Abstract
Bifunctional nanosized materials, coassembling magnetic and photonic features into single-entity nanostructures with cooperatively enhanced performances, are remarkable because of their potential multimodal biomedical applications, for example, as drug delivery carriers, MRI contrast agents, and magnetic hyperthermia for cancer therapy. Therefore, extensive research work has been conducted over the last decade to study the magnetic and luminescent properties as well as biomedical applications of bifunctional nanostructures based on magnetic nanoparticles and trivalent rare-earth ions. Another area of great research interest is magnetic and photonic nanomaterials containing magnetic nanoparticles functionalized with quantum dots, fluorescent dyes, and luminescent complexes. The aim of this chapter is to present a concise overview of the key concepts of various strategies to fabricate bifunctional nanomaterials, as well as their magnetism and luminescence behaviors. In keeping with the title of the book, the content of the chapter is presented in an efficient way to facilitate understanding by nonspecialized readers. Finally, the manuscript contains a section on multimodal biomedical applications of magnetic and luminescent nanomaterials.
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Abbreviations
- AA:
-
Acrylic acid
- AC:
-
Alternating current
- Acac:
-
Acetylacetone
- B.M.:
-
Bohr magneton
- Calix:
-
Calixarene
- CNT:
-
Carbon nanotube
- CPE:
-
Carbon-paste electrode
- CS:
-
Chitosan
- CT:
-
Computed tomography
- CTAB:
-
Cetyltrimethyl-ammonium bromide
- Cup:
-
N-nitrosophenylhydroxylamine
- DNA:
-
Deoxyribonucleic acid
- DTAB:
-
Dodecyltrimethylammonium bromide
- FI:
-
Fluorescent imaging
- FITC:
-
Fluorescein isothiocyanate
- GO:
-
Graphene oxide
- IgG:
-
Immunoglobulin G
- IUPAC:
-
International Union of Pure and Applied Chemistry
- IVCT:
-
Intervalence charge transfer
- LBL:
-
Layer-by-layer
- mcDNA:
-
Minicircle DNA
- MNPs:
-
Magnetic nanoparticles
- MRI:
-
Magnetic resonance imaging
- MRT:
-
Magnetic resonance tomography
- MTT:
-
Microculture tetrazolium assay
- MWCNT:
-
Multiwalled carbon nanotube
- NADH:
-
Nicotinamide adenine dinucleotide
- NIR:
-
Near-infrared
- NIPAM:
-
N-isopropylacrylamide
- OA:
-
Oleic acid
- o/w:
-
Oil dispersed in water
- PAH:
-
Poly(allylamine hydrochloride)
- PCEM:
-
Point charge electrostatic model
- PCL:
-
Poly(ε-caprolactone)
- PEG:
-
Polyethylene glycol
- PET:
-
Positron emission tomography
- Phen:
-
1,10-phenanthroline
- PLGA:
-
Poly(lactic-co-glycolic acid)
- PMAA:
-
Poly(methacrylic acid)
- PMI:
-
N-(2,6-diisopropylphenyl)-perylene-3,4-dicarbonacidimide
- PS:
-
Polystyrene
- PSS:
-
Poly(styrenesulfonate)
- PVP:
-
Poly(vinylpyrrolidone)
- QD:
-
Quantum dot
- rGO:
-
Reduced graphene oxide
- SAR:
-
Specific absorption rate
- siRNA:
-
Small interfering RNA
- SLPC:
-
Specific losses per cycle
- SPECT:
-
Single-photon emission computed tomography
- St:
-
Styrene
- TEOS:
-
Tetraethyl orthosilicate
- UCNPs:
-
Upconversion luminescent nanoparticles
- w/o:
-
Water dispersed in oil
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Acknowledgments
The authors are grateful for the financial support of the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil), the World Academy of Sciences (TWAS) for the advancement of science in developing countries, and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Brazil). Priscila V. Khan is gratefully acknowledged for her assistance in the preparation of the figures.
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Khan, L.U., Khan, Z.U. (2017). Bifunctional Nanomaterials: Magnetism, Luminescence and Multimodal Biomedical Applications. In: Sharma, S. (eds) Complex Magnetic Nanostructures. Springer, Cham. https://doi.org/10.1007/978-3-319-52087-2_4
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