Abstract
Pyogenic zoonotic streptococcal infections are neglected zoonoses which have increasingly been reported, especially in Asia, and can produce a wide variety of invasive diseases that mimic clinical entities produced by strictly human streptococci. The common human pathogen Streptococcus group B, now called Streptococcus agalactiae, may have originated from cows, and it is now recognized to cause invasive disease in fish as well. Sporadic cases of animal-derived streptococci had rarely been reported to cause human infections. These include Streptococcus canis from dogs and cats, Streptococcus equi zooepidemicus from horses and unpasteurized milk, Streptococcus iniae from fish, and more recently Streptococcus suis from pigs. S. suis is a major cause of disease in pigs worldwide with severe infections and high fatality in piglets from septicemia, meningitis, pneumonia, and septic arthritis and costs the global pig industry hundreds of millions of dollars. Moreover, S. suis has emerged as a serious major pathogen in humans throughout Southeast Asia and China in the past two decades. This pathogen has produced two deadly human outbreaks of septicemia and streptococcal toxic shock syndrome in China in 1998 and 2005. Furthermore, S. suis is the leading cause of adult bacterial meningitis in Vietnam, the second in Thailand and the third commonest in Hong Kong. There are 35 serotypes of S. suis recognized in animals, but human infections in Asia are caused predominantly by serotype 2. Animal strains of the bacteria are commonly multidrug resistant especially to tetracycline, clindamycin, macrolides, and the quinolones. Penicillin and beta-lactam agents are the drugs of choice. Numerous studies have been published on the virulence and pathogenic mechanisms of S. suis which are reviewed, and there are some common features shared with the virulent human Streptococcus pyogenes. Potential vaccine candidates for pig use are reviewed.
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References
Kohler W (2007) The present state of species within the genera Streptococcus and Enterococcus. Int J Med Microbiol 297:133–150
Lancefield RC (1933) A serological differentiation of human and other groups of hemolytic streptococci. J Exp Med 57:571–595
Gao XY, Zhi ZY, Li HW, Klenk HP, Li WJ (2014) Comparative genomics of the bacterial genus Streptococcus illuminates evolutionary implications of species groups. PLoS One 9:e101229
Sitkiewicz I, Hryniewicz W (2010) Pyogenic streptococci danger of re-emerging pathogens. Pol J Microbiol 59:219–226
Manning SD, Springman AC, Million AD et al (2010) Association of Group B Streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study. PLoS One 5:e8795
Liu G, Zhang W, Lu C (2013) Comparative genomics analysis of Streptococcus agalactiae reveals that isolates from cultured tilapia in China are closely related to the human strain A909. BMC Genomics 14:775
Bordes-Benitez A, Sanchez-Onoro M, Suarez-Bordon P et al (2006) Outbreak of Streptococcus equi subsp zooepidemicus infection on the island of Gran Canaria associated with the consumption of inadequately pasteurized cheese. Eur J Clin Microbiol Infect Dis 25:242–246
Vandamme P, Pot B, Falsen E, Kersters K, Devriese LA (1996) Taxonomic study of Lancefield streptococcal groups C, G, and L [Streptococcus dysgalactiae] and proposal of S. dysgalacvtiae subsp. equisimilis subsp. nov. Int J Syst Bacteriol 46:774–781
