Advertisement

Herpes Simplex

  • Andres PintoEmail author
Chapter

Abstract

  • A careful history of patients who complain of oral lesions will guide the astute clinician toward a correct differential diagnosis for herpes simplex.

  • Particular attention should be placed to early prodromal symptoms of herpes simplex.

  • Early treatment (within 24–48 h of the prodromal cycle) of suspicious herpes simplex lesions is suggested for the efficacy of systemic treatment.

  • Most clinical trial data is derived from studies on HSV-2 or primary infection cases. Concrete evidence for recurrent herpes labialis or recurrent intraoral herpes is limited.

References

  1. 1.
    Stoopler ET, Alfaris S, Alomar D, Sollecito TP. Recurrent Intraoral Herpes. J Emerg Med. 2016. pii: S0736-4679(16)30128-7. doi:  10.1016/j.jemermed.2016.05.001. [Epub ahead of print].
  2. 2.
    Stoopler ET, Sollecito TP. Oral mucosal diseases: evaluation and management. Med Clin N Am. 2014;98(6):1323–52.CrossRefPubMedGoogle Scholar
  3. 3.
    Radulescu M. The pharmacologic management of common lesions of the oral cavity. Dent Clin N Am. 2016;60(2):407–20.CrossRefPubMedGoogle Scholar
  4. 4.
    Corstjens PL, Abrams WR, Malamud D. Saliva and viral infections. Periodontol 2000. 2016;70(1):93–110.CrossRefPubMedGoogle Scholar
  5. 5.
    Miller RM. Diagnosis of herpes simplex virus in patients with erythema multiforme. JAMA. 2014;312(10):1060–1.CrossRefPubMedGoogle Scholar
  6. 6.
    Balasubramaniam R, Kuperstein AS, Stoopler ET. Update on oral herpes virus infections. Dent Clin N Am. 2014;58(2):265–80.CrossRefPubMedGoogle Scholar
  7. 7.
    Goldman RD. Acyclovir for herpetic gingivostomatitis in children. Can Fam Physician. 2016;62(5):403–4.PubMedPubMedCentralGoogle Scholar
  8. 8.
    Xu F, Sternberg MR, Kottiri BJ, et al. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA. 2006;296(8):964–73.CrossRefPubMedGoogle Scholar
  9. 9.
    Kolokotronis A, Doumas S. Herpes simplex virus infection, with particular reference to the progression and complications of primary herpetic gingivostomatitis. Clin Microbiol Infect. 2006;12(3):202–11.CrossRefPubMedGoogle Scholar
  10. 10.
    Sarnoff DS. Treatment of recurrent herpes labialis. J Drugs Dermatol. 2014;13(9):1016–8.PubMedGoogle Scholar
  11. 11.
    Al-Ghazawi FM, Ramien ML, Brassard A, Shear NH, Beecker J. Management of pain associated with selected conditions in dermatology. Am J Clin Dermatol. 2016;17:463–74.CrossRefPubMedGoogle Scholar
  12. 12.
    Zhao M, Zheng R, Jiang J, et al. Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120(6):717–24.CrossRefPubMedGoogle Scholar
  13. 13.
    Chi CC, Wang SH, Delamere FM, et al. Interventions for prevention of herpes simplex labialis (cold sores on the lips). Cochrane Database Syst Rev. 2015;(8):CD010095.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Oral and Maxillofacial Medicine and Diagnostic SciencesUniversity Hospitals Case Medical Center and Case Western Reserve School of Dental MedicineClevelandUSA

Personalised recommendations