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Translatable Models of Brain and Cognitive Reserve

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Neurobiological and Psychological Aspects of Brain Recovery

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

The observation of variation in levels of neuropathology required for individuals to develop cognitive deficits led to the theory of ‘brain and cognitive reserve’ (BCR). This theory posits that there are intrinsic and environmental factors that modify the probability that an individual will develop a neurological disorder in response to a given insult. The development of animal models has allowed this theory to be tested, with rodent experiments demonstrating how environmental factors such as environmental enrichment and exercise levels can ameliorate models of ageing, neurodegeneration and brain injury. Physiological studies in these animal models have identified putative neurobiological mediators of improved BCR from the molecular to anatomical level. Improvements in the development of these models will enable improved testing of the BCR theory and further aid in the quest for developing enviromimetic drugs.

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  1. Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, VIC, 3010, Australia

    Ariel M. Zeleznikow-Johnston, Emma L. Burrows, Thibault Renoir & Anthony J. Hannan

  2. Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC, 3010, Australia

    Anthony J. Hannan

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    Laura Petrosini

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Zeleznikow-Johnston, A.M., Burrows, E.L., Renoir, T., Hannan, A.J. (2017). Translatable Models of Brain and Cognitive Reserve. In: Petrosini, L. (eds) Neurobiological and Psychological Aspects of Brain Recovery. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-319-52067-4_4

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