Cartilage Regeneration pp 21-39 | Cite as
Application of Scaffold Materials in Cartilage Tissue Engineering
- 841 Downloads
Abstract
The management of chondral defects is a challenging topic of current interest for scientists and surgeons. Chondral defects caused by tumor, trauma, infection, congenital malformations are very common in clinical, which seriously affect the patient’s function and quality of life. Even several centuries after its first observation, this problem has still not found a satisfactory and definitive answer. Cartilage tissue engineering, which involves novel natural scaffolds, has emerged as a promising strategy for cartilage regeneration and repair. In this chapter, we aimed to review the application of the scaffold materials in cartilage tissue engineering, including the conditions needed to meet the ideal stent, the preparation of scaffold materials, preparation methods and so on.
Keywords
Chondral defect Cartilage tissue engineering Scaffold Scaffold materials Scaffold fabrication technologyNotes
Acknowledgements
This work was funded by the National Natural Science Foundation of China (81671031, 81470721), Sichuan Science and Technology Innovation Team (2014TD0001).
References
- 1.Musumeci G, Castrogiovanni P, Leonardi R, et al. New perspectives for articular cartilage repair treatment through tissue engineering: a contemporary review. World J Orthod. 2014;5(2):80–8.CrossRefGoogle Scholar
- 2.Hraska V, Photiadis J, Haun C, et al. Pulmonary artery sling with tracheal stenosis. Multimed Man Cardiothorac Surg. 2009(123):mmcts.2008.003343.Google Scholar
- 3.Woo SL, Kwan MK, Lee TQ, et al. Perichondrial autograft for articular cartilage. Shear modulus of neocartilage studied in rabbits. Acta Orthop Scand. 1987;58(5):510–5.PubMedCrossRefGoogle Scholar
- 4.Jacobs JP, Elliott MJ, Haw MP, et al. Pediatric tracheal homograft reconstruction: a novel approach to complex tracheal stenoses in children. J Thorac Cardiovasc Surg. 1996;112(6):1549–58; discussion 1559–60.Google Scholar
- 5.St John KR. The use of compliant layer prosthetic components in orthopedic joint repair and replacement: a review. J Biomed Mater Res B Appl Biomater. 2014;102(6):1332–41.PubMedCrossRefGoogle Scholar
- 6.Tsukada H, Osada H. Experimental study of a new tracheal prosthesis: pored Dacron tube. J Thorac Cardiovasc Surg. 2004;127(3):877–84.PubMedCrossRefGoogle Scholar
- 7.Vacanti JP. Beyond transplantation. Third annual Samuel Jason Mixter lecture. Arch Surg. 1988;123(5):545–9.PubMedCrossRefGoogle Scholar
- 8.Isogai N, Kusuhara H, Ikada Y, et al. Comparison of different chondrocytes for use in tissue engineering of cartilage model structures. Tissue Eng. 2006;12(4):691–703.PubMedCrossRefGoogle Scholar
- 9.Lau TT, Peck Y, Huang W, et al. Optimization of chondrocyte isolation and phenotype characterization for cartilage tissue engineering. Tissue Eng Part C Methods. 2015;21(2):105–11.PubMedCrossRefGoogle Scholar
- 10.Hwang NS, Kim MS, Sampattavanich S, et al. Effects of three-dimensional culture and growth factors on the chondrogenic differentiation of murine embryonic stem cells. Stem Cells. 2006;24(2):284–91.PubMedCrossRefGoogle Scholar
- 11.Fecek C, Yao D, Kacorri A, et al. Chondrogenic derivatives of embryonic stem cells seeded into 3D polycaprolactone scaffolds generated cartilage tissue in vivo. Tissue Eng Part A. 2008;14(8):1403–13.PubMedCrossRefGoogle Scholar
- 12.Wei Y, Zeng W, Wan R, et al. Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix. Eur Cell Mater. 2012;23:1–12.PubMedCrossRefGoogle Scholar
