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References
Ponsford JL, Downing MG, Olver J et al (2014) Longitudinal follow-up of patients with traumatic brain injury: outcome at two, five, and ten years post-injury. J Neurotrauma 31:64–77
Jain KK (2008) Neuroprotection in traumatic brain injury. Drug Discov Today 13:1082–1089
Cahill GF Jr, Veech RL (2003) Ketoacids? Good medicine? Trans Am Clin Climatol Assoc 114:149
Reilly P, Bullock R (1997) Head Injury: Pathophysiology and Management of Severe Closed Injury. Chapman & Hall Medical, London
Owen OE, Caprio S, Reichard GA et al (1983) Ketosis of starvation: a revisit and new perspectives. Clin Endocrinol Metab 12:359–379
Jalloh I, Carpenter KLH, Helmy A et al (2015) Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings. Metab Brain Dis 30:615–632
Dash PK, Zhao J, Hergenroeder G et al (2010) Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injury. Neurother J Am Soc Exp Neurother 7:100–114
Andriessen TMJC, Jacobs B, Vos PE (2010) Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury. J Cell Mol Med 14:2381–2392
Cederberg D, Siesjö P (2010) What has inflammation to do with traumatic brain injury? Childs Nerv Syst 26:221–226
Meierhans R, Brandi G, Fasshauer M et al (2012) Arterial lactate above 2 mM is associated with increased brain lactate and decreased brain glucose in patients with severe traumatic brain injury. Minerva Anestesiol 78:185–193
Glenn TC, Kelly DF, Boscardin WJ et al (2003) Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism. J Cereb Blood Flow Metab 23:1239–1250
Jalloh I, Helmy A, Shannon RJ et al (2013) Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study. J Neurotrauma 30:2031–2037
Vespa PM, McArthur D, O’Phelan K et al (2003) Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab 23:865–877
Stein NR, McArthur DL, Etchepare M et al (2012) Early cerebral metabolic crisis after TBI influences outcome despite adequate hemodynamic resuscitation. Neurocrit Care 17:49–57
Nortje J, Coles JP, Timofeev I et al (2008) Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings. Crit Care Med 36:273–281
Bouteldja N, Andersen LT, Møller N et al (2014) Using positron emission tomography to study human ketone body metabolism: A review. Metabolism 63:1375–1384
Marino S, Ciurleo R, Bramanti P et al (2011) 1H-MR spectroscopy in traumatic brain injury. Neurocrit Care 14:127–133
Pan JW, Rothman DL, Behar KL et al (2000) Human brain β-hydroxybutyrate and lactate increase in fasting-induced ketosis. J Cereb Blood Flow Metab 20:1502–1507
Fukao T, Lopaschuk GD, Mitchell GA (2004) Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Prostaglandins Leukot Essent Fatty Acids 70:243–251
Owen OE, Morgan AP, Kemp HG et al (1967) Brain metabolism during fasting. J Clin Invest 46:1589–1595
Veech RL (2004) The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 70:309–319
Prins ML (2008) Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab 28:1–16
Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF Jr (2001) Ketone bodies, potential therapeutic uses. IUBMB Life 51:241–247
Paoli A, Bianco A, Damiani E et al (2014) Ketogenic diet in neuromuscular and neurodegenerative diseases. Biomed Res Int 2014:474296
Stafstrom CE, Rho JM (2012) The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol 3:59
Otto C, Kaemmerer U, Illert B et al (2008) Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides. BMC Cancer 8:122
Freeman JM, Vining EPG, Pillas DJ et al (1998) The efficacy of the ketogenic diet – 1998: A prospective evaluation of intervention in 150 children. Pediatrics 102:1358–1363
Neal EG, Chaffe H, Schwartz RH et al (2008) The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol 7:500–506
Schönfeld P, Reiser G (2013) Why does brain metabolism not favor burning of fatty acids to provide energy? – Reflections on disadvantages of the use of free fatty acids as fuel for brain. J Cereb Blood Flow Metab 33:1493–1499
Schönfeld P, Wojtczak L (2008) Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radic Biol Med 45:231–241
Veech RL (1991) Metabolism of lactate. NMR Biomed 4:53–58
Bouzat P, Oddo M (2014) Lactate and the injured brain: friend or foe? Curr Opin Crit Care 20:133–140
Barros LF (2013) Metabolic signaling by lactate in the brain. Trends Neurosci 36:396–404
Quintard H, Patet C, Zerlauth J-B et al (2016) Improvement of neuroenergetics by hypertonic lactate therapy in patients with traumatic brain injury is dependent on baseline cerebral lactate/pyruvate ratio. J Neurotrauma 33:681–687