Bradley SF, Gordon JJ, Baumgartner DD, Marasco WA, Kauffman CA (1991) Group C streptococcal bacteremia: analysis of 88 cases. Rev Infect Dis 13:270–280
Brandt CM, Spellerberg B (2009) Human infections due to Streptococcus dysgalactiae subspecies equisimlis. Clin Infect Dis 49:766–772
Ikebe T, Oguro Y, Ogata K et al (2002) Surveillance of severe invasive group G streptococcal infections in Japan during 2002-2008. Jpn J Infect Dis 63:372–375
Devriese LA, Hommez J, Klipper-Balz R, Schleifer K-H (1986) Streptococcus canis sp. nov.: a species of group G Streptococci from animals. Int J Syst Bacteriol 36:422–425
Pinho MD, Matos SC, Pomba C et al (2013) Multilocus sequence analysis of Streptococcus canis confirms the zoonotic origin of human infections and reveals genetic exchange with Streptococcus dysgalactae subsp. equisimilis. J Clin Microbiol 51:1099–1109
DeWinter LM, Low DE, Prescott JF (1999) Virulence of Streptococcus canis from canine streptococcal toxic shock syndrome and necrotizing fasciitis. Vet Microbiol 70:95–110
Igwe EI, Shewmaker PL, Facklam RR, Farley MM, van Beneden C, Beall B (2003) Identification of superantigen genes specM, ssa and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans. FEMS Microbiol Lett 229:259–264
Fulde M, Rohde M, Hitznmann A, Preissner KT, Nitsche-Schmitz DP, Nerlich A, Chhatwal GS, Bergmann S (2011) SCM, a novel M-like protein from Streptococcus canis, binds [mini-] plasminogen with high affinity and facilitates bacterial transmigration. Biochem J 434:523–525
Egestein A, Frick IM, Olin AI, Bjorck L (2011) Binding of albumin promotes bacterial survival at the epithelial surface. J Biol Chem 286:2469–2476
Hare T, Frye RM (1938) Preliminary observation of an infection in dogs by beta-hemolytic streptococci. Vet Rec 50:213–218
Fulde M, Valentin-Weigand P (2013) Epidemiology and pathogenicity of zoonotic streptococci. Curr Top Microbiol Immunol 368:49–81
Lyskova P, Vydrazalova M, Mazurova J (2007) Identification and antimicrobial susceptibility of bacteria and yeasts isolated from healthy dogs and dogs with otitis externa. J Vet Med A Physiol Pathol Clin Med 54:559–563
TiKofsky LL, Zadoks RN (2005) Cross-infection between cats and cows: origin and control of Streptococcus canis mastitis in a dairy herd. J Dairy Sci 88:55–62
Richards VP, Zadoks RN, Pavinski Bitar PD et al (2012) Genome characterization and population genetic structure of the zoonotic pathogen, Streptococcus canis. BMC Microbiol 12:293
Lam MM, Claridge JE III, Young EJ, Mizuki S (2007) The other group G Streptococcus: increased detection of Streptococcus canis ulcer infection in dog owners. J Clin Microbiol 45:2327–2329
Bert F, Lambert-Zechovsky N (1997) Septicemia caused by Streptococcus canis in a human. J Clin Microbiol 35:777–779
Takeda N, Kikuchi K, Asano R et al (2001) Recurrent septicemia caused by Streptococcus canis after a dog bite. Scand J Infect Dis 33:927–928
Ohtaki H, Ohkusu K, Ohta H et al (2013) A case of sepsis caused by Streptococcus canis in a dog owner: a first case report of sepsis without dog bite in Japan. J Infect Chemother 19:1206–1209
Amsallem M, Lung B, Bnouleti C et al (2014) First reported human case of native mitral infective endocarditis caused by Streptococcus canis. Can J Cardiol 30:1462.e1–1462.e2
Bannister MF, Benson CF, Sweeney CR (1985) Rapid species identification of group C streptococci isolated from horses. J Clin Microbiol 21:524–526
Jensen A, Kilian M (2012) Delineation of Streptococcus dysgalactae, its subspecies, and its clinical and phylogenetic relationship to Streptococcus pyogenes. J Clin Microbiol 50:113–126
