Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Anti-Inflammatory Properties of Anesthetic Agents

  • Chapter
Annual Update in Intensive Care and Emergency Medicine 2017

Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kurosawa S, Kato M (2008) Anesthetics, immune cells, and immune responses. J Anesth 22:263–277

    Article  PubMed  Google Scholar 

  2. Colucci DG, Puig NR, Hernandez PR (2013) Influence of anesthetic drugs on immune response: from inflammation to immunosuppression. OA Anesthetics 1:21–38

    Google Scholar 

  3. Friedman H, Newton C, Klein TW (2003) Microbial Infections, Immunomodulation, and Drugs of Abuse. Clin Microbiol Rev 16(2):209–219

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Schneemilch CE, Schilling T, Bank U (2004) Effects of general anaesthesia on inflammation. Best Pract Res Clin Anaesthesiol 18:493–507

    Article  CAS  PubMed  Google Scholar 

  5. Elenkov IJ, Chrousos GP (2002) Stress hormones, proinflammtory and anti-inflammatory cytokines, and autoimmunity. Ann NY Acad Sci 966:290–303

    Article  CAS  PubMed  Google Scholar 

  6. Kennedy BC, Hall GM (1999) Neuroendocrine and inflammatory aspects of surgery: do they affect outcome? Acta Anaesthesiol Belg 50:205–209

    CAS  PubMed  Google Scholar 

  7. Graham EA (1911) The influence of ether and ether anesthesia on bacteriolysis, agglutination and phagocytosis. J Infect Dis 8:147–175

    Article  CAS  Google Scholar 

  8. Amin OAI, Salah HE (2011) The effect of general or spinal anaesthesia on pro- and anti-inflammatory intracellular cytokines in patients undergoing appendicectomy using flow cytometric method. Egypt J Anaesth 27:121–125

    Article  CAS  Google Scholar 

  9. Colucci D, Harvey G, Gayol MC, Elena G, Puig N (2011) Halothane anesthesia in mice: effect on the phagocytic activity and respiratory burst of peritoneal macrophages. Neuroimmunomodulation 18:11–18

    Article  CAS  PubMed  Google Scholar 

  10. Simeonova GP, Slovov E, Usunov R, Halacheva K, Dinev DN (2008) Increased apoptosis of peripheral blood mononuclear cells (PBMC) during general and epidural anaesthesia in dogs. Vet Res Commun 32:619–626

    Article  PubMed  Google Scholar 

  11. Loix S, De Kock M, Henin P (2011) The anti-inflammatory effects of ketamine: state of the art. Acta Anaesthesiol Belg 62:47–58

    CAS  PubMed  Google Scholar 

  12. Welters ID, Hafer G, Menzebach A et al (2010) Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappab, Interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines. Anesth Analg 110:934–941

    Article  CAS  PubMed  Google Scholar 

  13. Kock M, Loix S, Lavand’homme P (2013) Ketamine and peripheral inflammation. CNS Neurosci Ther 19:403–410

    Article  PubMed  Google Scholar 

  14. Hirota K, Lambert DG (2011) Ketamine: new uses for an old drug? Br J Anaesth 107:123–126

    Article  CAS  PubMed  Google Scholar 

  15. Memiş D, Hekimoğlu S, Vatan İ, Yandım T, Yüksel M (2007) Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients. Br J Anaesth 98:550–552

    Article  PubMed  Google Scholar 

  16. Zavala F, Haumont J, Lenfant M (1984) Interaction of benzodiazepines with mouse macrophages. Eur J Pharmacol 106:561–566

    Article  CAS  PubMed  Google Scholar 

  17. Nishina K, Akamatsu H, Mikawa K et al (1998) The inhibitory effects of thiopental, midazolam, and ketamine on human neutrophil functions. Anesth Analg 86:159–165

    CAS  PubMed  Google Scholar 

  18. Kim SN, Son SC, Lee SM et al (2006) Midazolam inhibits proinflammatory mediators in the lipopolysaccharide-activated macrophage. Anesthesiology 105:105–110

    Article  CAS  PubMed  Google Scholar 

  19. Frohlich D, Rothe G, Schwall B et al (1996) Thiopentone and propofol, but not methohexitone nor midazolam, inhibit neutrophil oxidative responses to the bacterial peptide FMLP. Eur J Anaesthesiol 13:582–588

    Article  CAS  PubMed  Google Scholar 

  20. Jensen AG, Dahlgren C, Eintrei C (1993) Propofol decreases random and chemotactic stimulated locomotion of human neutrophils in vitro. Br J Anaesth 70:99–100

    Article  CAS  PubMed  Google Scholar 

  21. Mikawa K, Akamatsu H, Nishina K et al (1998) Propofol inhibits human neutrophil functions. Anesth Analg 87:695–700

    CAS  PubMed  Google Scholar 

  22. Cleary TG, Pickering LK (1983) Mechanisms of intralipid effect on polymorphonuclear leukocytes. J Clin Lab Immunol 11:21–26

    CAS  PubMed  Google Scholar 

  23. Pirttinkangas CO, Perttila J, Salo M (1993) Propofol emulsion reduces proliferative responses of lymphocytes from intensive care patients. Intensive Care Med 19:299–302

    Article  Google Scholar 

  24. Hoff G, Bauer I, Larsen B, Bauer M (2001) Modulation of endotoxin-stimulated TNF-alpha gene expression by ketamine and propofol in cultured human whole blood. Anaesthesist 50:494–499

