Abstract
Clinical and histological features of dermatomyositis and polymyositis were described 40 years ago. At that time, these two entities comprised the idiopathic inflammatory myopathies. Since then, inclusion body myopathy and necrotizing myopathy have been added to this group of myopathic conditions. While these diseases share common clinical features, they differ in their pathogenesis and histological features. The approach to diagnosis has also changed with the availability of better histological techniques, muscle-specific antigens, and magnetic resonance imaging. Each of these clinical conditions is reviewed as far as clinical presentation, diagnostic approaches, and treatment in the following chapter.
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References
Alfano LN, Lowes LP. Emerging therapeutic options for sporadic inclusion body myositis. Ther Clin Risk Manag. 2015;11:1459–67.
Amato AA, Greenberg SA. Inflammatory myopathies. Continuum (Minneap Minn). 2013;19:119–30.
Betteridge Z, McHugh N. Myositis-specific autoantibodies: an important tool to support diagnosis of myositis. J Intern Med. 2015; doi:10.1111/joim.12451.
Bohan A, Peter JB. Polymyositis and dermatomyositis. N Engl J Med. 1975;292:344–7.
Chhibber S, Amato AA. Clinical evaluation and management of inflammatory myopathies. Semin Neurol. 2015;35:347–59.
Dalakas MC. Inflammatory muscle disease. N Engl J Med. 2015;372:1734–47.
Dimachkie MM, Barohn RJ. Inclusion body myositis. Curr Neurol Neurosci Rep. 2013;13:321. doi:10.1007/s11910-012-0321-4.
Findlay AR, Goyal NA, Mozaffar T. An overview of polymyositis and dermatomyositis. Muscle Nerve. 2015;51:638–56.
Maurer B, Walker UA. Role of MRI in diagnosis and management of idiopathic inflammatory myopathies. Curr Rheumatol Rep. 2015;17:67. doi:10.1007/s11926-015-0544-x.
Michelle EH, Mammen AL. Myositis mimics. Curr Rheumatol Rep. 2015;17:63. doi:10.1007s11926-015-054-0.
Mohassel P, Mammen AL. Statin-associated autoimmune myopathy and anti-HMGCR autoantibodies. Muscle Nerve. 2013;48:477–83.
Needham M, Mastaglia FL. Immunotherapies for immune-mediated myopathies: a current perspective. Neurotherapeutics. 2016;13:132–46.
Tiniakou E, Mammen AL. Idiopathic myopathies and malignancy: a comprehensive review. Clin Rev Allergy Immunol. 2015; doi:10.1007/s12016-015-8511.x.
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Schwendimann, R.N. (2017). Idiopathic Inflammatory Myopathies. In: Minagar, A., Alexander, J. (eds) Inflammatory Disorders of the Nervous System. Current Clinical Neurology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-51220-4_12
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DOI: https://doi.org/10.1007/978-3-319-51220-4_12
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