Timoney JF (2004) The pathogenic equine streptococci. Vet Res 35:397–4009
Holden MT, Heather Z, Pailott R et al (2009) Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens. PLoS Pathog 5:e1000346
Walker AS, Jolley KA (2007) Getting a grip on strangles: recent progress towards improved diagnostics and vaccines. Vet J 173:492–501
Parmar J, Winterbottom A, Cooke F, Lever AM, Gaunt M (2013) Endovascular aortic stent graft infection with Streptococcus equi: the first documented case. Vascular 21:14–16
Priestnall S, Erles K (2011) Streptococcus zooepidemicus: an emerging canine pathogen. Vet J 188:142–148
Feng Y, Zhang H, Ma Y, Gao GF (2010) Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent. Trends Microbiol 18:124–131
Soedarmanto I, Pasaribu FH, Wibawan IW, Lammler C (1996) Identification and molecular characterization of serological group C streptococci isolated from diseased pigs and monkeys in Indonesia. J Clin Microbiol 34:2201–2204
Bordes-Benitez A, Sanchez-Onoro M, Suarez-Maroto A et al (2006) Outbreak of Streptococcus equi subsp. zooepidemicus on the island of Gran Canaria associated with the consumption of inadequately pasteurized cheese. Eur J Clin Microbiol Infect Dis 25:242–246
Kuusi M, Lahti E, Virolainen A, Hatakka M et al (2006) An outbreak of Streptococcus equi subspecies zooepidemicus associated with consumption of fresh goat cheese. BMC Infect Dis 6:36
Balter S, Benin A, Pinto SW et al (2000) Epidemic nephritis in Nova Serrana, Brazil. Lancet 355:1776–1780
Yuen KY, Seto WH, Choi CH, Ng W, Ho SW, Chau PY (1990) Streptococcus zooepidemicus [Lancefield group C] septicemia in Hong Kong. J Infect 21:241–250
Guszynski K, Young A, Levine SJ et al (2015) Streptococcus equi subsp. zooepidemicus infections associated with guinea pigs. Emerg Infect Dis 21:156–158
Pelkonen S, Lindahl SB, Suomala P et al (2013) Transmission of Streptococcus equi subspecies zooepidemicus infection from horses to humans. Emerg Infect Dis 19:1041–1048
Alttreuther M, Lange C, Ho M, Hannula R (2013) Aortic graft infection and mycotic aneurism with Streptococcus equi zoooepidemicus: two cases with favorable outcome of antibiotic treatment. Vascular 21:6–9
Eyre DW, Kebnkre JS, Bowler IC, McBride SJ (2010) Streptococcus equi subspecies zooepidemicus meningitis a case report and review of the literature. Eur J Clin Microbiol Infect Dis 29:1459–1463
Reid HF, Bassett DC, Poon-King T, Zabriskie JB, Read SE (1985) Group G streptococci in healthy school-children and in patients with glomerulonephritis in Trinidad. J Hyg [London] 94:61–68
Haidan A, Talay SR, Rohde M et al (2000) Pharyngeal carriage of group C and G streptococci and acute rheumatic fever in an aboriginal population. Lancet 356:1167–1169
Preziuso S, Pinho MD, Attili AR et al (2014) PCR differentiation between Streptococcus dysgalactiae subsp. equisimilis strains isolated from humans and horses. Comp Immunol Microbiol Infect Dis 37:169–172
Agnew W, Barnes AC (2007) Streptococcus iniae: an aquatic pathogen of global veterinary significance and a challenging candidate for reliable vaccination. Vet Microbiol 122:1–15
Baums CG, Hermeyer K, Leimbach S et al (2013) Establishment of a model of Streptococcus iniae meningoencephalitis in Nile tilapia [Oreochromis niloticus]. J Comp Pathol 149:94–102
Keirstead ND, Brake JW, Griffin MJ, Halliday-Simmonds I, Thrall MA, Soto E (2014) Fatal septicemia caused by the zoonotic bacterium Streptococcus iniae during an outbreak in Caribbean reef fish. Vet Pathol 51:1035–1041
Weinstein MR, Litt M, KLertesz DA et al (1997) Invasive infection due to a fish pathogen, Streptococcus iniae. S. iniae study group. N Engl Med J Med 337:3016–3024
Sun JR, Yan JC, Yeh CY, Lee SY, Lu JJ (2007) Invasive infection with Streptococcus iniae in Taiwan. J Med Microbiol 56:1246–1249
Field HI, Buntain D, Done JT (1954) Studies on pig mortality. I. Streptococcal meningitis and arthritis. Vet Rec 66:453–455
Perch B, Kristjansen P, Skadhauge K (1968) Group R streptococci pathogenic for man: two cases of meningitis and one fatal case of sepsis. Acta Pathol Miocrobiol Scand 74:69–76
Arends JP, Zanen HC (1988) Meningitis caused by Streptococcus suis in humans. Rev Infect Dis 10:131–137
McLendon BF, Bron AJ, Mitchell CJ (1978) Streptococcus suis type II [group R] as a cause of endophthalmitis. Br J Ophthalmol 26:723–731
Wertheim HFL, Nghia HDT, Taylor W, Schultsz C (2009) Streptococcus suis: an emerging human pathogen. Emerg Infect Dis 48:617–625
Huong VTL, Ha N, Huy NT et al (2014) Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerg Infect Dis 20:1105–1114
Staats JJ, Feder I, Okwumabua O, Chengappa MM (1997) Streptococcus suis: past and present. Vet Res Commun 21:381–407
Amass SF, SanMiguel P, Clark LK (1997) Demonstration of vertical transmission of Streptococcus suis in swine by genomic fingerprinting. J Clin Microbiol 35:1595–1596
Sanchez del Rey V, Fernandez-Garayzabal JF, Briones V et al (2013) Genetic analysis of Streptococcus sui from wild rabbits. Vet Microbiol 165:483–486
Camporese A, Tizianel G, Bruschetta G, Cruchiatti B, Pomes A (2007) Human meningitis caused by Streptococcus suis: the first reported case from north-east Italy. Infez Med 15:111–114
Chatzopoulou M, Voulgaridou I, Papalas D, Vasilliou P, Tsiakalou M (2015) Third case of Streptococcus suis infection in Greece. Case Rep Infect Dis 2015:505834
Fongcom A, Prusksakorn S, Netsirisawan P, Pngprasert R, Onisibud P (2009) Streptococcus suis infection: a prospective study in northern Thailand. Southeast Asian J Trop Med Public Health 40:511–517
Donsakul K, Dejthevvporn C, Witoonpanich R (2003) Streptococcus suis infection: clinical features and diagnostic pitfalls. Southeast Asian J Trop Med Publ Health 34:154–158
Higgins R, Gottschalk M (1990) An update on Streptococcus suis identification. J Vet Diagn Investig 2:249–252
Segura M, Zheng H, de Greeff A et al (2014) Latest developments on Streptococcus suis: an emerging zoonotic pathogen: part 1. Future Microbiol 9:441–444 part 2: 587–591
Gottschalk M, Segura M, Xu J (2007) Streptococcus suis infections in humans: the Chinese experience and the situation in North America. Anim Health Res Rev 8:29–45
Lun ZR, Wang QP, Chen XG, Li AX, Zhu XQ (2007) Streptococcus suis: an emerging zoonotic pathogen. Lancet Infect Dis 7:201–209
Nga TV, Nghia HD, Tu le TP et al (2011) Real-time PCR for detection of Streptococcus suis serotype 2 in cerebrospinal fluid of human patients with meningitis. Diagn Microbiol Infect Dis 70:461–467
Ishida S, Tien le HT, Osawa R et al (2014) Development of an appropriate PCR system for the reclassification of Streptococcus suis. J Microbiol Methods 107:66–70
Liu Z, Zheng H, Gottschalk M et al (2013) Development of multiplex PCR assays for the identification of the 33 serotypes of Streptococcus suis. PLoS One 8:e72070
