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Cellular Response to Surface Topography and Substrate Stiffness

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Cartilage Regeneration

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Materials can dominate stem cell fate by chemical, biological, topographical and mechanical approaches. Cell feel the cues provided by biomaterial surfaces at both micrometer and nanometer scale, which leads to a series of signal pathways changing dominated by integrin. In addition, as an irregular pattern, the influence of substrate roughness on cellular behavior is also considered in this chapter. Another mechanical cue that affected cell behavior is the stiffness of substrate. Through an understanding of micro/nano-patterns and substrate stiffness that regulate cell behavior and decide stem cells’ fates, a more superior design of biomaterials will be employed in tissue engineering and regenerative medicine.

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Acknowledgements

This work was funded by National Natural Science Foundation of China (81201211, 81471803).

Conflict of Interest: There are no any financial or other relationships with other people or organizations that might lead to a conflict of interest.

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  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China

    Qi Zhang, Shiyun Lin, Qianshun Li, Dan Zhao & Xiaoxiao Cai

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    Yunfeng Lin

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Zhang, Q., Lin, S., Li, Q., Zhao, D., Cai, X. (2017). Cellular Response to Surface Topography and Substrate Stiffness. In: Lin, Y. (eds) Cartilage Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-51617-2_3

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