- 13.Imaizumi M, Nomoto Y, Sato Y, et al. Evaluation of the use of induced pluripotent stem cells (iPSCs) for the regeneration of tracheal cartilage. Cell Transplant. 2013;22(2):341–53.PubMedCrossRefGoogle Scholar
- 14.Georgi N, van Blitterswijk C, Karperien M. Mesenchymal stromal/stem cell-or chondrocyte-seeded microcarriers as building blocks for cartilage tissue engineering. Tissue Eng Part A. 2014;20(17–18):2513–23.PubMedCrossRefGoogle Scholar
- 15.Blackburn TA, Craig E. Knee anatomy: a brief review. Phys Ther. 1980;60(12):1556–60.PubMedGoogle Scholar
- 16.Girdler N. Repair of articular defects with autologous mandibular condylar cartilage. J Bone Joint Surg Br. 1993;75(5):710–4.PubMedGoogle Scholar
- 17.Shen J, Li S, Chen D. TGF-β. signaling and the development of osteoarthritis. Bone Res. 2014;2. pii:14002.Google Scholar
- 18.Lin S, Svoboda KK, Feng JQ, et al. The biological function of type I receptors of bone morphogenetic protein in bone. Bone Res. 2016;4:10065.CrossRefGoogle Scholar
- 19.Blaney Davidson E, Van der Kraan P, van Den Berg W. TGF-β and osteoarthritis. Osteoarthritis Cartilage. 2007;15(6):597–604.PubMedCrossRefGoogle Scholar
- 20.Bakker A, van de Loo F, Van Beuningen H, et al. Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. Osteoarthritis Cartilage. 2001;9(2):128–36.PubMedCrossRefGoogle Scholar
- 21.Vinatier C, Mrugala D, Jorgensen C, et al. Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. Trends Biotechnol. 2009;27(5):307–14.PubMedCrossRefGoogle Scholar
- 22.Sachlos E, Czernuszka JT. Making tissue engineering scaffolds work. Review on the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater. 2003;30(5):29–40.CrossRefGoogle Scholar
- 23.Young C, Terada S, Vacanti J, et al. Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res. 2002;81(10):695–700.PubMedCrossRefGoogle Scholar
- 24.Miura M, Gronthos S, Zhao M, et al. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003;100(10):5807–12.PubMedPubMedCentralCrossRefGoogle Scholar
- 25.Lin Y, Gallucci G, Buser D, et al. Bioengineered periodontal tissue formed on titanium dental implants. J Dent Res. 2011;90(2):251–6.PubMedPubMedCentralCrossRefGoogle Scholar
- 26.Sun SJ, Yu WQ, Zhang YL, et al. Effects of TiO2 nanotube layers on RAW 264.7 macrophage behaviour and bone morphogenetic protein-2 expression. Cell Prolif. 2013;46(6):685–94.PubMedCrossRefGoogle Scholar
- 27.Kumada Y, Zhang S. Significant type I and type III collagen production from human periodontal ligament fibroblasts in 3D peptide scaffolds without extra growth factors. PLoS One. 2010;5(4):e10305.PubMedPubMedCentralCrossRefGoogle Scholar
- 28.Guo J, Chen H, Wang Y, et al. A novel porcine acellular dermal matrix scaffold used in periodontal regeneration. Int J Oral Sci. 2013;5(1):37–43.PubMedPubMedCentralCrossRefGoogle Scholar
- 29.Ma PX. Biomimetic materials for tissue engineering. Adv Drug Deliv Rev. 2008;60(2):184–98.PubMedCrossRefGoogle Scholar
- 30.Musumeci G, Loreto C, Castorina S, et al. New perspectives in the treatment of cartilage damage. Poly(ethylene glycol) diacrylate (PEGDA) scaffold. A review. Ital J Anat Embryol. 2013;118:204–10.PubMedGoogle Scholar
- 31.Musumeci G, Carnazza ML, Loreto C, et al. β-defensin-4 (HBD-4) is expressed in chondrocytes derived from normal and osteoarthritic cartilage encapsulated in PEGDA scaffold. Acta Histochem. 2012;114:805–12.PubMedCrossRefGoogle Scholar
- 32.Musumeci G, Loreto C, Carnazza ML, et al. Lubricin is expressed in chondrocytes derived from osteoarthritic cartilage encapsulated in poly (ethylene glycol) diacrylate scaffold. Eur J Histochem. 2011;55:e31.PubMedPubMedCentralCrossRefGoogle Scholar
