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Giant Cell Tumor of the Sacrum

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Tumors of the Sacrum

Abstract

Giant cell tumors (GCTs) are relatively common, locally aggressive benign neoplasms of bone that demonstrate a high risk for local recurrence and an occasional propensity for metastatic dissemination [1, 2]. The sacrum is the third most common location of GCTs after the knee and distal radius and the most common location in the axial skeleton [1–4]. Most affected patients are between 20 and 40 years old, with approximately 70% of cases occurring in this age group [1].

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References

  1. Dorfman HD, Czerniak B. Bone tumors. St. Louis: Mosby; 1998.

    Google Scholar 

  2. Randall RL. Giant cell tumor of the sacrum. Neurosurg Focus. 2003;15(2):E13.

    Article  PubMed  Google Scholar 

  3. Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69(1):106–14.

    Article  CAS  PubMed  Google Scholar 

  4. Ruggieri P, Mavrogenis AF, Ussia G, Angelini A, Papagelopoulos PJ, Mercuri M. Recurrence after and complications associated with adjuvant treatments for sacral giant cell tumor. Clin Orthop Relat Res. 2010;468(11):2954–61. doi:10.1007/s11999-010-1448-8.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Chen KH, Wu PK, Chen CF, Chen WM. Zoledronic acid-loaded bone cement as a local adjuvant therapy for giant cell tumor of the sacrum after intralesional curettage. Eur Spine J. 2015;24(10):2182–8. doi:10.1007/s00586-015-3978-y.

    Article  PubMed  Google Scholar 

  6. Leggon RE, Zlotecki R, Reith J, Scarborough MT. Giant cell tumor of the pelvis and sacrum: 17 cases and analysis of the literature. Clin Orthop Relat Res. 2004;423:196–207.

    Article  Google Scholar 

  7. Turcotte RE. Giant cell tumor of bone. Orthop Clin North Am. 2006;37(1):35–51. doi:10.1016/j.ocl.2005.08.005.

    Article  PubMed  Google Scholar 

  8. Zhang K, Chen K, Zhou M, Chen H, Lu J, Yang H. Extremely large giant-cell tumor of sacrum with successful resection via posterior approach. Spine J. 2015;15(7):1684–5. doi:10.1016/j.spinee.2015.02.007.

    Article  PubMed  Google Scholar 

  9. Feigenberg SJ, Marcus Jr RB, Zlotecki RA, Scarborough MT, Berrey BH, Enneking WF. Radiation therapy for giant cell tumors of bone. Clin Orthop Relat Res. 2003;411:207–16. doi:10.1097/01.blo.0000069890.31220.b4.

    Article  Google Scholar 

  10. Reid R, Banerjee S, Sciot R. Giant cell tumour. In: Fletcher D, Unni K, Mertens F, editors. WHO Classification of tumors. Pathology and genetics: tumors of soft tissue and bone. Lyon: IARC Press; 2002. p. 310–2.

    Google Scholar 

  11. Kransdorf M, Murphey M. Giant cell tumor. In: Davies M, Sundaram M, James S, editors. Imaging of bone tumors and tumor-like lesions. Berlin: Springer; 2009. p. 321–36.

    Chapter  Google Scholar 

  12. Dahlin DC, Cupps RE, Johnson Jr EW. Giant-cell tumor: a study of 195 cases. Cancer. 1970;25(5):1061–70.

    Article  CAS  PubMed  Google Scholar 

  13. Resnick D. Diagnosis of bone and joint disorders. 3rd ed. Philadelphia: Saunders; 1995.

    Google Scholar 

  14. Unni KK, Dahlin DC. Dahlin’s bone tumors: general aspects and data on 11,087 cases. 5th ed. Philadelphia: Lippincott-Raven; 1996.

    Google Scholar 

  15. Guo W, Ji T, Tang X, Yang Y. Outcome of conservative surgery for giant cell tumor of the sacrum. Spine. 2009;34(10):1025–31. doi:10.1097/BRS.0b013e31819d4127.

    Article  PubMed  Google Scholar 

  16. Thangaraj R, Grimer RJ, Carter SR, Stirling AJ, Spilsbury J, Spooner D. Giant cell tumour of the sacrum: a suggested algorithm for treatment. Eur Spine J. 2010;19(7):1189–94. doi:10.1007/s00586-009-1270-8.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Martin C, McCarthy EF. Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature. Iowa Orthop J. 2010;30:69–75.

