Application of Stem Cells and the Factors Influence Their Differentiation in Cartilage Tissue Engineering

  • Quanquan Ma
  • Taoran Tian
  • Nanxin Liu
  • Mi Zhou
  • Xiaoxiao CaiEmail author
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)


Articular cartilage is a unique tissue which contents only one cell type and lack the ability to heal spontaneously. Current treatment for cartilage defects include non-operative treatment, traditional operative treatment and the cartilage tissue engineering. Among these treatments cartilage tissue engineering have drawn attention to the scientists in recent years. Standard tissue engineering requires three factors: seed cells, scaffold and growth factors. Mature chondrocytes were first used as a seed cell in cartilage tissue engineering. While stem cells, however, have become a new candidate for cartilage tissue engineering. Main sources of stem cell in cartilage tissue engineering consist of embryonic stem cells (ESCs), mesenchymal stem cells (MSCs) and other kinds of stem cells.

In this chapter we will discuss the application of different kinds of stem cells and factors influence their differentiation in cartilage tissue engineering.


Articular cartilage Tissue engineering Stem cell Chondrogenic differentiation Mesenchymal stem cells Embryonic stem cells 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Quanquan Ma
    • 1
  • Taoran Tian
    • 1
  • Nanxin Liu
    • 1
  • Mi Zhou
    • 1
  • Xiaoxiao Cai
    • 1
    Email author
  1. 1.State Key Laboratory of Oral DiseasesWest China Hospital of Stomatology, Sichuan UniversityChengduChina

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