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Medical Management of Psychotropic Side Effects pp 59–66Cite as

QTc Prolongation

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Abstract

The EKG waveform starts with the P wave, which represents atrial depolarization and ends with the T wave, which represents the end of ventricular repolarization.

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References

  1. Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC. QTc prolongation, torsades de pointes, and psychotropic medications. Psychosomatics. 2013;54(1):1–13.

    Article  PubMed  Google Scholar 

  2. Glassman AH, Bigger Jr JT. Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am J Psychiatry. 2001;158(11):1774–82.

    Article  CAS  PubMed  Google Scholar 

  3. Strom BL, Eng SM, Faich G, Reynolds RF, D’Agostino RB, Ruskin J, et al. Comparative mortality associated with ziprasidone and olanzapine in real-world use among 18,154 patients with schizophrenia: The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC). Am J Psychiatry. 2011;168(2):193–201.

    Google Scholar 

  4. Leucht S, Cipriani A, Spineli L, Mavridis D, Örey D, Richter F, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382(9896):951–62.

    Google Scholar 

  5. Caccia S, Pasina L, Nobili A. New atypical antipsychotics for schizophrenia: iloperidone. Drug Des Devel Ther. 2010;4:33–48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Janicak PG, Winans EA. Paliperidone ER: a review of the clinical trial data. Neuropsychiatr Dis Treat. 2007;3(6):869–97.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. US Food and Drug Adminstration. FDA Drug Safety Communication: revised recommendations for Celexa (citalopram bromide) related to a potential risk of abnormal heart rhythms with high doses. http://www.fda.gov/drugs/drugsafety/ucm297391.htm. Accessed Oct 14, 2016.

  8. Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100(10):609–15.

    Article  CAS  PubMed  Google Scholar 

  9. Zhou SH, Wong S, Rautaharju PM, Karnik N, Calhoun HP. Should the JT rather than the QT interval be used to detect prolongation of ventricular repolarization? An assessment in normal conduction and in ventricular conduction defects. J Electrocardiol. 1992;25(Suppl):131–6.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Internal Medicine & Psychiatry, Yale University School of Medicine, New Haven, CT, USA

    Aniyizhai Annamalai MD

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  1. Aniyizhai Annamalai MD
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Annamalai, A. (2017). QTc Prolongation. In: Medical Management of Psychotropic Side Effects. Springer, Cham. https://doi.org/10.1007/978-3-319-51026-2_8

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  • DOI: https://doi.org/10.1007/978-3-319-51026-2_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-51024-8

  • Online ISBN: 978-3-319-51026-2

  • eBook Packages: MedicineMedicine (R0)

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