- 33.Musumeci G, Loreto C, Carnazza ML, et al. OA cartilage derived chondrocytes encapsulated in poly(ethylene glycol) diacrylate (PEGDA) for the evaluation of cartilage restoration and apoptosis in an in vitro model. Histol Histopathol. 2011;26:1265–78.PubMedGoogle Scholar
- 34.Peretti GM, Randolph MA, Villa MT, et al. Cell-based tissue-engineered allogeneic implant for cartilage repair. Tissue Eng. 2000;6:567–76.PubMedCrossRefGoogle Scholar
- 35.Kisiday J, Jin M, Kurz B, et al. Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002;99:9996–10001.PubMedPubMedCentralCrossRefGoogle Scholar
- 36.Kisiday JD, Jin M, DiMicco MA, et al. Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. J Biomech. 2004;37:595–604.PubMedCrossRefGoogle Scholar
- 37.Grande DA, Halberstadt C, Naughton G, et al. Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts. J Biomed Mater Res. 1997;34:211–20.PubMedCrossRefGoogle Scholar
- 38.Grad S, Lee CR, Gorna K, et al. Surface motion upregulates superficial zone protein and hyaluronan production in chondrocyte-seeded threedimensional scaffolds. Tissue Eng. 2005;11:249–56.PubMedCrossRefGoogle Scholar
- 39.Hangody L, Vásárhelyi G, Hangody LR, et al. Autologous osteochondral grafting—technique and long-term results. Injury. 2008;39(Suppl 1):S32–9.PubMedCrossRefGoogle Scholar
- 40.Kang JY, Chung CW, Sung JH, et al. Novel porous matrix of hyaluronic acid for the three-dimensional culture of chondrocytes. Int J Pharm. 2009;369:114–20.PubMedCrossRefGoogle Scholar
- 41.Filová E, Jelínek F, Handl M, et al. Novel composite hyaluronan/type I collagen/fibrin scaffold enhances repair of osteochondral defect in rabbit knee. J Biomed Mater Res B Appl Biomater. 2008;87:415–24.PubMedCrossRefGoogle Scholar
- 42.Masuda K, Sah RL, Hejna MJ, Thonar EJ. A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocyte (ARC) method. J Orthop Res. 2003;21:139–48.PubMedCrossRefGoogle Scholar
- 43.Stoddart MJ, Ettinger L, Häuselmann HJ. Enhanced matrix synthesis in de novo, scaffold free cartilage-like tissue subjected to compression and shear. Biotechnol Bioeng. 2006;95:1043–51.PubMedCrossRefGoogle Scholar
- 44.Grad S, Eglin D, Alini M, Stoddart MJ. Physical stimulation of chondrogenic cells in vitro: a review. Clin Orthop Relat Res. 2011;469:2764–72.PubMedPubMedCentralCrossRefGoogle Scholar
- 45.Iwasa J, Engebretsen L, Shima Y, Ochi M. Clinical application of scaffolds for cartilage tissue engineering. Knee Surg Sports Traumatol Arthrosc. 2009;17(6):561–77.PubMedCrossRefGoogle Scholar
- 46.Grassi A, Zaffagnini S, Marcheggiani Muccioli GM, et al. Clinical outcomes and complications of a collagen meniscus implant: a systematic review. Int Orthop. 2014;38(9):1945–53.PubMedCrossRefGoogle Scholar
- 47.Friess W. Collagen—biomaterial for drug delivery. Eur J Pharm Biopharm. 1998;45(2):113–36.PubMedCrossRefGoogle Scholar
- 48.Steck E, Bertram H, Walther A, et al. Enhanced biochemical and biomechanical properties of scaffolds generated by flock technology for cartilage tissue engineering. Tissue Eng Part A. 2010;16(12):3697–707.PubMedCrossRefGoogle Scholar
- 49.Yuan T, Zhang L, Li K, et al. Collagen hydrogel as an immunomodulatory scaffold in cartilage tissue engineering. J Biomed Mater Res Part B Appl Biomater. 2014;102(2):337–44.PubMedCrossRefGoogle Scholar
- 50.Scotti C, Hirschmann MT, Antinolfi P, et al. Meniscus repair and regeneration: review on current methods and research potential. Eur Cell Mater. 2013;26:150–70.PubMedCrossRefGoogle Scholar