    PubMed  PubMed Central  Google Scholar 

  18. van der Heijden L, van de Sande MA, van der Geest IC, Schreuder HW, van Royen BJ, Jutte PC, Bramer JA, Oner FC, van Noort-Suijdendorp AP, Kroon HM, Dijkstra PD. Giant cell tumors of the sacrum—a nationwide study on midterm results in 26 patients after intralesional excision. Eur Spine J. 2014;23(9):1949–62. doi:10.1007/s00586-014-3263-5.

    Article  PubMed  Google Scholar 

  19. Bloem JL, Reidsma II. Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 2012;81(12):3793–801. doi:10.1016/j.ejrad.2011.03.101.

    Article  PubMed  Google Scholar 

  20. Saikia B, Goel A, Gupta SK. Fine-needle aspiration cytologic diagnosis of giant-cell tumor of the sacrum presenting as a rectal mass: a case report. Diagn Cytopathol. 2001;24(1):39–41.

    Article  CAS  PubMed  Google Scholar 

  21. Payer M. Neurological manifestation of sacral tumors. Neurosurg Focus. 2003;15(2):E1. doi:10.3171/foc.2003.15.2.1.

    Article  PubMed  Google Scholar 

  22. Althausen PL, Schneider PD, Bold RJ, Gupta MC, Goodnight Jr JE, Khatri VP. Multimodality management of a giant cell tumor arising in the proximal sacrum: case report. Spine. 2002;27(15):E361–5.

    Article  PubMed  Google Scholar 

  23. Higuchi T, Taki J, Sumiya H, Kinuya S, Bunko H, Nonomura A, Tsuchiya H, Tonami N. Intense 201 Tl uptake in giant-cell tumour of bone. Nucl Med Commun. 2002;23(6):595–9.

    Article  CAS  PubMed  Google Scholar 

  24. Mavrogenis AF, Patapis P, Kostopanagiotou G, Papagelopoulos PJ. Tumors of the sacrum. Orthopedics. 2009;32(5):342.

    Article  PubMed  Google Scholar 

  25. van der Heijden L, Dijkstra PD, van de Sande MA, Kroep JR, Nout RA, van Rijswijk CS, Bovee JV, Hogendoorn PC, Gelderblom H. The clinical approach toward giant cell tumor of bone. Oncologist. 2014;19(5):550–61. doi:10.1634/theoncologist.2013-0432.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT, Kransdorf MJ. From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 2001;21(5):1283–309. doi:10.1148/radiographics.21.5.g01se251283.

    Article  CAS  PubMed  Google Scholar 

  27. Chakarun CJ, Forrester DM, Gottsegen CJ, Patel DB, White EA, Matcuk Jr GR. Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics. 2013;33(1):197–211. doi:10.1148/rg.331125089.

    Article  PubMed  Google Scholar 

  28. Manaster BJ, Graham T. Imaging of sacral tumors. Neurosurg Focus. 2003;15(2):E2.

    Article  PubMed  Google Scholar 

  29. Gerber S, Ollivier L, Leclere J, Vanel D, Missenard G, Brisse H, de Pinieux G, Neuenschwander S. Imaging of sacral tumours. Skeletal Radiol. 2008;37(4):277–89. doi:10.1007/s00256-007-0413-4.

    Article  CAS  PubMed  Google Scholar 

  30. Wang K, Allen L, Fung E, Chan CC, Chan JC, Griffith JF. Bone scintigraphy in common tumors with osteolytic components. Clin Nucl Med. 2005;30(10):655–71.

    Article  CAS  PubMed  Google Scholar 

  31. Levine E, De Smet AA, Neff JR, Martin NL. Scintigraphic evaluation of giant cell tumor of bone. AJR Am J Roentgenol. 1984;143(2):343–8. doi:10.2214/ajr.143.2.343.

    Article  CAS  PubMed  Google Scholar 

  32. Levine E, De Smet AA, Neff JR. Role of radiologic imaging in management planning of giant cell tumor of bone. Skeletal Radiol. 1984;12(2):79–89.

    Article  CAS  PubMed  Google Scholar 

  33. Hosalkar HS, Jones KJ, King JJ, Lackman RD. Serial arterial embolization for large sacral giant-cell tumors: mid- to long-term results. Spine. 2007;32(10):1107–15. doi:10.1097/01.brs.0000261558.94247.8d.

    Article  PubMed  Google Scholar 

  34. Lackman RD, Khoury LD, Esmail A, Donthineni-Rao R. The treatment of sacral giant-cell tumours by serial arterial embolisation. J Bone Joint Surg Br. 2002;84(6):873–7.