    Article  CAS  PubMed  Google Scholar 

  25. Al-Hashimi M, Scott WM, Thompson JP, Lambert DG (2013) Editor's choice: Opioids and immune modulation: more questions than answers. Br J Anaesth 111:80–88

    Article  CAS  PubMed  Google Scholar 

  26. Sacerdote P (2006) Opioids and the immune system. Palliat Med 20:s9–15

    PubMed  Google Scholar 

  27. Hernandez M, Flores L, Bayer B (1993) Immunosuppression by morphine is mediated by central pathways. J Pharmacol Exp Ther 267:1336–1341

    CAS  PubMed  Google Scholar 

  28. Hall DM, Suo JL, Weber RJ (1998) Opioid mediated effects on the immune system: sympathetic nervous system involvement. J Neuroimmunol 83:29–35

    Article  CAS  PubMed  Google Scholar 

  29. Bidlack JM (2000) Detection and function of opioid receptors on cells from the immune system. Clin Diagn Lab Immunol 7:719–723

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Rittner HL, Brack A, Machelska H et al (2001) Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain. Anesthesiology 95:500–508

    Article  CAS  PubMed  Google Scholar 

  31. Jacobs R, Karst M, Scheinichen D et al (1999) Effects of fentanyl on cellular immune functions in man. Int J Immunopharmacol 21:445–454

    Article  CAS  PubMed  Google Scholar 

  32. Sacerdote P, Gaspani L, Rossoni G et al (2001) Effect of the opioid remifentanil on cellular immune response in the rat. Int J Immunopharmacol 1:713–719

    Article  CAS  Google Scholar 

  33. Eberhardt KE, Thimm BM, Spring A, Maskos WR (1992) Dose-dependent rate of nosocomial pulmonary infection in mechanically ventilated patients with brain oedema receiving barbiturates: a prospective case study. Infection 20:12–18

    Article  CAS  PubMed  Google Scholar 

  34. Chanimov M, Berman S, Weissgarten J et al (2000) Substances used for local and general anaesthesia in major surgery suppress proliferative responsiveness of normal rat peripheral blood mononuclear cells in culture. Eur J Anaesthes 17:248–255

    Article  CAS  Google Scholar 

  35. Cavalcanti V, Santos CL, Samary CS et al (2014) Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury. Respir Physiol Neurobiol 203:45–50

    Article  CAS  PubMed  Google Scholar 

  36. Kang SH, Kim YS, Hong TH et al (2013) Effects of dexmedetomidine on inflammatory responses in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Scand 57:480–487

    Article  CAS  PubMed  Google Scholar 

  37. Li B, Li Y, Tian S et al (2015) Anti-inflammatory effects of perioperative dexmedetomidine administered as an adjunct to general anesthesia: a meta-analysis. Sci Rep 5:12342

    Article  PubMed  PubMed Central  Google Scholar 

  38. Yoon-Mi L, Byeng CS, Kyung-Jin Y (2015) impact of volatile anesthetics on oxidative stress and inflammation. Biomed Res Int 2015:242709

    Google Scholar 

  39. Blum FE, Zuo Z (2013) Volatile anesthetics-induced neuroinflammatory and anti-inflammatory responses. Med Gas Res 3:16

    Article  PubMed  PubMed Central  Google Scholar 

  40. Cassuto J, Sinclair R, Bonderovic M (2006) Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 50:265–282

    Article  CAS  PubMed  Google Scholar 

  41. Hahnenkamp K, Herroeder S, Hollmann MW (2004) Regional anaesthesia, local anaesthetics and the surgical stress response. Best Pract Res Clin Anaesthesiol 18:509–527

    Article  CAS  PubMed  Google Scholar 

  42. Toft P, Tønnesen E (2008) The systemic inflammatory response to anaesthesia and surgery. Curr Anaesth Crit Care 19:349–353

    Article  Google Scholar 

  43. Homburger JA, Meiler SE (2006) Anesthesia drugs, immunity, and long-term outcome. Curr Opin Anaesthesiol 19:423–428

    Article  PubMed  Google Scholar 

  44. Vallejo R, Hord ED, Barna SA, Santiago-Palma J, Ahmed S (2003) Perioperative immunosuppression in cancer patients. J Environ Pathol Toxicol Oncol 22:139–146

    Article  PubMed  Google Scholar 

  45. Kelbel I, Weiss M (2001) Anesthetics and immune function. Curr Opin Anaesthesiol 14:685–691

    Article  CAS  PubMed  Google Scholar 

  46. Lassen HC, Henriksen E, Neukirch F, Kristensen HS (1956) Treatment of tetanus; severe bone-marrow depression after prolonged nitrous-oxide anaesthesia. Lancet 270:527–530

    Google Scholar 

  47. Fellows IW, Byrne AJ, Allison SP (1983) Adrenocortical suppression with etomidate. Lancet 2:54–55

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil

    F. F. Cruz & P. R. M. Rocco

  2. Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino IST, University of Genoa, 16132, Genoa, Italy

    P. Pelosi

Authors
  1. F. F. Cruz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. R. M. Rocco
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Pelosi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. Pelosi .

Editor information

Editors and Affiliations

  1. Dept. of Intensive Care Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium

    Jean-Louis Vincent

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Cruz, F.F., Rocco, P.R.M., Pelosi, P. (2017). Anti-Inflammatory Properties of Anesthetic Agents. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2017. Annual Update in Intensive Care and Emergency Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-51908-1_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-51908-1_32

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-51907-4

  • Online ISBN: 978-3-319-51908-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation