Drosophila Malpighian Tubules: A Model for Understanding Kidney Development, Function, and Disease

  • Naveen Kumar Gautam
  • Puja Verma
  • Madhu G. Tapadia
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 60)


The Malpighian tubules of insects are structurally simple but functionally important organs, and their integrity is important for the normal excretory process. They are functional analogs of human kidneys which are important physiological organs as they maintain water and electrolyte balance in the blood and simultaneously help the body to get rid of waste and toxic products after various metabolic activities. In addition, it receives early indications of insults to the body such as immune challenge and other toxic components and is essential for sustaining life. According to National Vital Statistics Reports 2016, renal dysfunction has been ranked as the ninth most abundant cause of death in the USA. This chapter provides detailed descriptions of Drosophila Malpighian tubule development, physiology, immune function and also presents evidences that Malpighian tubules can be used as a model organ system to address the fundamental questions in developmental and functional disorders of the kidney.


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© Springer International Publishing AG 2017

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  • Naveen Kumar Gautam
    • 1
  • Puja Verma
    • 2
  • Madhu G. Tapadia
    • 2
  1. 1.Embryotoxicology Laboratory, Environmental Toxicology DivisionCSIR-Indian Institute of Toxicology Research (CSIR-IITR)LucknowIndia
  2. 2.Department of Zoology, Cytogenetics LaboratoryBanaras Hindu UniversityVaranasiIndia

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