- 51.Martinek V, Ueblacker P, Braun K, et al. Second generation of meniscus transplantation: in-vivo study with tissue engineered meniscus replacement. Arch Orthop Trauma Surg. 2006;126(4):228–34.PubMedCrossRefGoogle Scholar
- 52.Malafaya PB, Silva GA, Reis RL. Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev. 2007;59(4–5):207–33.PubMedCrossRefGoogle Scholar
- 53.Zhao W, Jin X, Cong Y, et al. Degradable natural polymer hydrogels for articular cartilage tissue engineering. J Chem Technol Biotechnol. 2013;88:327–39.CrossRefGoogle Scholar
- 54.Lien S-M, Chien C-H, Huang T-J. A novel osteochondral scaffold of ceramic–gelatin assembly for articular cartilage repair. Mater Sci Eng C. 2009;29:315–21.CrossRefGoogle Scholar
- 55.Xing Q, Zhao F, Chen S, et al. Porous biocompatible threedimensional scaffolds of cellulose microfiber/gelatin composites for cell culture. Acta Biomater. 2010;6(6):2132–9.PubMedCrossRefGoogle Scholar
- 56.Laurent TC, Fraser JR. Hyaluronan. FASEB J. 1992;6(7):2397–404.PubMedGoogle Scholar
- 57.Yoo HS, Lee EA, Yoon JJ, Park TG. Hyaluronic acid modified biodegradable scaffolds for cartilage tissue engineering. Biomaterials. 2005;26(14):1925–33.PubMedCrossRefGoogle Scholar
- 58.Grigolo B, De Franceschi L, Roseti L, et al. Down regulation of degenerative cartilagemolecules in chondrocytes grown on a hyaluronan-based scaffold. Biomaterials. 2005;26(28):5668–76.PubMedCrossRefGoogle Scholar
- 59.Solchaga LA, Temenoff JS, Gao J, et al. Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds. Osteoarthritis Cartilage. 2005;13(4):297–309.PubMedCrossRefGoogle Scholar
- 60.Lebourg M, Rochina JR, Sousa T, et al. Different hyaluronic acid morphology modulates primary articular chondrocyte behavior in hyaluronic acid-coated polycaprolactone scaffolds. J Biomed Mater Res A. 2013;101(2):518–27.PubMedCrossRefGoogle Scholar
- 61.Angele P, Johnstone B, Kujat R, et al. Stem cell based tissue engineering for meniscus repair. J Biomed Mater Res Part A. 2008;85(2):445–55.CrossRefGoogle Scholar
- 62.Zellner J, Mueller M, Berner A, et al. Role of mesenchymal stem cells in tissue engineering of meniscus. J Biomed Mater Res Part A. 2010;94(4):1150–61.Google Scholar
- 63.Zellner J, Hierl K, Mueller M, et al. Stem cell-based tissueengineering for treatment of meniscal tears in the avascular zone. J Biomed Mater Res Part B Appl Biomater. 2013;101(7):1133–42.PubMedCrossRefGoogle Scholar
- 64.Kon E, Filardo G, Tschon M, et al. Tissue engineering for total meniscal substitution: animal study in sheep model—results at 12 months. Tissue Eng Part A. 2012;18(15–16):1573–82.PubMedCrossRefGoogle Scholar
- 65.Ahmed TAE, Dare EV, Hincke M. Fibrin: a versatile scaffold for tissue engineering applications. Tissue Eng Part B Rev. 2008;14(2):199–215.PubMedCrossRefGoogle Scholar
- 66.Eyrich D, Brandl F, Appel B, et al. Long-term stable fibrin gels for cartilage engineering. Biomaterials. 2007;28(1):55–65.PubMedCrossRefGoogle Scholar
- 67.Bensaïd W, Triffitt JT, Blanchat C, et al. A biodegradable fibrin scaffold for mesenchymal stem cell transplantation. Biomaterials. 2003;24(14):2497–502.PubMedCrossRefGoogle Scholar
- 68.Meinel L, Kaplan DL. Silk constructs for delivery of musculoskeletal therapeutics. Adv Drug Deliv Rev. 2012;64(12):1111–22.PubMedPubMedCentralCrossRefGoogle Scholar
- 69.Mandal BB, Park S-H, Gil ES, Kaplan DL. Multilayered silk scaffolds for meniscus tissue engineering. Biomaterials. 2011;32(2):639–51.PubMedCrossRefGoogle Scholar
- 70.Nishimoto H, Kokubu T, Inui A, et al. Ligament regeneration using an absorbable stent-shaped poly-l-lactic acid scaffold in a rabbit model. Int Orthop. 2012;36(11):2379–86.PubMedPubMedCentralCrossRefGoogle Scholar
