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Current Indications and Overview of Molecular Imaging Techniques in Stem Cell Transplantation

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Imaging in Stem Cell Transplant and Cell-based Therapy

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Stem cell transplant has been a focus of clinical research for a long time given its immense promise to treat several difficult to treat and incurable diseases like hematological malignancies, diabetes mellius and neurodegenerative disorders like Parkinson’s disease. Recently there has been a renewed interest in this technique and expansion in applications due to advancement in various stem cell technologies. Traditionally viewed as a core research area; the study of stem cells and cell-based therapies is no longer limited to basic researchers and scientists and is fast getting into the paradigm of clinical care.

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References

  1. Pandey T, Thomas S, Heller MT. Current indications, techniques, and imaging findings of stem cell treatment and bone marrow transplant. Radiol Clin North Am (Elsevier). 2016;54(2).

    Google Scholar 

  2. Nikolic B, Faintuch S, Goldberg SN, Kuo MD, Cardella JF. Stem cell therapy: a primer for interventionalists and imagers. J Vasc Interv Radiol. 2009;20(8):999–1012.

    Article  PubMed  Google Scholar 

  3. BE, Tuch. "Stem cells–a clinical update.." Aust Fam Physician 35, no. 9 (Sep 2006): 719–721.

    Google Scholar 

  4. Thomas ED, Blume KG. Historical markers in the development of allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 1999;5(6):341–6.

    Article  CAS  PubMed  Google Scholar 

  5. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;1145–7.

    Google Scholar 

  6. Shostak S. (Re)defining stem cells. BioEssays. 2006;28(3):301–8.

    Article  PubMed  Google Scholar 

  7. Coppi PD. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007;25(1):100–6.

    Article  PubMed  Google Scholar 

  8. Gratwohl A, Baldomero H, Aljurf M, et al. Hematopoietic stem cell transplantation: a global perspective. JAMA. 2010;303(16):1617–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Hugle T, van Laar JM. Stem cell transplantation for rheumatic autoimmune diseases. Arthritis Res Ther. 2008;10(5):217.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Mascarenhas S, Avalos B, Ardoin SP. An update on stem cell transplantation in autoimmune rheumatologic disorders. Curr Allergy Asthma Rep. 2012;12(6):530–40.

    Article  CAS  PubMed  Google Scholar 

  11. Sullivan KM, Muraro P, Tyndall A. Hematopoietic cell transplantation for autoimmune disease: updates from Europe and the United States. Biol Blood Marrow Transplant. 2010;16(1):S48–56.

    Article  PubMed  Google Scholar 

  12. Tongers J, Losordo DW, Landmesser U. Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. Eur Heart J. 2011;32(10):1197–206.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–72.

    Article  CAS  PubMed  Google Scholar 

  14. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3). (2008):343–53.

    PubMed  Google Scholar 

  15. Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Yin Z, Li H, Zhang Y, Diao Y, Li Y, Chen Y, Sun X, Fisk MB, Skidgel R, Holterman M, Prabhakar B, Mazzone T. Reversal of type 1 diabetes via islet ß cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med. 2012;10:1–11.

    Article  Google Scholar 

  16. Kraitchman DL, Bulte JWM. Imaging of stem cells using MRI. Basic Res Cardiol. 2008;103(2):105–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Modo M, Cash D, Mellodew K, Williams SC, Fraser SE, Meade TJ, Price J, Hodges H. Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. Neuroimage. Oct 2002;17(2):803–11.

    Article  PubMed  Google Scholar 

  18. Qiu B, Xie D, Walczak P, Li X, Ruiz-Cabello J, Minoshima S, Bulte JWM, Yang X. Magnetosonoporation: Instant Magnetic Labeling of Stem Cells. Magn Reson Med. 2010;63:1437–41.

    Article  PubMed  Google Scholar 

  19. Amado LC, Saliaris AP, Schuleri KH, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci. 2005;102:11474–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Kraitchman DL, Heldman AW, Atalar E, et al. In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation. 2003;107:2290–3.

    Article  PubMed  Google Scholar 

  21. Genove G, DeMarco U, Xu H, Goins WF, Ahrens ET. A new transgene reporter for in vivo magnetic resonance imaging. Nat Med. 2005;11(4):450–4.

    Article  CAS  PubMed  Google Scholar 

  22. Gilad AA, McMahon MT, Walczak P, Winnard Jr PT, Raman V, van Laarhoven HW, Skoglund CM, Bulte JW, van Zijl PC. Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol. 2007;25(2):217–9.

    Article  CAS  PubMed  Google Scholar 

  23. Li Z, Suzuki Y, Huang M, Cao F, Xie X, Connolly AJ, Yang PC, Wu JC. Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects. Stem Cells. 2008;26:864–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S. Quantum dots for live cells, in vivo imaging, and diagnostics. Science. 2005;307:538–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Wu JC, Chen IY, Sundaresan G, et al. Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography. Circulation. 2003;108:1302–5.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 2003;17:545–80.

    Article  CAS  PubMed  Google Scholar 

  27. Hoshino K, Ly HQ, Frangioni JV, Hajjar RJ. In vivo tracking in cardiac stem cell-based therapy. Prog Cardiovasc Dis. 2007;49:414–20.

    Article  PubMed  Google Scholar 

  28. Chin BB, Nakamoto Y, Bulte JW, Pittenger MF, Wahl R, Kraitchman DL. 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl Med Commun. 2003;24:1149–54.

    Article  CAS  PubMed  Google Scholar 

  29. Kang WJ, Kang HJ, Kim HS, Chung JK, Lee MC, Lee DS. Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction. J Nucl Med. 2006;47:1295–301.

    PubMed  Google Scholar 

  30. Gambhir SS, Barrio JR, Phelps ME, Iyer M, Namavari M, Satyamurthy N, Wu L, Green LA, Bauer E, MacLaren DC, et al. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci U S A. 1999;96:2333–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Bengel FM, Anton M, Richter T, Simoes MV, Haubner R, Henke J, Erhardt W, Reder S, Lehner T, Brandau W, et al. Noninvasive imaging of transgene expression by use of positron emission tomography in a pig model of myocardial gene transfer. Circulation. 2003;108:2127–33.

    Article  CAS  PubMed  Google Scholar 

  32. Li Z, Wu JC, Sheikh AY, Kraft D, Cao F, Xie X, Patel M, Gambhir SS, Robbins RC, Cooke JP, Wu JC. Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation. 2007;116:I46–54.

    PubMed  PubMed Central  Google Scholar 

  33. Kim YH, Lee DS, Kang JH, Lee YJ, Chung JK, Roh JK, Kim SU, Lee MC. Reversing the silencing of reporter sodium/iodide symporter transgene for stem cell tracking. J Nucl Med. 2005;46:305–11.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University of Arkansas, 4301 West Markham Street, Little Rock, AR, 72205, USA

    Tarun Pandey M.D., F.R.C.R.

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  1. Tarun Pandey M.D., F.R.C.R.
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Correspondence to Tarun Pandey M.D., F.R.C.R. .

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  1. Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Tarun Pandey

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Pandey, T. (2017). Current Indications and Overview of Molecular Imaging Techniques in Stem Cell Transplantation. In: Pandey, T. (eds) Imaging in Stem Cell Transplant and Cell-based Therapy. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-51833-6_1

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