    Article  CAS  PubMed  Google Scholar 

  35. Lin PP, Guzel VB, Moura MF, Wallace S, Benjamin RS, Weber KL, Morello Jr FA, Gokaslan ZL, Yasko AW. Long-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolization. Cancer. 2002;95(6):1317–25. doi:10.1002/cncr.10803.

    Article  PubMed  Google Scholar 

  36. Thomas DM. RANKL, denosumab, and giant cell tumor of bone. Curr Opin Oncol. 2012;24(4):397–403. doi:10.1097/CCO.0b013e328354c129.

    Article  CAS  PubMed  Google Scholar 

  37. Roux S, Amazit L, Meduri G, Guiochon-Mantel A, Milgrom E, Mariette X. RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. Am J Clin Pathol. 2002;117(2):210–6. doi:10.1309/BPET-F2PE-P2BD-J3P3.

    Article  CAS  PubMed  Google Scholar 

  38. Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J Orthop Res. 2005;23(1):203–9. doi:10.1016/j.orthres.2004.06.018.

    Article  PubMed  Google Scholar 

  39. Rao UN, Goodman M, Chung WW, Swalski P, Pal R, Finkelstein S. Molecular analysis of primary and recurrent giant cell tumors of bone. Cancer Genet Cytogenet. 2005;158(2):126–36. doi:10.1016/j.cancergencyto.2004.09.015.

    Article  CAS  PubMed  Google Scholar 

  40. Gorunova L, Vult von Steyern F, Storlazzi CT, Bjerkehagen B, Folleras G, Heim S, Mandahl N, Mertens F. Cytogenetic analysis of 101 giant cell tumors of bone: nonrandom patterns of telomeric associations and other structural aberrations. Genes Chromosomes Cancer. 2009;48(7):583–602. doi:10.1002/gcc.20667.

    Article  CAS  PubMed  Google Scholar 

  41. Forsyth RG, De Boeck G, Bekaert S, De Meyer T, Taminiau AH, Uyttendaele D, Roels H, Praet MM, Hogendoorn PC. Telomere biology in giant cell tumour of bone. J Pathol. 2008;214(5):555–63. doi:10.1002/path.2301.

    Article  CAS  PubMed  Google Scholar 

  42. Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N, Van Loo P, Wedge DC, Cooke SL, Gundem G, Davies H, Nik-Zainal S, Martin S, McLaren S, Goody V, Robinson B, Butler A, Teague JW, Halai D, Khatri B, Myklebost O, Baumhoer D, Jundt G, Hamoudi R, Tirabosco R, Amary MF, Futreal PA, Stratton MR, Campbell PJ, Flanagan AM. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet. 2013;45(12):1479–82. doi:10.1038/ng.2814.

    Article  CAS  PubMed  Google Scholar 

  43. Oda Y, Sakamoto A, Saito T, Matsuda S, Tanaka K, Iwamoto Y, Tsuneyoshi M. Secondary malignant giant-cell tumour of bone: molecular abnormalities of p53 and H-ras gene correlated with malignant transformation. Histopathology. 2001;39(6):629–37.

    Article  CAS  PubMed  Google Scholar 

  44. Saito T, Mitomi H, Izumi H, Suehara Y, Okubo T, Torigoe T, Takagi T, Kaneko K, Sato K, Matsumoto T, Yao T. A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. Hum Pathol. 2011;42(5):727–33. doi:10.1016/j.humpath.2010.08.008.

    Article  CAS  PubMed  Google Scholar 

  45. Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G. Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol. 2008;134(9):969–78. doi:10.1007/s00432-008-0370-x.

    Article  CAS  PubMed  Google Scholar 

  46. Sanerkin NG. Malignancy, aggressiveness, and recurrence in giant cell tumor of bone. Cancer. 1980;46(7):1641–9.

    Article  CAS  PubMed  Google Scholar 

  47. Dominkus M, Ruggieri P, Bertoni F, Briccoli A, Picci P, Rocca M, Mercuri M. Histologically verified lung metastases in benign giant cell tumours—14 cases from a single institution. Int Orthop. 2006;30(6):499–504. doi:10.1007/s00264-006-0204-x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Donthineni R, Boriani L, Ofluoglu O, Bandiera S. Metastatic behaviour of giant cell tumour of the spine. Int Orthop. 2009;33(2):497–501. doi:10.1007/s00264-008-0560-9.

    Article  PubMed  Google Scholar 

  49. Siebenrock KA, Unni KK, Rock MG. Giant-cell tumour of bone metastasising to the lungs. A long-term follow-up. J Bone Joint Surg Br. 1998;80(1):43–7.

