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Case-Based Lessons in the Management of Complex Hepato-Pancreato-Biliary Surgery pp 413–425Cite as

Total Pancreatectomy with Islet Autotransplantation

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Abstract

In selected patients with debilitating pain from chronic pancreatitis, total pancreatectomy with islet autotransplantation can be beneficial in relieving pain and improving quality of life. Patient selection is key for this radical procedure. Patients with diffuse small duct chronic pancreatitis, those with genetic pancreatitis, and patients who have failed lesser interventions may be candidates. Intraoperative techniques are aimed at minimizing warm ischemic time. Perioperative care is focused on optimizing islet survival and engraftment, including careful blood glucose management and anticoagulation. Recognition of potential procedure-specific complications is essential to ensure good outcomes. Long-term support is ideal for successful management of pancreatic exocrine insufficiency, for good islet function, and for best achievement of improved quality of life.

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References

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Authors and Affiliations

  1. Department of Surgery, Indiana University, 545 Barnhill Drive, EH 545, Indianapolis, IN, 46202, USA

    William P. Lancaster

  2. Medical University of South Carolina, 114 Doughty Street, Suite 249, Charleston, SC, 29425, USA

    Katherine A. Morgan

Authors
  1. William P. Lancaster
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  2. Katherine A. Morgan
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Corresponding author

Correspondence to Katherine A. Morgan .

Editor information

Editors and Affiliations

  1. The Ohio State Wexner Medical Center , The Ohio State University School of Medicine , Columbus, Ohio, USA

    Timothy M. Pawlik

  2. Division of General Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA

    Sharon Weber

  3. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    T. Clark Gamblin

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Lancaster, W.P., Morgan, K.A. (2017). Total Pancreatectomy with Islet Autotransplantation. In: Pawlik, T., Weber, S., Gamblin, T. (eds) Case-Based Lessons in the Management of Complex Hepato-Pancreato-Biliary Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-50868-9_32

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  • DOI: https://doi.org/10.1007/978-3-319-50868-9_32

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-50867-2

  • Online ISBN: 978-3-319-50868-9

  • eBook Packages: MedicineMedicine (R0)

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