Abstract
Radiologic procedures form one of the cornerstones of diagnosis in hematological malignancies. Various radiological procedures are essential for the diagnosis, assessment of the therapeutic response, to identify disease relapse, and to evaluate for complications pre- and post-transplantation. The significance of radiology and radiological procedures in stem cell transplantation is expected to grow. In this chapter, we discuss the radiologic procedures and review the key imaging modalities and implications related to pediatric hematopoietic stem cell transplant (HSCT). We will also discuss the role of radionuclide Imaging for patients undergoing hematopoietic stem cell transplantation with a brief review of use of radio-labeled MIBG imaging in children with Neuroblastoma.
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Hollingsworth CL, Frush DP, Kurtzburg J, Prasad VK. Pediatric hematopoietic stem cell transplantation and the role of imaging. Radiology. 2008;248(2):348–65. doi:10.1148/radiol.2482070988.
Levine DS, Navarro OM, Chaudry G, Doyle JJ, Blaser SI. Imaging the complications of bone marrow transplantation in children. Radiographics. 2007;27(2):307–24. doi:10.1148/rg.272065088.
Coy DL, Ormazabal A, Godwin JD, Lalani T. Imaging evaluation of pulmonary and abdominal complications following hematopoietic stem cell transplantation. Radiographics. 2005;25(2):305–18. doi:10.1148/rg.252045037.
Campo LD, León NG, Palacios DC, Lagana C, Tagarro D. Abdominal complications following hematopoietic stem cell transplantation. Radiographics. 2005;25(2):396–412. doi:10.1148/rg.342135046.
Seth R, Puri K, Singh P, Selvam P, Rakesh K. The role of fluorodeoxyglucose positron emission tomography-computerized tomography in resolving therapeutic dilemmas in pediatric Hodgkin lymphoma. Indian J Nucl Med. 2012; 27(3):141–4. doi:10.4103/0972-3919.112717.
Dierickx D, Tousseyn T, Requilé A, et al. The accuracy of positron emission tomography in the detection of posttransplant lymphoproliferative disorder. Haematologica. 2012;98(5):771–5. doi:10.3324/haematol.2012.074500.
Hamadani M, Craig M, Awan FT, Devine SM. How we approach patient evaluation for hematopoietic stem cell transplantation. Bone Marrow Transplant. 2010;45:1259–68. doi:10.1038/bmt.2010.94.
Agool A, Glaudemans AWJM, Boersma HH, Dierckx RAJO, Vellenga E, Slart RHJA. Radionuclide imaging of bone marrow disorders. Eur J Nucl Med Mol Imaging. 2011;38:166–78. doi:10.1007/s00259-010-1531-0.
Eisenberg RL. Clinical imaging: an atlas of differential diagnosis. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2010;978-0-7817-8860-1, 0-7817-8860-9s.
Glaudemans AWJM, Signore A. FDG-PET/CT in infections: the imaging method of choice? Eur J Nucl Med Mol Imaging. 2010;37:1986–91. doi:10.1007/s00259-010-1587-x.
Ady N, Zucker JM, Asselain B, Edeline V, Bonnin F, Michon J, Gongora R, Manil L. A new 123I-MIBG whole body scan scoring method – application to the prediction of the response of metastases to induction chemotherapy in stage IV neuroblastoma. Eur J Cancer. 1995;31a:256–61.
Suc A, Lumbroso J, Rubie H, Hattchouel JM, Boneu A, Rodary C, Robert A, Hartmann O. Metastatic neuroblastoma in children older than one year: prognostic significance of the initial metaiodobenzylguanidine scan and proposal for a scoring system. Cancer. 1996;77:805–11.
Matthay KK, Edeline V, Lumbroso J, Tanguy ML, Asselain B, Zucker JM, Valteau-Couanet D, Hartmann O, Michon J. Correlation of early metastatic response by 123I-metaiodobenzylguanidine scintigraphy with overall response and event-free survival in stage IV neuroblastoma. J Clin Oncol. 2003;21:2486–91.
Katzenstein HM, Cohn SL, Shore RM, Bardo DM, Haut PR, Olszewski M, Schmoldt J, Liu D, Rademaker AW, Kletzel M. Scintigraphic response by 123I-metaiodobenzylguanidine scan correlates with event-free survival in high-risk neuroblastoma. J Clin Oncol. 2004;22:3909–15.
Bleeker G, van Eck-Smit BL, Zwinderman KH, Versteeg R, van Noesel MM, Kam BL, Kaspers GJ, van Schie A, Kreissman SG, Yanik G, Hero B, Schmidt M, Laureys G, Lambert B, Ora I, Schulte JH, Caron HN, Tytgat GA. MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosis. Eur J Nucl Med Mol Imaging. 2015;42:222–30.
Bleeker G, Tytgat GA, Adam JA, Caron HN, Kremer LC, Hooft L, van Dalen EC. 123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma. Cochrane Database Syst Rev. 2015;9:Cd009263.
Matthay KK, Brisse H, Couanet D, Couturier J, Benard J, Mosseri V, Edeline V, Lumbroso J, Valteau-Couanet D, Michon J. Central nervous system metastases in neuroblastoma: radiologic, clinical, and biologic features in 23 patients. Cancer. 2003;98:155–65.
Garaventa A, Gambini C, Villavecchia G, Di Cataldo A, Bertolazzi L, Pizzitola MR, De Bernardi B, Haupt R. Second malignancies in children with neuroblastoma after combined treatment with 131I-metaiodobenzylguanidine. Cancer. 2003;97:1332–8.
Weiss B, Vora A, Huberty J, Hawkins RA, Matthay KK. Secondary myelodysplastic syndrome and leukemia following 131I-metaiodobenzylguanidine therapy for relapsed neuroblastoma. J Pediatr Hematol Oncol. 2003;25:543–7.
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Atiq, M., Harville, T., Shah, N., Mehta, P., Pandey, T., Jethava, Y.S. (2017). Radiologic Procedures Used in Pediatric Stem Cell Transplantation. In: Pandey, T. (eds) Imaging in Stem Cell Transplant and Cell-based Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-51833-6_3
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DOI: https://doi.org/10.1007/978-3-319-51833-6_3
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