Classification of FDG-PET Brain Data by Generalized Matrix Relevance LVQ

  • M. BiehlEmail author
  • D. Mudali
  • K. L. Leenders
  • J. B. T. M. Roerdink
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10087)


We apply Generalized Matrix Learning Vector Quantization (GMLVQ) to the classification of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) brain data. The aim is to achieve accurate detection and discrimination of neurodegenerative syndromes such as Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy. Image data are pre-processed and analysed in terms of low-dimensional representations obtained by Principal Component Analysis in the Scaled Subprofile Model approach. The performance of the GMLVQ classifiers is evaluated in a Leave-One-Out framework. Comparison with earlier results shows that GMLVQ and Support Vector Machine with linear kernel achieve comparable performance while both outperform a C4-5 Decision Tree classifier.


Support Vector Machine Multiple System Atrophy Receiver Operator Characteristic Progressive Supranuclear Palsy Progressive Supranuclear Palsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • M. Biehl
    • 1
    Email author
  • D. Mudali
    • 1
  • K. L. Leenders
    • 2
  • J. B. T. M. Roerdink
    • 1
    • 3
  1. 1.Johann Bernoulli Institute for Mathematics and Computer ScienceUniversity of GroningenGroningenThe Netherlands
  2. 2.Department of NeurologyUniversity Medical Center GroningenGroningenThe Netherlands
  3. 3.Neuroimaging Center, University Medical Center GroningenGroningenThe Netherlands

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