Pinto FCG, Capone-Neto A, Prist R et al (2006) Volume replacement with lactated Ringer’s or 3% hypertonic saline solution during combined experimental hemorrhagic shock and traumatic brain injury. J Trauma 60:758–763
Rice AC, Zsoldos R, Chen T et al (2002) Lactate administration attenuates cognitive deficits following traumatic brain injury. Brain Res 928:156–159
Glenn TC, Martin NA, Horning MA et al (2015) Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects. J Neurotrauma 32:820–832
Bouzat P, Sala N, Suys T et al (2014) Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain. Intensive Care Med 40:412–421
Ichai C, Payen J-F, Orban J-C et al (2013) Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial. Intensive Care Med 39:1413–1422
Elkind JA, Lim MM, Johnson BN et al (2015) Efficacy, dosage, and duration of action of branched chain amino Acid therapy for traumatic brain injury. Front Neurol 6:73
Jeter CB, Hergenroeder GW, Ward NH et al (2013) Human mild traumatic brain injury decreases circulating branched-chain amino acids and their metabolite levels. J Neurotrauma 30:671–679
Vuille-Dit-Bille RN, Ha-Huy R, Stover JF (2012) Changes in plasma phenylalanine, isoleucine, leucine, and valine are associated with significant changes in intracranial pressure and jugular venous oxygen saturation in patients with severe traumatic brain injury. Amino Acids 43:1287–1296
Cole JT, Mitala CM, Kundu S et al (2010) Dietary branched chain amino acids ameliorate injury-induced cognitive impairment. Proc Natl Acad Sci USA 107:366–371
Ott LG, Schmidt JJ, Young AB et al (1988) Comparison of administration of two standard intravenous amino acid formulas to severely brain-injured patients. Drug Intell Clin Pharm 22:763–768
Aquilani R, Boselli M, Boschi F et al (2008) Branched-chain amino acids may improve recovery from a vegetative or minimally conscious state in patients with traumatic brain injury: a pilot study. Arch Phys Med Rehabil 89:1642–1647
Aquilani R, Iadarola P, Contardi A et al (2005) Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury. Arch Phys Med Rehabil 86:1729–1735
Borges K, Sonnewald U (2012) Triheptanoin – A medium chain triglyceride with odd chain fatty acids: A new anaplerotic anticonvulsant treatment? Epilepsy Res 100:239–244
Mochel F, DeLonlay P, Touati G et al (2005) Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy. Mol Genet Metab 84:305–312
Kim TH, Borges K, Petrou S et al (2013) Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy. Epilepsy Res 103:101–105
Willis S, Stoll J, Sweetman L et al (2010) Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models. Neurobiol Dis 40:565–572
Adanyeguh IM, Rinaldi D, Henry P-G et al (2015) Triheptanoin improves brain energy metabolism in patients with Huntington disease. Neurology 84:490–495
Schwarzkopf TM, Koch K, Klein J (2015) Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin. Neuroscience 300:201–209
Suzuki M, Suzuki M, Sato K et al (2001) Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats. Jpn J Pharmacol 87:143–150
White H, Venkatesh B, Jones M et al (2013) Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status. Intensive Care Med 39:727–733
Smith SL, Heal DJ, Martin KF (2005) KTX 0101: a potential metabolic approach to cytoprotection in major surgery and neurological disorders. CNS Drug Rev 11:113–140
Clarke K, Tchabanenko K, Pawlosky R et al (2012) Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul Toxicol Pharmacol 63:401–408
White H, Cook D, Venkatesh B (2006) The use of hypertonic saline for treating intracranial hypertension after traumatic brain injury. Anesth Analg 102:1836–1846
Ritter AM, Robertson CS, Goodman JC et al (1996) Evaluation of a carbohydrate-free diet for patients with severe head injury. J Neurotrauma 13:473–485
Hall TC, Bilku DK, Neal CP et al (2016) The impact of an omega-3 fatty acid rich lipid emulsion on fatty acid profiles in critically ill septic patients. Prostaglandins Leukot Essent Fatty Acids 112:1–11
De Bandt JP, Cynober L (2006) Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr 136:308S–313S
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White, H., Kruger, P., Venkatesh, B. (2017). Novel Metabolic Substrates for Feeding the Injured Brain. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2017. Annual Update in Intensive Care and Emergency Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-51908-1_27
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DOI: https://doi.org/10.1007/978-3-319-51908-1_27
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