King SJ, Leigh JA, Heath PJ et al (2002) Development of a multilocus sequence typing scheme for the pig pathogen Streptococcus suis: identification of virulent clones and potential capsular serotype exchange. J Clin Microbiol 40:3671–3680
Fittipaldi N, Xu J, Lacouture S et al (2011) Lineage and virulence of Streptococcus suis serotype 2 isolates from North America. Emerg Infect Dis 17(12):2239–2244
Zhu W, Wu C, Sun X et al (2013) Characterization of Streptococcus suis serotype 2 isolates from China. Vet Microbiol 166:527–534
Kouki A, Haataja S, Loimaranta V, Pulianinen AT, Nilsson UJ, Finne J (2011) Identification of a novel streptococcal adhesion P [SadP] protein recognizing galactosyl-alpha 1-4-galactose-containing glycoconjugate: convergent evolution of bacterial pathogens to binding of the same host receptor. J Biol Chem 286:38854–38864
Fittipaldi N, Segura M, Grenier D, Gottschalk M (2012) Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis. Future Microbiol 7:259–279
Li W, Wan Y, Tao Z, Chen H, Zhou R (2013) A novel fibronectin-binding protein of Streptococcus suis serotype 2 contributes to epithelial cell invasion and in vivo dissemination. Vet Microbiol 162:186–194
Zhao YL, Zhou YH, Chen JQ et al (2015) Quantitative proteonomic analysis of sub-MIC erythromycin inhibiting biofilm formation of S. suis in vitro. J Proteomics 116:1–14
Dawei G, Liping W, Chengping L (2012) In vitro biofilm forming potential of Streptococcus suis isolated from human and swine in China. Braz J Microbiol 43:993–1004
Lecours MP, Segura M, Lachance C et al (2011) Characterization of porcine dendritic cell response to Streptococcus suis. Vet Res 42:72
Zhang A, Mu X, Chen B et al (2010) Identification and characterization of IgA1 protease from Streptococcus suis. Vet Microbiol 140:171–175
Houde M, Gottschalk M, Gagnon F, Van Calsteren MR, Segura M (2012) Streptococcus suis capsular polysaccharide inhibits phagocytosis through destabilization of lipid microdomain and prevents lactosylceramide-dependent recognition. Infect Immun 80:506–517
Lecours MP, Gottschalk M, Houde M, Lemire P, Fittipaldi N, Segura M (2011) Critical role for Streptococcus suis cell wall modifications and suilysin in resistance to complement-dependent killing by dendritic cells. J Infect Dis 204:919–929
He Z, Pian Y, Ren Z et al (2014) Increased production of suilysin contributes to invasive infection of the Streptococcus suis strain 05ZYH33. Mol Med Rep 10:2819–2826
Ferrando ML, Schultsz C (2016) A hypothetical model of host-pathogen interaction of Streptococcus suis in the gastrointestinal tract. Gut Microbes 7:154–162
Chen C, Tang J, Dong W et al (2007) A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates. PLoS One 2:e315
Zheng H, Ye C, Segura M, Gottschalk M, Xu J (2008) Mitogenic effect contributes to increased virulence of Streptococcus suis sequence type 7 to cause streptococcal toxic shocke-like syndrome. Clin Exp Immunol 153:385–391
Ye C, Zheng H, Zheng J et al (2009) Clinical, experimental, and genomic differences between intermediate pathogenic, highly pathogenic, and epidemic Streptococcus suis. J Infect Dis 199:97–107
Tenenbaum T, Essmann F, Adam R et al (2006) Cell death, caspase activation, and HMGB1 release of porcine choroid plexus epithelial cells during Streptococcus suis infection in vitro. Brain Res 1100:1–12
Zheng P, Zhao YX, Zhang AD, Kang C, Chen HC, Jin ML (2009) Pathological analysis of the brain from Streptococcus suis type 2 experimentally infected pigs. Vet Pathol 46:531–535