    Article  CAS  PubMed  Google Scholar 

  50. Lewis VO. What’s new in musculoskeletal oncology. J Bone Joint Surg Am. 2007;89(6):1399–407. doi:10.2106/JBJS.G.00075.

    Article  PubMed  Google Scholar 

  51. Mirra JM, Picci P, Gold RH. Bone tumors: clinical, radiologic, and pathologic correlations. Philadelphia: Lea & Febiger; 1989.

    Google Scholar 

  52. Horvai A, Unni KK. Premalignant conditions of bone. J Orthop Sci. 2006;11(4):412–23. doi:10.1007/s00776-006-1037-6.

    Article  PubMed  PubMed Central  Google Scholar 

  53. McDonald DJ, Sim FH, McLeod RA, Dahlin DC. Giant-cell tumor of bone. J Bone Joint Surg Am. 1986;68(2):235–42.

    Article  CAS  PubMed  Google Scholar 

  54. Turcotte RE, Sim FH, Unni KK. Giant cell tumor of the sacrum. Clin Orthop Relat Res. 1993;291:215–21.

    Google Scholar 

  55. Marcove RC, Sheth DS, Brien EW, Huvos AG, Healey JH. Conservative surgery for giant cell tumors of the sacrum. The role of cryosurgery as a supplement to curettage and partial excision. Cancer. 1994;74(4):1253–60.

    Article  CAS  PubMed  Google Scholar 

  56. Gaztanaga M, Aristu J, Villas C, San-Julian M. Giant cell tumors of the sacrum treated with intralesional resection and radiotherapy: a case series and review of the literature. Eur Orthop Traumatol. 2011;1:175–9.

    Article  Google Scholar 

  57. Li G, Fu D, Chen K, Ma X, Sun M, Sun W, Li J, Cai Z. Surgical strategy for the management of sacral giant cell tumors: a 32-case series. Spine J. 2012;12(6):484–91. doi:10.1016/j.spinee.2012.06.014.

    Article  PubMed  Google Scholar 

  58. Eftekhari F, Wallace S, Chuang VP, Soo CS, Cangir A, Benjamin RS, Murray JA. Intraarterial management of giant-cell tumors of the spine in children. Pediatr Radiol. 1982;12(6):289–93.

    Article  CAS  PubMed  Google Scholar 

  59. Gottfried ON, Schmidt MH, Stevens EA. Embolization of sacral tumors. Neurosurg Focus. 2003;15(2):E4.

    Article  PubMed  Google Scholar 

  60. Kollender Y, Meller I, Bickels J, Flusser G, Issakov J, Merimsky O, Marouani N, Nirkin A, Weinbroum AA. Role of adjuvant cryosurgery in intralesional treatment of sacral tumors. Cancer. 2003;97(11):2830–8. doi:10.1002/cncr.11383.

    Article  PubMed  Google Scholar 

  61. Ozaki T, Liljenqvist U, Halm H, Hillmann A, Gosheger G, Winkelmann W. Giant cell tumor of the spine. Clin Orthop Relat Res. 2002;401:194–201.

    Article  Google Scholar 

  62. Persson BM, Ekelund L, Lovdahl R, Gunterberg B. Favourable results of acrylic cementation for giant cell tumors. Acta Orthop Scand. 1984;55(2):209–14.

    Article  CAS  PubMed  Google Scholar 

  63. Raque Jr GH, Vitaz TW, Shields CB. Treatment of neoplastic diseases of the sacrum. J Surg Oncol. 2001;76(4):301–7.

    Article  PubMed  Google Scholar 

  64. Sar C, Eralp L. Surgical treatment of primary tumors of the sacrum. Arch Orthop Trauma Surg. 2002;122(3):148–55. doi:10.1007/s00402-001-0356-5.

    Article  PubMed  Google Scholar 

  65. Kivioja AH, Blomqvist C, Hietaniemi K, Trovik C, Walloe A, Bauer HC, Jorgensen PH, Bergh P, Folleras G. Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 years. Acta Orthop. 2008;79(1):86–93. doi:10.1080/17453670710014815.

    Article  PubMed  Google Scholar 

  66. Algawahmed H, Turcotte R, Farrokhyar F, Ghert M. High-speed burring with and without the use of surgical adjuvants in the intralesional management of giant cell tumor of bone: a systematic review and meta-analysis. Sarcoma. 2010; doi:10.1155/2010/586090.

