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Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma pp 57–66Cite as

Clinical Diagnosis of Human ACP

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Abstract

Craniopharyngiomas are epithelial tumours in the sellar/parasellar area accounting for 2–5% of all primary intracranial neoplasms and for up to 15% of intracranial tumours in children. The adamantinomatous histological subtype is the most common and the majority of them (94–95%) have a suprasellar component. Their potential proximity to, and the subsequent pressure effects on vital structures of the brain (visual pathways, brain parenchyma, ventricular system, major blood vessels and hypothalamo-pituitary system) can result to multiple clinical manifestations, the severity of which depends on the location, size and growth potential of the tumour. The main manifestations at diagnosis are neurological, visual and hypothalamo-pituitary with headaches, nausea/vomiting, visual disturbances, growth failure (in children) and hypogonadism (in adults) being the most frequently reported. One or more pituitary hormone deficits may be already present at the time of craniopharyngioma detection in a significant number of patients necessitating early diagnosis and appropriate treatment.

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Authors and Affiliations

  1. Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of Birmingham and Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

    Ashley J. Vardon & Niki Karavitaki

Authors
  1. Ashley J. Vardon
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  2. Niki Karavitaki
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Correspondence to Niki Karavitaki .

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Editors and Affiliations

  1. Developmental Biology and Cancer Programme, Birth Defects Research Centre, Institute of Child Health, University College London, London, United Kingdom

    Juan Pedro Martinez-Barbera

  2. Craniofacial Development and Stem Cell Biology, King’s College London, London, United Kingdom

    Cynthia Lilian Andoniadou

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Vardon, A.J., Karavitaki, N. (2017). Clinical Diagnosis of Human ACP. In: Martinez-Barbera, J., Lilian Andoniadou, C. (eds) Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma. Springer, Cham. https://doi.org/10.1007/978-3-319-51890-9_4

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  • DOI: https://doi.org/10.1007/978-3-319-51890-9_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-51888-6

  • Online ISBN: 978-3-319-51890-9

  • eBook Packages: MedicineMedicine (R0)

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