Dominguez-Punaro Mde L, Segura M, Conteras I et al (2010) In vitro characterization of the microglial inflammatory response to Streptococcus suis, an important emerging zoonotic agent of meningitis. Infect Immun 78:5074–5085
Auger JP, Christodoulides M, Segura M, Xu J, Gottschalk M (2015) Interactions of Streptococcus suis serotype 2 with human meningeal cells and astrocytes. BMC Res Notes 8:607
Sun Y, Li N, Zhang J et al (2016) Enolase of Streptococcus suis serotype 2 enhances blood-brain barrier permeability by inducing IL-8 release. Inflammation 39:718–726
Wewer C, Seibert A, Wolburg H et al (2011) Transcellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis. J Neuroinflammation 8:51
Eisenberg T, Hudemann C, Hossain HM et al (2015) Characterization of five zoonotic Streptococcus suis strains from Germany, including one isolate from a recent fatal case of streptococcal toxic shock-like syndrome in a hunter. J Clin Microbiol 53:3012–3015
Smith TC, Capuano AW, Boese B, Myers KP, Gray GC (2008) Exposure to Streptococcus suis among US swine workers. Emerg Infect Dis 14:1925–1927
Goyette-Desjardins G, Auger J-P, Xu J, Segura M, Gottschalk M (2014) Streptococcus suis, an important pig pathogen and emerging zoonotic agent an update on the worldwide distribution based on serotyping and sequencing typing. Emerg Microbes Infect 3:e45. doi:10.1038/emi.2014.45
Nghia HD, le TP T, Wolbers M et al (2011) Risk factors of Streptococcus suis infection in Vietnam. A case-control study. PLoS One 6:e17604
Ip M, Fung KS, Chi F et al (2007) Streptococcus suis in Hong Kong. Diagn Microbiol Infect Dis 57:15–20
Ngo TH, Tran TB, Tran TT et al (2011) Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam. PLoS One 6:e17943
Soares TC, Gottschalk M, Lacourture S et al (2015) Streptococcus suis in employees and the environment of swine slaughterhouse in Sao Paolo, Brazil: Occurrence, risk factors, serotype distribution, and antimicrobial susceptibility. Can J Vet Res 79:279–284
Hatrongjit R, Kerdsin A, Gottschalk M et al (2015) First human case report of sepsis due to infection with Streptococcus suis serotype 31 in Thailand. BMC Infect Dis 15:392
Takeuchi D, Kerdsin A, Pienpringam A et al (2012) Population-based study of Streptococcus suis infection in humans in Phayao Province in northern Thailand. PLoS One 7:e31265
Nakayama T, Takeuchi D, Matsumura T, Akeda Y, Fujinaga Y, Oishi K (2013) Alcohol consumption promotes the intestinal translocation of Streptococcus suis infection. Microb Pathog 65:14–20
Yu H, Jing H, Chen Z et al (2006) Human Streptococcus suis outbreak, Sichuan, China. Emerg Infect Dis 12:912–914
Mai NT, Hoa NT, Nga TV et al (2008) Streptococcus suis meningitis in adults in Vietnam. Clin Infect Dis 46:659–667
Kerdsin A, Dejsirilert S, Puangpatra P et al (2011) Genetic profile of Streptococcus suis serotype 2 and clinical features of clinical infection in humans, Thailand. Emerg Infect Dis 17:835–842
van Samkar A, Brouwer MC, Schultsz C, van der Ende A, van de Beek D (2015) Streptococcus suis meningitis: a systematic review and meta-analysis. PLoS Negl Trop Dis 9:e0004191
Heckenberg SG, de Gans J, Brouwer MC et al (2008) Clinical features, outcome, and meningococcal genotype in 258 adults with meningococcal meningitis: a prospective cohort study. Medicine (Baltimore) 87:185–192
Wangsomboonsiri W, Luksananun T, Saksornchai S, Ketwong K, Sungkanuparph S (2008) Streptococcus suis infection and risk factors for mortality. J Infect 57:392–396
Dominguez-Punaro MC, Koedel U, Hoegen T, Demel C, Klein M, Gottschalk M (2012) Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice. Eur J Clin Infect Dis 1:2391–2400