- 71.Ikeda R, Fujioka H, Nagura I, et al. The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects. Int Orthop. 2009;33(3):821–8.PubMedCrossRefGoogle Scholar
- 72.Garlotta D. A literature review of poly (lactic acid ). J Polym Environ. 2001;9:63–84.CrossRefGoogle Scholar
- 73.Armentano I, Bitinis N, Fortunati E, et al. Multifunctional nanostructured PLA materials for packaging and tissue engineering. Prog Polym Sci. 2013;38:1720–47.CrossRefGoogle Scholar
- 74.Esposito AR, Moda M, Cattani SM, et al. PLDLA/PCLT scaffold for meniscus tissue engineering. Biores Open Access. 2013;2(2):138–47.PubMedPubMedCentralCrossRefGoogle Scholar
- 75.An YH, Woolf SK, Friedman RJ. Pre-clinical in vivo evaluation of orthopaedic bioabsorbable devices. Biomaterials. 2000;21(24):2635–52.PubMedCrossRefGoogle Scholar
- 76.Cui L, Wu Y, Cen L, et al. Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh. Biomaterials. 2009;30(14):2683–93.PubMedCrossRefGoogle Scholar
- 77.Doppalapudi S, Jain A, Khan W, Domb AJ. Biodegradable polymers-an overview. Polym Adv Technol. 2014;25:427–35.CrossRefGoogle Scholar
- 78.McCullen SD, Autefage H, Callanan A, et al. Anisotropic fibrous scaffolds for articular cartilage regeneration. Tissue Eng Part A. 2012;18(19–20):2073–83.PubMedPubMedCentralCrossRefGoogle Scholar
- 79.Anderson AJ, Dawes EA. Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol Rev. 1990;54(4):450–72.PubMedPubMedCentralGoogle Scholar
- 80.Chen GQ, Wu Q. The application of polyhydroxyalkanoates as tissue engineering materials. Biomaterials. 2005;26(33):6565–78.PubMedCrossRefGoogle Scholar
- 81.Deng Y, Zhao K, XF Z, et al. Study on the three-dimensional proliferation of rabbit articular cartilage-derived chondrocytes on polyhydroxyalkanoate scaffolds. Biomaterials. 2002;23(20):4049–56.PubMedCrossRefGoogle Scholar
- 82.Huang W, Shi X, et al. PHBV microspheres–PLGA matrix composite scaffold for bone tissue engineering. Biomaterials. 2010;31(15):4278–85.PubMedCrossRefGoogle Scholar
- 83.Peng Q, Zhang S, et al. Preformed albumin corona, a protective coating for nanoparticles based drug delivery system. Biomaterials. 2013;34(33):8521–30.PubMedCrossRefGoogle Scholar
- 84.Saito Y, Doi Y. Microbial synthesis and properties of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in Comamonas acidovorans. Int J Biol Macromol. 1994;16(2):99–104.PubMedCrossRefGoogle Scholar
- 85.Lenz RW, Marchessault RH. Bacterial polyesters: biosynthesis, biodegradable plastics and biotechnology. Biomacromolecules. 2005;6:1–8.PubMedCrossRefGoogle Scholar
- 86.Saito Y, Nakamura S, Hiramitsu M. Microbial synthesis and properties of poly (3-hydroxybutyrate-co-4-hydroxybutyrate). Polym Int. 1996;39:169–74.CrossRefGoogle Scholar
- 87.Sudesh K, Abe H, Doi Y. Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters. Prog Polym Sci. 2000;25:1503–55.Google Scholar
- 88.Martin DP, Williams SF. Medical applications of poly-4-hydroxybutyrate: a strong flexible absorbable biomaterial. Biochem Eng J. 2003;16:97–105.CrossRefGoogle Scholar
- 89.Zinn M, Witholt B, Egli T. Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate. Adv Drug Deliv Rev. 2001;53:5–21.PubMedCrossRefGoogle Scholar
- 90.Mitomo H, Hsieh W-C, Nishiwaki K, et al. Poly (3-hydroxybutyrate-co-4-hydroxybutyrate) produced by Comamonas acidovorans. Polymer. 2001;42:3455–61.CrossRefGoogle Scholar
- 91.Ishida K, Wang Y, Inoue Y. Comonomer unit composition and thermal properties of poly (3-hydroxybutyrate-co-4-hydroxybutyrate)s biosynthesized by Ralstonia eutropha. Biomacromolecules. 2001;2:1285–93.PubMedCrossRefGoogle Scholar