    PubMed  PubMed Central  Google Scholar 

  67. Errani C, Ruggieri P, Asenzio MA, Toscano A, Colangeli S, Rimondi E, Rossi G, Longhi A, Mercuri M. Giant cell tumor of the extremity: a review of 349 cases from a single institution. Cancer Treat Rev. 2010;36(1):1–7. doi:10.1016/j.ctrv.2009.09.002.

    Article  PubMed  Google Scholar 

  68. Klenke FM, Wenger DE, Inwards CY, Rose PS, Sim FH. Giant cell tumor of bone: risk factors for recurrence. Clin Orthop Relat Res. 2011;469(2):591–9. doi:10.1007/s11999-010-1501-7.

    Article  PubMed  Google Scholar 

  69. Trieb K, Bitzan P, Lang S, Dominkus M, Kotz R. Recurrence of curetted and bone-grafted giant-cell tumours with and without adjuvant phenol therapy. Eur J Surg Oncol. 2001;27(2):200–2. doi:10.1053/ejso.2000.1086.

    Article  CAS  PubMed  Google Scholar 

  70. Gaston CL, Bhumbra R, Watanuki M, Abudu AT, Carter SR, Jeys LM, Tillman RM, Grimer RJ. Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone? J Bone Joint Surg Br. 2011;93(12):1665–9. doi:10.1302/0301-620X.93B12.27663.

    Article  CAS  PubMed  Google Scholar 

  71. Wuisman P, Lieshout O, Sugihara S, van Dijk M. Total sacrectomy and reconstruction: oncologic and functional outcome. Clin Orthop Relat Res. 2000;381:192–203.

    Article  Google Scholar 

  72. Chawla S, Henshaw R, Seeger L, Choy E, Blay JY, Ferrari S, Kroep J, Grimer R, Reichardt P, Rutkowski P, Schuetze S, Skubitz K, Staddon A, Thomas D, Qian Y, Jacobs I. Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study. Lancet Oncol. 2013;14(9):901–8. doi:10.1016/S1470-2045(13)70277-8.

    Article  CAS  PubMed  Google Scholar 

  73. Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, Dansey R, Jun S. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010;11(3):275–80. doi:10.1016/S1470-2045(10)70010-3.

    Article  CAS  PubMed  Google Scholar 

  74. Shi W, Indelicato DJ, Reith J, Smith KB, Morris CG, Scarborough MT, Gibbs Jr CP, Mendenhall WM, Zlotecki RA. Radiotherapy in the management of giant cell tumor of bone. Am J Clin Oncol. 2013;36(5):505–8. doi:10.1097/COC.0b013e3182568fb6.

    Article  CAS  PubMed  Google Scholar 

  75. Ruka W, Rutkowski P, Morysinski T, Nowecki Z, Zdzienicki M, Makula D, Ptaszynski K, Bylina E, Grzesiakowska U. The megavoltage radiation therapy in treatment of patients with advanced or difficult giant cell tumors of bone. Int J Radiat Oncol Biol Phys. 2010;78(2):494–8. doi:10.1016/j.ijrobp.2009.07.1704.

    Article  PubMed  Google Scholar 

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Conflict-of-Interest Statement

No benefits have been or will be received from a commercial party related directly or indirectly to the subject matter of this article.

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Authors and Affiliations

  1. First Department of Orthopaedics, National and Kapodistrian University of Athens, Athens, Greece

    Andreas F. Mavrogenis M.D.,Ph.D. & Georgios N. Panagopoulos M.D.

  2. Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

    Andrea Angelini M.D., Ph.D. & Pietro Ruggieri M.D., Ph.D.

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  1. Andreas F. Mavrogenis M.D.,Ph.D.
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  2. Georgios N. Panagopoulos M.D.
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  3. Andrea Angelini M.D., Ph.D.
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  4. Pietro Ruggieri M.D., Ph.D.
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Correspondence to Pietro Ruggieri M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Padova, Italy

    Pietro Ruggieri

  2. Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Padova, Italy

    Andrea Angelini

  3. Department of Pathology, Istituto Ortopedico Rizzoli, Bologna, Italy

    Daniel Vanel

  4. Laboratory of Experimental Oncology, Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy

    Piero Picci

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Mavrogenis, A.F., Panagopoulos, G.N., Angelini, A., Ruggieri, P. (2017). Giant Cell Tumor of the Sacrum. In: Ruggieri, P., Angelini, A., Vanel, D., Picci, P. (eds) Tumors of the Sacrum. Springer, Cham. https://doi.org/10.1007/978-3-319-51202-0_8

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