Abstract
D. where it is possible to answer two (or more) questions for the “price” of one (two interventions are of interest and the application of one does not interfere with the application of the other; i.e. different endpoints are appropriate for the evaluation, intervention(s) are likely to be ineffective a.s.o.); comparisons can be either between subjects or within subjects; example: study-design with four parallel groups, each receiving one specific treatment (A, B, A + B, placebo); this d. gives four estimates for four groups, i.e. two estimates for each drug effect; a standard design would consist of three groups (A, B, placebo) giving an estimate of the effect of A, as well as of B; suitable for “economising” patient numbers and for studying treatment interactions; as this design implicates multiple comparisons it is necessary to perform corrections (Bonferroni) for the statistical testing.
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Nahler, G. (2017). F. In: Dictionary of Pharmaceutical Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-50669-2_6
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DOI: https://doi.org/10.1007/978-3-319-50669-2_6
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