- 92.Zhu Z, Dakwa P, Tapadia P, et al. Rheological characterization of flow and crystallization behavior of microbial synthesized poly (3-hydroxybutyrate-co-4-hydroxybutyrate). Macromolecules. 2003;36:4891–7.CrossRefGoogle Scholar
- 93.Cong C, Zhang S, Xu R, et al. The influence of 4HB content on the properties of poly (3-hydroxylbutyrate-co-4-hydroxylbutyrate) based on melt molded sheets. J Appl Polym Sci. 2008;109:1962–7.CrossRefGoogle Scholar
- 94.Li X-T, Zhang Y, Chen G-Q. Nanofibrous polyhydroxyalkanoate matrices as cell growth supporting materials. Biomaterials. 2008;29:3720–8.PubMedCrossRefGoogle Scholar
- 95.Cheng S-T, Chen Z-F, Chen G-Q. The expression of crosslinked elastin by rabbit blood vessel smooth muscle cells cultured in polyhydroxyalkanoate scaffolds. Biomaterials. 2008;29:4187–94.PubMedCrossRefGoogle Scholar
- 96.Zheng Z, Bei FF, Tian HL, Chen GQ. Effects of crystallization of polyhydroxyalkanoate blend on surface physicochemical properties and interactions with rabbit articular cartilage chondrocytes. Biomaterials. 2005;26(17):3537–48.PubMedCrossRefGoogle Scholar
- 97.Ji Y, Li XT, Chen GQ. Interactions between a poly (3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) terpolyester and human keratinocytes. Biomaterials. 2008;29(28):3807–14.PubMedCrossRefGoogle Scholar
- 98.Silva GA, Czeisler C, et al. Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science. 2004;303(5662):1352–5.PubMedCrossRefGoogle Scholar
- 99.Xu XY, Li XT, Peng SW, et al. The behaviour of neural stem cells on polyhydroxyalkanoate nanofiber scaffolds. Biomaterials. 2010;31(14):3967–75.PubMedCrossRefGoogle Scholar
- 100.Sun J, Dai Z, Zhao Y, Chen G-Q. In vitro effect of oligohydroxyalkanoates on the growth of mouse fibroblast cell line L929. Biomaterials. 2007;28:3896–903.PubMedCrossRefGoogle Scholar
- 101.Fu N, Deng S, Fu Y, et al. Electrospun P34HB fibres: a scaffold for tissue engineering. Cell Prolif. 2014;47(5):465–75. IF:3.116.Google Scholar
- 102.Fu N, Xie J, Li G, et al. P34HB film promotes cell adhesion, in vitro proliferation, and in vivo cartilage repair. RSC Adv. 2015;5:21572.Google Scholar
- 103.Li G, Fu N, et al. Poly (3-hydroxybutyrate-co-4-hydroxybutyrate) based electrospun 3D scaffolds for delivery of autogeneic chondrocytes and adipose-derived stem cells: evaluation of cartilage defects in rabbit. J Biomed Nanotechnol. 2015;11(1):1–12.CrossRefGoogle Scholar
- 104.Pham QP, Sharma U, Mikos AG, et al. Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration. Biomacromolecules 2006;7:2796–805.Google Scholar
- 105.Tuzlakoglu K, Bolgen N, Salgado AJ, et al. Nano- and micro-fiber combined scaffolds: a new architecture for bone tissue engineering. J Mater Sci Mater Med. 2005;16:1099–1104.Google Scholar
- 106.Coti KK, Belowich ME, Liong M, et al. Mechanised nanoparticles for drug delivery. Nanoscale. 2009;1:16–39.PubMedCrossRefGoogle Scholar
- 107.Zhou S, Deng X, Yang H. Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. Biomaterials. 2003;24:3563–70.PubMedCrossRefGoogle Scholar
- 108.Xie J, MacEwan MR, et al. Electrospun nanofibers for neural tissue engineering. Nanoscale. 2010;2:35–44.PubMedCrossRefGoogle Scholar
- 109.Bakandritsos A, Mattheolabakis G, et al. Preparation, stability and cytocompatibility of magnetic/PLA-PEG hybrids. Nanoscale. 2010;2:564–72.PubMedCrossRefGoogle Scholar
- 110.Zhang D, Tong A, et al. Osteogenic differentiation of human placenta-derived mesenchymal stem cells (PMSCs) on electrospun nanofiber meshes. Cytotechnology. 2012;64:701–10.PubMedPubMedCentralCrossRefGoogle Scholar