Tsai HY, Liao CH, Liu CY, Huang YT, Teng LJ, Hsueh PR (2012) Streptococcus suis infection in Taiwan, 2000-2011. Diagn Microbiol Infect Dis 74:75–77
Chen L, Song Y, Wei Z, He H, Zhang A, Jin M (2013) Antimicrobial susceptibility, tetracycline and erythromycin resistance genes, and multilocus sequence typing of Streptococcus suis isolates from diseased pigs in China. J Vet Med Sci 75:583–587
Zhang C, Zhang Z, Song L et al (2015) Antimicrobial resistance profile and genotype of Streptococcus suis capsular type 2 isolated from clinical carrier sows and diseased pigs in China. Biomed Res Int 2015:284303
Meng X, Shi Y, Ji W et al (2011) Application of a bacteriophage lysine to disrupt biofilms formed by the animal pathogen Streptococcus suis. Appl Environ Microbiol 77:8272–8279
Lebel G, Piche F, Frenette M, Gottschalk M, Grenier D (2013) Antimicrobial activity of nisin against the swine pathogen Streptococcus suis and its synergisyic interaction with antibiotics. Peptides 50:19–23
Segura M (2015) Streptococcus suis vaccines: candidate antigens and progress. Expert Rev Vaccines 14:1587–1608
Baums CG, Bruggemann C, Kock C et al (2010) Immunogenicity of an autogenous Streptococcus suis bacterin in preparturient sows and their piglets after weaning. Clin Vaccine Immunol 17:1589–1597
Kock C, Beineke A, Seirz M et al (2009) Intranasal immunization with a live Streptococcus suis isogenic of mutant elicited suilysin neutralization titers but failed to induce opsonizing antibodies and protection. Vet Immunol Immunopathol 132:135–145
Yao X, Li M, Wang J et al (2015) Isolation and characterization of a native avirulent strain of Streptococcus suis serotype 2: a perspective for vaccine development. Sci Rep 5:9835
Li Y, Martinez G, Gottschalk M et al (2006) Identification of a surface protein of Streptococcus suis and evaluation of its immunogenic and protective capacity in pigs. Infect Immun 74:305–312
Zhou Y, Wang Y, Deng L et al (2015) Evaluation of the protective efficacy of four novel identified membrane associated proteins of Streptococcus suis serotype 2. Vaccine 33:2254–2260
Charland N, Jacques M, Lacouture S et al (1997) Characterization and protective activity of a monoclonal antibody against a capsular epitope shared by Streptococcus suis serotypes 1, 2 and ½. Microbiology 143:3607–3614
Calzas C, Lemiere P, Auray G, Gerdts V, Gottschalk M, Segura M (2015) Antibody response specific to the capsular polysaccharide is impaired in Streptococcus suis serotype 2-infected animals. Infect Immun 83:441–453
Roma-Rodrigues C, Alves-Barroco C, Raposo LR et al (2016) Infection of human kerationocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder. Microbes Infect 18:290–293
Dumke J, Hinse D, Vollmer T, Knabbe C, Dreier J (2014) Development and application of a multilocus sequence typing scheme for Streptococcus gallolyticus subsp. gallolyticus. J Clin Microbiol 52:2472–2478
Goyette-Desjardins G, Clazas C, Shiao TC et al (2016) Protection against Streptococcus suis serotype 2 infection using capsular polysaccharide glycoconjugate vaccine. Infect Immun 84:2059–2075
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Fong, I.W. (2017). Zoonotic Streptococci: A Focus on Streptococcus suis . In: Emerging Zoonoses. Emerging Infectious Diseases of the 21st Century. Springer, Cham. https://doi.org/10.1007/978-3-319-50890-0_10
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