Casciello M, Slim JN, Slim AM. Aortic dissection in a patient with giant cell arteritis: a case report and review of the literature. Case Rep Vasc Med. 2013;2013:590721. doi:10.1155/2013/590721.

    PubMed  PubMed Central  Google Scholar 

  13. Robson JC, Kiran A, Maskell J, Hutchings A, Arden N, Dasgupta B, et al. The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK. Ann Rheum Dis. 2015;74(1):129–34. doi:10.1136/annrheumdis-2013-204113.

    Article  PubMed  Google Scholar 

  14. Säve-Sôderbergh J, Malmwall BE, Andersson R, Bengtsson BA. Giant cell arteritis as a cause of death. JAMA. 1986;255(4):493–6.

    Article  PubMed  Google Scholar 

  15. Lie JT. Illustrated histopathologic classification criteria for selected vasculitis syndromes. Arthritis Rheum. 1990;33(8):1074–87.

    Article  CAS  PubMed  Google Scholar 

  16. Nordborg E, Bengtsson BA, Nordborg C. Temporal artery morphology and morphometry in giant cell arteritis. APMIS. 1991;99:1013–23.

    Article  CAS  PubMed  Google Scholar 

  17. Nordborg C, Nordborg E, Petursdottir V. Giant cell arteritis. Epidemiology, etiology and pathogenesis. APMIS. 2000;108(11):713–24.

    Article  CAS  PubMed  Google Scholar 

  18. Nordborg C, Nordborg E, Petursdottir V. The pathogenesis of giant cell arteritis: morphological aspects. Clin Exp Rheumatol. 2000;18(4 Suppl 20):S18–21.

    CAS  PubMed  Google Scholar 

  19. Nordborg C, Nordborg E, Petursdottir V, Fyhr IM. Calcification of the internal elastic membrane in temporal arteries: its relation to age and gender. Clin Exp Rheumatol. 2001;19(5):565–8.

    CAS  PubMed  Google Scholar 

  20. Štvrtinová V, Rauová Ľ, Tuchyňová A, Rovenský J. Vasculitis of the coronary arteries and atherosclerosis: random coincidence or a causative relationship? In: Shoenfeld Y, Harats D, Wick G, editors. Atherosclerosis and autoimmunity. Amsterdam: Elsevier; 2001. p. 315–27.

    Chapter  Google Scholar 

  21. Weyand CM, Goronzy JJ. Pathogenetic mechanisms in giant cell arteritis. Cleve Clin J Med. 2002;69(Suppl 2):SII28–32.

    PubMed  Google Scholar 

  22. Kaiser M, Younge B, Bjornsson J, et al. Formation of new vasa vasorum in vasculitis, production of angiogenic cytokines by multinucleated giant cells. Am J Pathol. 1999;155(3):765–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Bengtsson BA. Giant cell arteritis. In: Ansell BM, Bacon PA, Lie IT, Yazici H, editors. The vasculitides. Science and practice. London: Chapman and Hall Medical; 1996. p. 171–80.

    Chapter  Google Scholar 

  24. Joyce JW. Arteritis. In: Eastcott HHG, editor. Arterial surgery. Madrid: Churchill Livingstone; 1992. p. 211–22.

    Google Scholar 

  25. Murphy EA, Capell H. Aortitis and large vessel vasculitides. In: Tooke IE, Lowe GDO, editors. A textbook of vascular medicine. London: Arnold; 1996. p. 287–94.

    Google Scholar 

  26. Huston KA, Hunder GG, Lie JT, et al. Temporal arteritis. A 25 year epidemiologic, clinical and pathologic study. Ann Intern Med. 1978;88:162–7.

    Article  CAS  PubMed  Google Scholar 

  27. Liu G, Shupak R, Chiu BK. Aortic dissection in giant cell arteritis. Semin Arthritis Rheum. 1995;25(3):160–71.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Viera Štvrtinová M.D., Ph.D. .

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Štvrtinová, V., Štvrtina, S., Rovenský, J. (2017). Involvement of the Aorta in GCA. In: Rovenský, J., Leeb, B., Štvrtinová, V., Imrich, R. (eds) Polymyalgia Rheumatica and Giant Cell Arteritis. Springer, Cham. https://doi.org/10.1007/978-3-319-52222-7_11

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  • DOI: https://doi.org/10.1007/978-3-319-52222-7_11

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