- 111.Whang K, Thomas C, Healy K. A novel method to fabricate bioabsorbable scaffolds. Polymer. 1995;36:837–42.CrossRefGoogle Scholar
- 112.Nam YS, Park TG. Biodegradable polymeric microcellular foams by modified thermally induced phase separation method. Biomaterials. 1999;20(19):1783–90.PubMedCrossRefGoogle Scholar
- 113.Agrawal CM, Kennedy ME, Micallef DM. The effects of ultrasound irradiation on a biodegradable 50-50% copolymer of polylactic and polyglycolic acids. J Biomed Mater Res. 1994;28(8):851–9.PubMedCrossRefGoogle Scholar
- 114.Athanasiou K, Schmitz J, Agrawal C. The effect of porosity on in vitro degradation of polylactic acid-polyglycolic acid implants used in repair of articular cartilage. Tissue Eng. 1998;4:53–63.CrossRefGoogle Scholar
- 115.Mikos A, Thorsen A, Czerwonka L, et al. Preparation and characterization of poly (L-lactic acid) foams. Polymer. 1994;35:1068–77.CrossRefGoogle Scholar
- 116.Harris LD, Kim BS, Mooney DJ. Open pore biodegradable matrices formed with gas foaming. J Biomed Mater Res. 1998;42(3):396–402.PubMedCrossRefGoogle Scholar
- 117.Yamada N, Okano T, Sakai H, et al. Thermo-responsive polymeric surfaces; control of attachment and detachment of cultured cells. Makromol Chemie Rapid Commun. 1990;11:571–6.CrossRefGoogle Scholar
- 118.Darling EM, Athanasiou KA. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J Orthop Res. 2005;23(2):425–32.PubMedCrossRefGoogle Scholar
- 119.Domm C, Schunke M, Christesen K, Kurz B. Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension. Osteoarthritis Cartilage. 2002;10(1):13–22.PubMedCrossRefGoogle Scholar
- 120.Malda J, Martens DE, Tramper J, et al. Cartilage tissue engineering: controversy in the effect of oxygen. Crit Rev Biotechnol. 2003;23(3):175–94.PubMedCrossRefGoogle Scholar
- 121.Varma MM, Sravani V, Swamy PV. Design and evaluation of electrospun nanofibers for the enhancement of dissolution rate of meloxicam. J Bionanosci. 2013;7:560.CrossRefGoogle Scholar
- 122.Varma MM, Harika AL, Sravani V. Development and evaluation of lornoxicam loaded electrospun nanofibers for oral extended release. J. Bionanosci. 2013;7(4):360–70.CrossRefGoogle Scholar
- 123.Ji X, Yang W, Wang T, et al. Coaxially electrospun core/shell structured poly(L-lactide) acid/chitosan nanofibers for potential drug carrier in tissue engineering. J Biomed Nanotechnol. 2013;9(10):1672–8.PubMedCrossRefGoogle Scholar
- 124.Ji X, Wang T, Guo L, et al. Effection of nano-ZnO on the mechanical property and biocompatibility of electrospun poly(L-lactide) acid/nano-ZnO mats. J Biomed Nanotechnol. 2013;9(3):417–23.PubMedCrossRefGoogle Scholar
- 125.Shabafrooz V, Mozafari M, Vashaee D, Tayebi L. Electrospun nanofibers: from filtration membranes to highly specialized tissue engineering scaffolds. J Nanosci Nanotechnol. 2014;14(1):522–34.PubMedCrossRefGoogle Scholar
- 126.Wang T, Ji X, Jin L, et al. Fabrication and characterization of heparin-grafted poly-L-lactic acid-chitosan core–shell nanofibers scaffold for vascular gasket. ACS Appl Mater Interfaces. 2013;5(9):3757–63.PubMedCrossRefGoogle Scholar
- 127.Yang W, Fu J, Wang D, et al. Study on CS/PCL blending vascular scaffolds by electrospinning. J Biomed Nanotechnol. 2010;6(3):254–9.PubMedCrossRefGoogle Scholar
- 128.Gu BK, Kim MS, et al. Fabrication of conductive polymer-based nanofiber scaffolds for tissue engineering applications. J Nanosci Nanotechnol. 2014;14(10):7621–6.PubMedCrossRefGoogle Scholar
- 129.Xu J, Li S, Hu F, et al. Artificial biomimicking matrix modifications of nanofibrous scaffolds by hE-Cadherin-Fc fusion protein to promote human mesenchymal stem cells adhesion and proliferation. J Nanosci Nanotechnol. 2014;14(6):4007–13.PubMedCrossRefGoogle Scholar
- 130.Lee OJ, Ju HW, Kim J, et al. Development of artificial dermis using 3D electrospun silk fibroin nanofiber matrix. J Biomed Nanotechnol. 2014;10(7):1294–303.PubMedCrossRefGoogle Scholar
- 131.Huang R, Deng H, Cai T, et al. Layer-by-layer immobilized catalase on electrospun nanofibrous mats protects against oxidative stress induced by hydrogen peroxide. J Biomed Nanotechnol. 2014;10(7):1346–58.PubMedCrossRefGoogle Scholar
- 132.Ghasemi-Mobarakeh L, Prabhakaran MP, Balasubramanian P, et al. Advances in electrospun nanofibers for bone and cartilage regeneration. J Nanosci Nanotechnol. 2013;13(7):4656–71.PubMedCrossRefGoogle Scholar
- 133.Formhals A. Process and apparatus Fob Pbepabing. US patents 1975504; 1934.Google Scholar
- 134.Kenawy E-R, Bowlin GL, Mansfield K, et al. Release of tetracycline hydrochloride from electrospun poly (ethylene-co-vinylacetate), poly (lactic acid), and a blend. J Control Release. 2002;81:57–64.CrossRefGoogle Scholar
- 135.Min B-M, Jeong L, Nam YS, et al. Formation of silk fibroin matrices with different texture and its cellular response to normal human keratinocytes. Int J Biol Macromol. 2004;34:223–30.CrossRefGoogle Scholar
- 136.Yoshimoto H, Shin Y, Terai H, Vacanti J. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials. 2003;24:2077–82.PubMedCrossRefGoogle Scholar
- 137.Li W-J, Tuli R, Okafor C, et al. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials. 2005;26:599–609.PubMedCrossRefGoogle Scholar
- 138.Ekblom P, Vestweber D, Kemler R. Cell-matrix interactions and cell-adhesion during development. Annu Rev Cell Biol. 1986;2:27–47.PubMedCrossRefGoogle Scholar
- 139.Wei G, Jin Q, et al. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials. 2007;28(12):2087–96.PubMedPubMedCentralCrossRefGoogle Scholar
- 140.Zhang H, Jia X, et al. Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration. Biomaterials. 2013;34(9):2202–12.PubMedCrossRefGoogle Scholar
- 141.He S, Shen L, Wu Y, et al. Effect of brain-derived neurotrophic factor on mesenchymal stem cell-seeded electrospinning biomaterial for treating ischemic diabetic ulcers via milieu-dependent differentiation mechanism. Tissue Eng Part A. 2015;21(5–6):928–38.PubMedCrossRefGoogle Scholar
- 142.Briggs T, Matos J, Collins G, Arinzeh TL. Evaluating protein incorporation and release in electrospun composite scaffolds for bone tissue engineering applications. J Biomed Mater Res A. 2015;103(10):3117–27.PubMedCrossRefGoogle Scholar
- 143.Nicknejad ET, Ghoreishi SM, Habibi N. Electrospinning of cross-linked magnetic chitosan nanofibers for protein release. AAPS PharmSciTech. 2015;16(6):1480–6.PubMedPubMedCentralCrossRefGoogle Scholar
- 144.Man Z, Yin L, Shao Z, et al. The effects of co-delivery of BMSC-affinity peptide and rhTGF-beta1 from coaxial electrospun scaffolds on chondrogenic differentiation. Biomaterials. 2014;35(19):5250–60.PubMedCrossRefGoogle Scholar
- 145.Fu W, Liu Z, Feng B, et al. Electrospun gelatin/PCL and collagen/PLCL scaffolds for vascular tissue engineering. Int J Nanomedicine. 2014;9:2335–11.PubMedPubMedCentralCrossRefGoogle Scholar
- 146.Chien HW, Lai JY, Tsai WB. Galactosylated electrospun membranes for hepatocyte sandwich culture. Colloids Surf B Biointerfaces. 2014;116:576–81.PubMedCrossRefGoogle Scholar
- 147.Duan H, Feng B, et al. Engineering of epidermis skin grafts using electrospun nanofibrous gelatin/polycaprolactone membranes. Int J Nanomedicine. 2013;8:2077–84.PubMedPubMedCentralGoogle Scholar